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Dimensionality reduction of spatial omic data can reveal shared, spatially structured patterns of expression across a collection of genomic features. We study strategies for discovering and interactively visualizing low-dimensional…

Applications · Statistics 2021-12-03 Tinghui Xu , Kris Sankaran

Large volumes of spatio-temporal data are increasingly collected and studied in diverse domains including, climate science, social sciences, neuroscience, epidemiology, transportation, mobile health, and Earth sciences. Spatio-temporal data…

Machine Learning · Computer Science 2017-11-20 Gowtham Atluri , Anuj Karpatne , Vipin Kumar

Spatial confounding is a persistent challenge in spatial statistics, influencing the validity of statistical inference in models that analyze spatially-structured data. The concept has been interpreted in various ways but is broadly defined…

Understanding the intricate cellular environment within biological tissues is crucial for uncovering insights into complex biological functions. While single-cell RNA sequencing has significantly enhanced our understanding of cellular…

Image and Video Processing · Electrical Eng. & Systems 2024-11-06 Bingjun Li , Mostafa Karami , Masum Shah Junayed , Sheida Nabavi

Multiplex immunofluorescence (mIF) imaging technology facilitates the study of the tumour microenvironment in cancer patients. Due to the capabilities of this emerging bioimaging technique, it is possible to statistically analyse, for…

Applications · Statistics 2023-07-07 Jonatan A. González , Julia Wrobel , Simon Vandekar , Paula Moraga

Continuous space species distribution models (SDMs) have a long-standing history as a valuable tool in ecological statistical analysis. Geostatistical and preferential models are both common models in ecology. Geostatistical models are…

Applications · Statistics 2023-07-17 Mario Figueira , David Conesa , Antonio López-Quílez , Iosu Paradinas

With continued advances in Geographic Information Systems and related computational technologies, statisticians are often required to analyze very large spatial datasets. This has generated substantial interest over the last decade, already…

Methodology · Statistics 2019-05-14 Lu Zhang , Abhirup Datta , Sudipto Banerjee

Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell…

Genomics · Quantitative Biology 2025-12-15 Hiren Madhu , João Felipe Rocha , Tinglin Huang , Siddharth Viswanath , Smita Krishnaswamy , Rex Ying

Spatial association and heterogeneity are two critical areas in the research about spatial analysis, geography, statistics and so on. Though large amounts of outstanding methods has been proposed and studied, there are few of them tend to…

Econometrics · Economics 2018-03-26 Zihao Yuan

Spatial optimization problems (SOPs) are characterized by spatial relationships governing the decision variables, objectives, and/or constraint functions. In this article, we focus on a specific type of SOP called spatial partitioning,…

Optimization and Control · Mathematics 2022-08-08 Subhodip Biswas , Fanglan Chen , Zhiqian Chen , Chang-Tien Lu , Naren Ramakrishnan

The Earth's surface is subject to complex and dynamic processes, ranging from large-scale phenomena such as tectonic plate movements to localized changes associated with ecosystems, agriculture, or human activity. Satellite images enable…

Computer Vision and Pattern Recognition · Computer Science 2026-03-02 Corentin Dufourg , Charlotte Pelletier , Stéphane May , Sébastien Lefèvre

Visual insights into a wide variety of statistical methods, for both didactic and data analytic purposes, can often be achieved through geometric diagrams and geometrically based statistical graphs. This paper extols and illustrates the…

Methodology · Statistics 2013-02-21 Michael Friendly , Georges Monette , John Fox

With systems for acquiring 3D surface data being evermore commonplace, it has become important to reliably extract specific shapes from the acquired data. In the presence of noise and occlusions, this can be done through the use of…

Computer Vision and Pattern Recognition · Computer Science 2015-03-30 Alan Brunton , Augusto Salazar , Timo Bolkart , Stefanie Wuhrer

Biological processes involve a variety of spatial and temporal scales. A holistic understanding of many biological processes therefore requires multi-scale models which capture the relevant properties on all these scales. In this manuscript…

Molecular Networks · Quantitative Biology 2015-06-23 Jan Hasenauer , Nick Jagiella , Sabrina Hross , Fabian J. Theis

With the rapid amassing of spatial-temporal (ST) ocean data, many spatial-temporal data mining (STDM) studies have been conducted to address various oceanic issues, including climate forecasting and disaster warning. Compared with typical…

Machine Learning · Computer Science 2026-04-28 Hanchen Yang , Wengen Li , Shuyu Wang , Hui Li , Jihong Guan , Shuigeng Zhou , Jiannong Cao

Spatial transcriptomics measures the expression of thousands of genes in a tissue sample while preserving its spatial structure. This class of technologies has enabled the investigation of the spatial variation of gene expressions and their…

Methodology · Statistics 2025-10-23 Andrea Sottosanti , Davide Risso , Francesco Denti

Stochastic Process Model has many applications in analysis of longitudinal biodemographic data. Such data contain various physiological variables (sometimes known as covariates). It also can potentially contain genetic information available…

Populations and Evolution · Quantitative Biology 2016-05-31 Ilya Zhbannikov , Konstantin Arbeev , Anatoliy Yashin

Spatial association measures for univariate static spatial data are widely used. When the data is in the form of a collection of spatial vectors with the same temporal domain of interest, we construct a measure of similarity between the…

Methodology · Statistics 2023-09-26 Divya Kappara , Arup Bose , Madhuchhanda Bhattacharjee

Spatial variable genes (SVGs) reveal critical information about tissue architecture, cellular interactions, and disease microenvironments. As spatial transcriptomics (ST) technologies proliferate, accurately identifying SVGs across diverse…

Applications · Statistics 2025-10-21 Jiawen Chen , Jinwei Zhang , Dongshen Peng , Yutong Song , Aitong Ruan , Yun Li , Didong Li

Visualizations support rapid analysis of scientific datasets, allowing viewers to glean aggregate information (e.g., the mean) within split-seconds. While prior research has explored this ability in conventional charts, it is unclear if…

Human-Computer Interaction · Computer Science 2024-06-21 Victor A. Mateevitsi , Michael E. Papka , Khairi Reda