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This paper explores uncertainty quantification (UQ) as an indicator of the trustworthiness of automated deep-learning (DL) tools in the context of white matter lesion (WML) segmentation from magnetic resonance imaging (MRI) scans of…

Deep learning models for semantic segmentation are prone to poor performance in real-world applications due to the highly challenging nature of the task. Model uncertainty quantification (UQ) is one way to address this issue of lack of…

Computer Vision and Pattern Recognition · Computer Science 2022-11-04 Rishabh Singh , Jose C. Principe

White Matter Hyperintensities (WMH) are areas of the brain that have higher intensity than other normal brain regions on Magnetic Resonance Imaging (MRI) scans. WMH is often associated with small vessel disease in the brain, making early…

Image and Video Processing · Electrical Eng. & Systems 2023-05-09 Muhammad Noor Dwi Eldianto , Muhammad Febrian Rachmadi , Wisnu Jatmiko

Machine learning algorithms underpin modern diagnostic-aiding software, which has proved valuable in clinical practice, particularly in radiology. However, inaccuracies, mainly due to the limited availability of clinical samples for…

White matter hyperintensities (WMH) are radiological markers of small vessel disease and neurodegeneration, whose accurate segmentation and spatial localization are crucial for diagnosis and monitoring. While multimodal MRI offers…

Image and Video Processing · Electrical Eng. & Systems 2025-06-30 Julia Machnio , Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

The accurate assessment of White matter hyperintensities (WMH) burden is of crucial importance for epidemiological studies to determine association between WMHs, cognitive and clinical data. The manual delineation of WMHs is tedious, costly…

Tissues and Organs · Quantitative Biology 2018-01-03 R. Guerrero , C. Qin , O. Oktay , C. Bowles , L. Chen , R. Joules , R. Wolz , M. C. Valdes-Hernandez , D. A. Dickie , J. Wardlaw , D. Rueckert

Brain atrophy and white matter hyperintensity (WMH) are critical neuroimaging features for ascertaining brain injury in cerebrovascular disease and multiple sclerosis. Automated segmentation and quantification is desirable but existing…

White matter hyperintensities (WMH) are key imaging markers in cognitive aging, Alzheimer's disease (AD), and related dementias. Although automated methods for WMH segmentation have advanced, most provide only global lesion load and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Julia Machnio , Mads Nielsen , Mostafa Mehdipour Ghazi

Segmentation and quantification of white matter hyperintensities (WMHs) are of great importance in studying and understanding various neurological and geriatric disorders. Although automatic methods have been proposed for WMH segmentation…

Computer Vision and Pattern Recognition · Computer Science 2018-03-20 Dakai Jin , Ziyue Xu , Adam P. Harrison , Daniel J. Mollura

The relationship between cognition and white matter hyperintensities (WMH) volumes often depends on the accuracy of the lesion segmentation algorithm used. As such, accurate detection and quantification of WMH is of great interest. Here, we…

Image and Video Processing · Electrical Eng. & Systems 2020-12-25 Lavanya Umapathy , Gloria Guzman Perez-Carillo , Blair Winegar , Srinivasan Vedantham , Maria Altbach , Ali Bilgin

White Matter Hyperintensity (WMH) is an imaging feature related to various diseases such as dementia and stroke. Accurately segmenting WMH using computer technology is crucial for early disease diagnosis. However, this task remains…

Image and Video Processing · Electrical Eng. & Systems 2025-07-08 Changlu Guo

The hybrid neural differentiable models mark a significant advancement in the field of scientific machine learning. These models, integrating numerical representations of known physics into deep neural networks, offer enhanced predictive…

Machine Learning · Computer Science 2024-01-02 Deepak Akhare , Tengfei Luo , Jian-Xun Wang

Uncertainty quantification (UQ) has become critical for evaluating the reliability of artificial intelligence systems, especially in medical image segmentation. This study addresses the interpretability of instance-wise uncertainty values…

Large language models (LLMs) exhibit impressive fluency, but often produce critical errors known as "hallucinations". Uncertainty quantification (UQ) methods are a promising tool for coping with this fundamental shortcoming. Yet, existing…

Uncertainty Quantification (UQ) is pivotal in enhancing the robustness, reliability, and interpretability of Machine Learning (ML) systems for healthcare, optimizing resources and improving patient care. Despite the emergence of ML-based…

Machine Learning · Computer Science 2025-05-07 L. Julián Lechuga López , Shaza Elsharief , Dhiyaa Al Jorf , Firas Darwish , Congbo Ma , Farah E. Shamout

Accurate lesion segmentation is crucial for clinical diagnosis and treatment planning. However, lesions often resemble surrounding tissues and exhibit ill-defined boundaries, leading to unstable predictions in boundary/transition regions.…

Computer Vision and Pattern Recognition · Computer Science 2026-05-01 Shuokun Cheng , Jinghao Shi , Kun Sun

Emergence of artificial intelligence techniques in biomedical applications urges the researchers to pay more attention on the uncertainty quantification (UQ) in machine-assisted medical decision making. For classification tasks, prior…

Machine Learning · Computer Science 2019-09-17 Xiaoyang Huang , Jiancheng Yang , Linguo Li , Haoran Deng , Bingbing Ni , Yi Xu

Early detection of dementia through specific biomarkers in MR images plays a critical role in developing support strategies proactively. Fazekas scale facilitates an accurate quantitative assessment of the severity of white matter lesions…

In principle, deep learning models trained on medical time-series, including wearable photoplethysmography (PPG) sensor data, can provide a means to continuously monitor physiological parameters outside of clinical settings. However, there…

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