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Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

Vision Transformers are at the heart of the current surge of interest in foundation models for histopathology. They process images by breaking them into smaller patches following a regular grid, regardless of their content. Yet, not all…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Clément Grisi , Geert Litjens , Jeroen van der Laak

Histopathology Whole Slide Image (WSI) analysis serves as the gold standard for clinical cancer diagnosis in the daily routines of doctors. To develop computer-aided diagnosis model for WSIs, previous methods typically employ Multi-Instance…

Computer Vision and Pattern Recognition · Computer Science 2024-10-21 Honglin Li , Yunlong Zhang , Pingyi Chen , Zhongyi Shui , Chenglu Zhu , Lin Yang

Whole Slide Image (WSI) analysis is a powerful method to facilitate the diagnosis of cancer in tissue samples. Automating this diagnosis poses various issues, most notably caused by the immense image resolution and limited annotations. WSIs…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Ahmet Gokberk Gul , Oezdemir Cetin , Christoph Reich , Tim Prangemeier , Nadine Flinner , Heinz Koeppl

Accurate segmentation of Optical Coherence Tomography (OCT) images is crucial for diagnosing and monitoring retinal diseases. However, the labor-intensive nature of pixel-level annotation limits the scalability of supervised learning for…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Jiaqi Yang , Nitish Mehta , Xiaoling Hu , Chao Chen , Chia-Ling Tsai

Eye gaze that reveals human observational patterns has increasingly been incorporated into solutions for vision tasks. Despite recent explorations on leveraging gaze to aid deep networks, few studies exploit gaze as an efficient annotation…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Yuan Zhong , Chenhui Tang , Yumeng Yang , Ruoxi Qi , Kang Zhou , Yuqi Gong , Pheng Ann Heng , Janet H. Hsiao , Qi Dou

In this paper, we develop a new weakly-supervised learning algorithm to learn to segment cancerous regions in histopathology images. Our work is under a multiple instance learning framework (MIL) with a new formulation, deep weak…

Computer Vision and Pattern Recognition · Computer Science 2017-08-30 Zhipeng Jia , Xingyi Huang , Eric I-Chao Chang , Yan Xu

In this paper, we propose a novel interpretation method tailored to histological Whole Slide Image (WSI) processing. A Deep Neural Network (DNN), inspired by Bag-of-Features models is equipped with a Multiple Instance Learning (MIL) branch…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Magdalini Paschali , Muhammad Ferjad Naeem , Walter Simson , Katja Steiger , Martin Mollenhauer , Nassir Navab

Weakly-supervised learning (WSL) has recently triggered substantial interest as it mitigates the lack of pixel-wise annotations. Given global image labels, WSL methods yield pixel-level predictions (segmentations), which enable to interpret…

Computer Vision and Pattern Recognition · Computer Science 2021-10-12 Soufiane Belharbi , Jérôme Rony , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Explainable AI (XAI) in medical histopathology is essential for enhancing the interpretability and clinical trustworthiness of deep learning models in cancer diagnosis. However, the black-box nature of these models often limits their…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 Raktim Kumar Mondol , Ewan K. A. Millar , Peter H. Graham , Lois Browne , Arcot Sowmya , Erik Meijering

The Segment Anything Model (SAM) marks a significant advancement in segmentation models, offering robust zero-shot abilities and dynamic prompting. However, existing medical SAMs are not suitable for the multi-scale nature of whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hong Liu , Haosen Yang , Paul J. van Diest , Josien P. W. Pluim , Mitko Veta

Weakly supervised semantic segmentation (WSSS) in medical imaging struggles with effectively using sparse annotations. One promising direction for WSSS leverages gaze annotations, captured via eye trackers that record regions of interest…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Zhisong Wang , Yiwen Ye , Ziyang Chen , Yong Xia

Image analysis and machine learning algorithms operating on multi-gigapixel whole-slide images (WSIs) often process a large number of tiles (sub-images) and require aggregating predictions from the tiles in order to predict WSI-level…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Mohsin Bilal , Robert Jewsbury , Ruoyu Wang , Hammam M. AlGhamdi , Amina Asif , Mark Eastwood , Nasir Rajpoot

Weakly-Supervised Concealed Object Segmentation (WSCOS) aims to segment objects well blended with surrounding environments using sparsely-annotated data for model training. It remains a challenging task since (1) it is hard to distinguish…

Computer Vision and Pattern Recognition · Computer Science 2023-05-19 Chunming He , Kai Li , Yachao Zhang , Guoxia Xu , Longxiang Tang , Yulun Zhang , Zhenhua Guo , Xiu Li

Classification of gigapixel Whole Slide Images (WSIs) is an important prediction task in the emerging area of computational pathology. There has been a surge of research in deep learning models for WSI classification with clinical…

Computer Vision and Pattern Recognition · Computer Science 2023-05-04 Sajid Javed , Arif Mahmood , Talha Qaiser , Naoufel Werghi , Nasir Rajpoot

As 3D perception problems grow in popularity and the need for large-scale labeled datasets for LiDAR semantic segmentation increase, new methods arise that aim to reduce the necessity for dense annotations by employing weakly-supervised…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Ozan Unal , Dengxin Dai , Lukas Hoyer , Yigit Baran Can , Luc Van Gool

Weakly supervised instance segmentation (WSIS) using only image-level labels is a challenging task due to the difficulty of aligning coarse annotations with the finer task. However, with the advancement of deep neural networks (DNNs), WSIS…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Zecheng Li , Zening Zeng , Yuqi Liang , Jin-Gang Yu

One of the main obstacles of adopting digital pathology is the challenge of efficient processing of hyperdimensional digitized biopsy samples, called whole slide images (WSIs). Exploiting deep learning and introducing compact WSI…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Azam Asilian Bidgoli , Shahryar Rahnamayan , Taher Dehkharghanian , Abtin Riasatian , H. R. Tizhoosh

Weak gravitational lensing observations are a key science driver for the NASA Wide Field Infrared Survey Telescope (WFIRST). To validate the performance of the WFIRST infrared detectors, we have performed a laboratory emulation of weak…

Instrumentation and Methods for Astrophysics · Physics 2015-06-16 Suresh Seshadri , Charles Shapiro , Timothy Goodsall , Jason Fucik , Christopher M. Hirata , Jason Rhodes , Barnaby Rowe , Roger Smith

Sparse vision transformers have gained popularity as efficient encoders for medical volumetric segmentation, with Swin emerging as a prominent choice. Swin uses local attention to reduce complexity and yields excellent performance for many…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 David Hagerman , Roman Naeem , Jakob Lindqvist , Carl Lindström , Fredrik Kahl , Lennart Svensson
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