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Deep learning models have gained increasing adoption in medical image analysis. However, these models often produce overconfident predictions, which can compromise clinical accuracy and reliability. Bridging the gap between high-performance…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Jutika Borah , Hidam Kumarjit Singh

At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together…

Machine Learning · Computer Science 2020-05-07 Afra Nawar , Farhan Rahman , Narayanan Krishnamurthi , Anirudh Som , Pavan Turaga

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by atypical brain maturation. However, the adaptation of transfer learning paradigms in machine learning for ASD research remains notably limited. In this study,…

Machine Learning · Computer Science 2025-09-16 Kush Gupta , Amir Aly , Emmanuel Ifeachor , Rohit Shankar

In this paper, we propose a new approach to pathological speech synthesis. Instead of using healthy speech as a source, we customise an existing pathological speech sample to a new speaker's voice characteristics. This approach alleviates…

Depression detection research has increased over the last few decades, one major bottleneck of which is the limited data availability and representation learning. Recently, self-supervised learning has seen success in pretraining text…

Human-Computer Interaction · Computer Science 2021-10-29 Pingyue Zhang , Mengyue Wu , Heinrich Dinkel , Kai Yu

Interpretability allows the domain-expert to directly evaluate the model's relevance and reliability, a practice that offers assurance and builds trust. In the healthcare setting, interpretable models should implicate relevant biological…

Machine Learning · Computer Science 2020-06-18 Thomas P. Quinn , Dang Nguyen , Santu Rana , Sunil Gupta , Svetha Venkatesh

While vector-based language representations from pretrained language models have set a new standard for many NLP tasks, there is not yet a complete accounting of their inner workings. In particular, it is not entirely clear what aspects of…

Computation and Language · Computer Science 2021-04-16 Matteo Alleman , Jonathan Mamou , Miguel A Del Rio , Hanlin Tang , Yoon Kim , SueYeon Chung

This paper is motivated by the automation of neuropsychological tests involving discourse analysis in the retellings of narratives by patients with potential cognitive impairment. In this scenario the task of sentence boundary detection in…

Computation and Language · Computer Science 2017-08-17 Marcos V. Treviso , Christopher D. Shulby , Sandra M. Aluisio

The Hawkes process (HP) is commonly used to model event sequences with self-reinforcing dynamics, including electronic health records (EHRs). Traditional HPs capture self-reinforcement via parametric impact functions that can be inspected…

Machine Learning · Statistics 2025-10-23 Yuankang Zhao , Matthew Engelhard

Pathological images play an essential role in cancer prognosis, while survival analysis, which integrates computational techniques, can predict critical clinical events such as patient mortality or disease recurrence from whole-slide images…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Guo Tang , Songhan Jiang , Jinpeng Lu , Linghan Cai , Yongbing Zhang

We introduce Matched Machine Learning, a framework that combines the flexibility of machine learning black boxes with the interpretability of matching, a longstanding tool in observational causal inference. Interpretability is paramount in…

Methodology · Statistics 2023-04-05 Marco Morucci , Cynthia Rudin , Alexander Volfovsky

Computer aided diagnosis systems can provide non-invasive, low-cost tools to support clinicians. These systems have the potential to assist the diagnosis and monitoring of neurodegenerative disorders, in particular Parkinson's disease (PD).…

Computer Vision and Pattern Recognition · Computer Science 2024-05-24 Moises Diaz , Miguel Angel Ferrer , Donato Impedovo , Giuseppe Pirlo , Gennaro Vessio

Speaker individuality information is among the most critical elements within speech signals. By thoroughly and accurately modeling this information, it can be utilized in various intelligent speech applications, such as speaker recognition,…

Audio and Speech Processing · Electrical Eng. & Systems 2024-11-05 Shuai Wang , Zhengyang Chen , Kong Aik Lee , Yanmin Qian , Haizhou Li

Electroencephalography has been established as an effective method for detecting Parkinson's disease, typically diagnosed early.Current Parkinson's disease detection methods have shown significant success within individual datasets,…

Machine Learning · Computer Science 2025-08-21 Qian Zhang , Ruilin Zhang , Biaokai Zhu , Xun Han , Jun Xiao , Yifan Liu , Zhe Wang

Speech enhancement in hearing aids remains a difficult task in nonstationary acoustic environments, mainly because current signal processing algorithms rely on fixed, manually tuned parameters that cannot adapt in situ to different users or…

Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…

Machine Learning · Computer Science 2021-08-03 Amish Mittal , Sourav Sahoo , Arnhav Datar , Juned Kadiwala , Hrithwik Shalu , Jimson Mathew

This paper deals with a complex acoustic analysis of phonation in patients with Parkinson's disease (PD) with a special focus on estimation of disease progress that is described by 7 different clinical scales ,e. g. Unified Parkinson's…

Despite Large Language Models' remarkable capabilities, understanding their internal representations remains challenging. Mechanistic interpretability tools such as sparse autoencoders (SAEs) were developed to extract interpretable features…

Machine Learning · Computer Science 2026-01-06 Xiangchen Song , Jiaqi Sun , Zijian Li , Yujia Zheng , Kun Zhang

In recent years, there are many research cases for the diagnosis of Parkinson's disease (PD) with the brain magnetic resonance imaging (MRI) by utilizing the traditional unsupervised machine learning methods and the supervised deep learning…

Image and Video Processing · Electrical Eng. & Systems 2020-03-11 Xiaobo Zhang , Donghai Zhai , Yan Yang , Yiling Zhang , Chunlin Wang

Nearly one in five adolescents currently live with a diagnosed mental or behavioral health condition, such as anxiety, depression, or conduct disorder, underscoring the urgency of developing accurate and interpretable diagnostic tools.…

Machine Learning · Computer Science 2025-10-07 Song Wang , Zhenyu Lei , Zhen Tan , Jundong Li , Javier Rasero , Aiying Zhang , Chirag Agarwal