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Computer simulations are invaluable tools for scientific discovery. However, accurate simulations are often slow to execute, which limits their applicability to extensive parameter exploration, large-scale data analysis, and uncertainty…

In this paper, we develop invariance-based procedures for testing and inference in high-dimensional regression models. These procedures, also known as randomization tests, provide several important advantages. First, for the global null…

Methodology · Statistics 2023-12-27 Wenxuan Guo , Panos Toulis

Machine learning models are being used extensively in many important areas, but there is no guarantee a model will always perform well or as its developers intended. Understanding the correctness of a model is crucial to prevent potential…

Machine Learning · Computer Science 2021-04-13 Huong Ha , Sunil Gupta , Santu Rana , Svetha Venkatesh

A key objective in spatial statistics is to simulate from the distribution of a spatial process at a selection of unobserved locations conditional on observations (i.e., a predictive distribution) to enable spatial prediction and…

Methodology · Statistics 2025-11-17 Julia Walchessen , Andrew Zammit-Mangion , Raphaël Huser , Mikael Kuusela

We can, and should, do statistical inference on simulation models by adjusting the parameters in the simulation so that the values of {\em randomly chosen} functions of the simulation output match the values of those same functions…

Methodology · Statistics 2021-11-18 Cosma Rohilla Shalizi

Statistical inference is the science of drawing conclusions about some system from data. In modern signal processing and machine learning, inference is done in very high dimension: very many unknown characteristics about the system have to…

Disordered Systems and Neural Networks · Physics 2020-10-29 Jean Barbier

To model modern large-scale datasets, we need efficient algorithms to infer a set of $P$ unknown model parameters from $N$ noisy measurements. What are fundamental limits on the accuracy of parameter inference, given finite signal-to-noise…

Machine Learning · Statistics 2016-09-07 Madhu Advani , Surya Ganguli

This work addresses the inverse identification of apparent elastic properties of random heterogeneous materials using machine learning based on artificial neural networks. The proposed neural network-based identification method requires the…

Machine Learning · Computer Science 2021-02-12 Florent Pled , Christophe Desceliers , Tianyu Zhang

Selection bias arises when the probability that an observation enters a dataset depends on variables related to the quantities of interest, leading to systematic distortions in estimation and uncertainty quantification. For example, in…

The objective of this work is to quantify the uncertainty in probability of failure estimates resulting from incomplete knowledge of the probability distributions for the input random variables. We propose a framework that couples the…

Methodology · Statistics 2021-10-26 Dimitris G. Giovanis , Michael Shields

High-dimensional group inference is an essential part of statistical methods for analysing complex data sets, including hierarchical testing, tests of interaction, detection of heterogeneous treatment effects and inference for local…

Methodology · Statistics 2020-12-01 Zijian Guo , Claude Renaux , Peter Bühlmann , T. Tony Cai

Simulation-based inference (SBI) enables parameter inference by training neural networks on forward simulations. It is being applied both for intractable likelihoods as well as under time constraints on the posterior sampling. After…

Cosmology and Nongalactic Astrophysics · Physics 2026-05-12 Leander Thiele

Inverse problems and, in particular, inferring unknown or latent parameters from data are ubiquitous in engineering simulations. A predominant viewpoint in identifying unknown parameters is Bayesian inference where both prior information…

Computation · Statistics 2022-08-31 Vahid Keshavarzzadeh , Robert M. Kirby , Akil Narayan

Likelihood-free inference refers to inference when a likelihood function cannot be explicitly evaluated, which is often the case for models based on simulators. Most of the literature is based on sample-based `Approximate Bayesian…

Machine Learning · Statistics 2018-11-22 Conor Durkan , George Papamakarios , Iain Murray

Within scientific and real life problems, classification is a typical case of extremely complex tasks in data-driven scenarios, especially if approached with traditional techniques. Machine Learning supervised and unsupervised paradigms,…

Instrumentation and Methods for Astrophysics · Physics 2018-07-13 Giuseppe Angora , Massimo Brescia , Stefano Cavuoti , Giuseppe Riccio , Maurizio Paolillo , Thomas H. Puzia

The ATLAS experiment at the Large Hadron Collider explores the use of modern neural networks for a multi-dimensional calibration of its calorimeter signal defined by clusters of topologically connected cells (topo-clusters). The Bayesian…

High Energy Physics - Experiment · Physics 2026-02-03 ATLAS Collaboration

Complex statistical models such as scalar-on-image regression often require strong assumptions to overcome the issue of non-identifiability. While in theory it is well understood that model assumptions can strongly influence the results,…

Methodology · Statistics 2020-05-04 Clara Happ , Sonja Greven , Volker J. Schmid

Prediction algorithms, such as deep neural networks (DNNs), are used in many domain sciences to directly estimate internal parameters of interest in simulator-based models, especially in settings where the observations include images or…

Machine Learning · Statistics 2023-11-14 Luca Masserano , Tommaso Dorigo , Rafael Izbicki , Mikael Kuusela , Ann B. Lee

When analyzing real-world data it is common to work with event ensembles, which comprise sets of observations that collectively constrain the parameters of an underlying model of interest. Such models often have a hierarchical structure,…

Machine Learning · Statistics 2024-02-22 Lukas Heinrich , Siddharth Mishra-Sharma , Chris Pollard , Philipp Windischhofer

Cosmic-ray acceleration processes in astrophysical plasmas are often investigated with fully-kinetic or hybrid kinetic numerical simulations, which enable us to describe a detailed microphysics of particle energization mechanisms. Tracing…

High Energy Astrophysical Phenomena · Physics 2025-02-12 Gabriel Torralba Paz , Artem Bohdan , Jacek Niemiec