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Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

Computation and Language · Computer Science 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

Large Language Models (LLMs) are increasingly used in agentic systems, where their interactions with diverse tools and environments create complex, multi-stage safety challenges. However, existing benchmarks mostly rely on static,…

Cryptography and Security · Computer Science 2026-02-03 Liming Lu , Xiang Gu , Junyu Huang , Jiawei Du , Xu Zheng , Yunhuai Liu , Yongbin Zhou , Shuchao Pang

As opposed to evaluating computation and logic-based reasoning, current benchmarks for evaluating large language models (LLMs) in medicine are primarily focused on question-answering involving domain knowledge and descriptive reasoning.…

Multi-agent systems (MAS) powered by large language models (LLMs) hold significant promise for solving complex decision-making tasks. However, the core process of collaborative decision-making (CDM) within these systems remains…

Artificial Intelligence · Computer Science 2025-08-19 Xuyang Zhao , Shiwan Zhao , Hualong Yu , Liting Zhang , Qicheng Li

Large Language Models (LLMs) have demonstrated impressive performance in executing complex reasoning tasks. Chain-of-thought effectively enhances reasoning capabilities by unlocking the potential of large models, while multi-agent systems…

Computation and Language · Computer Science 2026-02-11 Jiaxing Zhao , Hongbin Xie , Yuzhen Lei , Xuan Song , Zhuoran Shi , Lianxin Li , Shuangxue Liu , Linguo Xie , Haoran Zhang

The large-scale deployment of personalized healthcare agents demands memory mechanisms that are exceptionally precise, safe, and capable of long-term clinical tracking. However, existing benchmarks primarily focus on daily open-domain…

Artificial Intelligence · Computer Science 2026-05-13 Yihao Wang , Haoran Xu , Renjie Gu , Yixuan Ye , Xinyi Chen , Xinyu Mu , Yuan Gao , Chunxiao Guo , Peng Wei , Jinjie Gu , Huan Li , Ke Chen , Lidan Shou

As LLM-based agents are increasingly deployed in real-life scenarios, existing benchmarks fail to capture their inherent complexity of handling extensive information, leveraging diverse resources, and managing dynamic user interactions. To…

Computation and Language · Computer Science 2025-10-20 Wei He , Yueqing Sun , Hongyan Hao , Xueyuan Hao , Zhikang Xia , Qi Gu , Chengcheng Han , Dengchang Zhao , Hui Su , Kefeng Zhang , Man Gao , Xi Su , Xiaodong Cai , Xunliang Cai , Yu Yang , Yunke Zhao

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

Clinical robustness is critical to the safe deployment of medical Large Language Models (LLMs), but key questions remain about how LLMs and humans may differ in response to the real-world variability typified by clinical settings. To…

Artificial Intelligence · Computer Science 2025-06-23 Abinitha Gourabathina , Yuexing Hao , Walter Gerych , Marzyeh Ghassemi

While large language models (LLMs) achieve near-perfect scores on medical licensing exams, these evaluations inadequately reflect the complexity and diversity of real-world clinical practice. We introduce MedHELM, an extensible evaluation…

Large Language Models (LLMs) have revolutionized Natural Language Processing but exhibit limitations, particularly in autonomously addressing novel challenges such as reasoning and problem-solving. Traditional techniques like…

Multiagent Systems · Computer Science 2024-01-03 Sumedh Rasal

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

Artificial Intelligence · Computer Science 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang

Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Machine Learning · Computer Science 2025-11-17 Namkyeong Lee , Edward De Brouwer , Ehsan Hajiramezanali , Tommaso Biancalani , Chanyoung Park , Gabriele Scalia

The rapid advancement of large language models (LLMs) has accelerated their integration into clinical decision support, particularly in prescription review. To enable systematic and fine-grained evaluation, we developed RxBench, a…

Computation and Language · Computer Science 2025-12-03 Yan Yang , Mouxiao Bian , Peiling Li , Bingjian Wen , Ruiyao Chen , Kangkun Mao , Xiaojun Ye , Tianbin Li , Pengcheng Chen , Bing Han , Jie Xu , Kaifeng Qiu , Junyan Wu

Effective patient-provider communication is difficult to assess at scale. We examine whether large language models (LLMs) can track 20 social behaviors from clinical transcripts without fine-tuning. Across three model families and multiple…

Computation and Language · Computer Science 2026-05-14 Manas Satish Bedmutha , Feng Chen , Andrea Hartzler , Trevor Cohen , Nadir Weibel

Lifelong learning is essential for intelligent agents operating in dynamic environments. Current large language model (LLM)-based agents, however, remain stateless and unable to accumulate or transfer knowledge over time. Existing…

Artificial Intelligence · Computer Science 2025-06-02 Junhao Zheng , Xidi Cai , Qiuke Li , Duzhen Zhang , ZhongZhi Li , Yingying Zhang , Le Song , Qianli Ma

Customer Relationship Management (CRM) systems are vital for modern enterprises, providing a foundation for managing customer interactions and data. Integrating AI agents into CRM systems can automate routine processes and enhance…

Computation and Language · Computer Science 2025-02-18 Kung-Hsiang Huang , Akshara Prabhakar , Sidharth Dhawan , Yixin Mao , Huan Wang , Silvio Savarese , Caiming Xiong , Philippe Laban , Chien-Sheng Wu

Matching patients to clinical trials is a key unsolved challenge in bringing new drugs to market. Today, identifying patients who meet a trial's eligibility criteria is highly manual, taking up to 1 hour per patient. Automated screening is…

Computation and Language · Computer Science 2024-04-11 Michael Wornow , Alejandro Lozano , Dev Dash , Jenelle Jindal , Kenneth W. Mahaffey , Nigam H. Shah

Large language models (LLMs) show promise for healthcare question answering, but clinical use is limited by weak verification, insufficient evidence grounding, and unreliable confidence signalling. We propose a multi-agent medical QA…

Computation and Language · Computer Science 2026-02-17 Naeimeh Nourmohammadi , Md Meem Hossain , The Anh Han , Safina Showkat Ara , Zia Ush Shamszaman