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Objectives: With accurate estimates of expected safety results, clinical trials could be better designed and monitored. We evaluated methods for predicting serious adverse event (SAE) results in clinical trials using information only from…

Computation and Language · Computer Science 2025-08-12 Qixuan Hu , Xumou Zhang , Jinman Kim , Florence Bourgeois , Adam G. Dunn

Patient status, angiographic and procedural characteristics encode crucial signals for predicting long-term outcomes after percutaneous coronary intervention (PCI). The aim of the study was to develop a predictive model for assessing the…

Machine Learning · Computer Science 2025-12-30 Daniil Burakov , Ivan Petrov , Dmitrii Khelimskii , Ivan Bessonov , Mikhail Lazarev

In oncology, recurrence after treatment is one of the major challenges, related to patients' survival and quality of life. Conventionally, prediction of cancer relapse has always relied on clinical observation with statistical model…

Machine Learning · Computer Science 2025-02-25 Muhammad Umer Qayyum , Muhammad Fahad , Nasrullah Abbasi

Clinical trials face mounting challenges: fragmented patient populations, slow enrollment, and unsustainable costs, particularly for late phase trials in oncology and rare diseases. While external control arms built from real-world data…

Machine Learning · Computer Science 2025-11-21 Perrine Chassat , Van Tuan Nguyen , Lucas Ducrot , Emilie Lanoy , Agathe Guilloux

Estimating treatment effects from observational data is challenging due to two main reasons: (a) hidden confounding, and (b) covariate mismatch (control and treatment groups not having identical distributions). Long lines of works exist…

Machine Learning · Computer Science 2025-04-30 Praharsh Nanavati , Ranjitha Prasad , Karthikeyan Shanmugam

Machine learning is used in medicine to support physicians in examination, diagnosis, and predicting outcomes. One of the most dynamic area is the usage of patient generated health data from intensive care units. The goal of this paper is…

Stroke remains one of the most critical global health challenges, ranking as the second leading cause of death and the third leading cause of disability worldwide. This study explores the effectiveness of machine learning algorithms in…

Machine Learning · Computer Science 2025-05-16 Anastasija Tashkova , Stefan Eftimov , Bojan Ristov , Slobodan Kalajdziski

The generalizability of machine learning (ML) models for wearable monitoring in stroke rehabilitation is often constrained by the limited scale and heterogeneity of available data. Data augmentation addresses this challenge by adding…

Machine Learning · Computer Science 2024-11-01 Aaron J. Hadley , Christopher L. Pulliam

The goal of this work is to identify the best optimizers for deep learning in the context of cardiac image segmentation and to provide guidance on how to design segmentation networks with effective optimization strategies. Adaptive learning…

Image and Video Processing · Electrical Eng. & Systems 2023-02-07 Aliasghar Mortazi , Vedat Cicek , Elif Keles , Ulas Bagci

Acute kidney injury (AKI) is a common and serious complication after a surgery which is associated with morbidity and mortality. The majority of existing perioperative AKI risk score prediction models are limited in their generalizability…

Computers and Society · Computer Science 2019-06-19 Lasith Adhikari , Tezcan Ozrazgat-Baslanti , Paul Thottakkara , Ashkan Ebadi , Amir Motaei , Parisa Rashidi , Xiaolin Li , Azra Bihorac

Purpose: Chest X-rays are essential for diagnosing pulmonary conditions, but limited access in resource-constrained settings can delay timely diagnosis. Electrocardiograms (ECGs), in contrast, are widely available, non-invasive, and often…

Signal Processing · Electrical Eng. & Systems 2025-09-23 Julia Matejas , Olaf Żurawski , Nils Strodthoff , Juan Miguel Lopez Alcaraz

Worldwide, many millions of people die suddenly and unexpectedly each year, either with or without a prior history of cardiovascular disease. Such events are sparse (once in a lifetime), many victims will not have had prior investigations…

Machine Learning · Computer Science 2023-09-06 Yola Jones , Fani Deligianni , Jeff Dalton , Pierpaolo Pellicori , John G F Cleland

Stem cell therapy is a promising approach to treat heart insufficiency and benefits from automated myocardial injection which requires highly precise motion of a robotic manipulator that is equipped with a syringe. This work investigates…

Robotics · Computer Science 2024-09-11 Michael Meindl , Raphael Mönkemöller , Thomas Seel

Recent randomised clinical trials have shown that patients with ischaemic stroke {due to occlusion of a large intracranial blood vessel} benefit from endovascular thrombectomy. However, predicting outcome of treatment in an individual…

Image and Video Processing · Electrical Eng. & Systems 2024-12-09 Zeynel A. Samak , Philip Clatworthy , Majid Mirmehdi

Background: Aspiration, the inhalation of foreign material into the lungs, significantly impacts surgical patient morbidity and mortality. This study develops a machine learning (ML) model to predict postoperative aspiration, enabling…

Machine Learning · Computer Science 2025-10-30 Supriya Nagesh , Karina Covarrubias , Robert El-Kareh , Shiva Prasad Kasiviswanathan , Nina Mishra

In the field of heart disease classification, two primary obstacles arise. Firstly, existing Electrocardiogram (ECG) datasets consistently demonstrate imbalances and biases across various modalities. Secondly, these time-series data consist…

Machine Learning · Computer Science 2024-07-31 Thao Hoang , Linh Nguyen , Khoi Do , Duong Nguyen , Viet Dung Nguyen

Diagnosis of adverse neonatal outcomes is crucial for preterm survival since it enables doctors to provide timely treatment. Machine learning (ML) algorithms have been demonstrated to be effective in predicting adverse neonatal outcomes.…

This study presents a machine learning-based framework for heart disease prediction using the heart-disease dataset, comprising 303 samples with 14 features. The methodology involves data preprocessing, model training, and evaluation using…

Machine Learning · Computer Science 2025-05-16 Ali Azimi Lamir , Shiva Razzagzadeh , Zeynab Rezaei

When technical requirements are high, and patient outcomes are critical, opportunities for monitoring and improving surgical skills via objective motion analysis feedback may be particularly beneficial. This narrative review synthesises…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Merryn D. Constable , Hubert P. H. Shum , Stephen Clark

Traffic accidents pose a severe global public health issue, leading to 1.19 million fatalities annually, with the greatest impact on individuals aged 5 to 29 years old. This paper addresses the critical need for advanced predictive methods…

Machine Learning · Computer Science 2024-06-21 Noushin Behboudi , Sobhan Moosavi , Rajiv Ramnath