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Energy landscape analysis is a data-driven method to analyze multidimensional time series, including functional magnetic resonance imaging (fMRI) data. It has been shown to be a useful characterization of fMRI data in health and disease. It…

Neurons and Cognition · Quantitative Biology 2024-08-21 Pitambar Khanra , Johan Nakuci , Sarah Muldoon , Takamitsu Watanabe , Naoki Masuda

Computational neuroscience models have been used for understanding neural dynamics in the brain and how they may be altered when physiological or other conditions change. We review and develop a data-driven approach to neuroimaging data…

Neurons and Cognition · Quantitative Biology 2017-05-26 Takahiro Ezaki , Takamitsu Watanabe , Masayuki Ohzeki , Naoki Masuda

The inverse Ising problem and its generalizations to Potts and continuous spin models have recently attracted much attention thanks to their successful applications in the statistical modeling of biological data. In the standard setting,…

Quantitative Methods · Quantitative Biology 2017-03-06 Pierre Barrat-Charlaix , Matteo Figliuzzi , Martin Weigt

Energy landscape models characterize neural dynamics by assigning energy values to each brain state that reflect their stability or probability of occurrence. The conventional energy landscape models rely on binary brain state…

Signal Processing · Electrical Eng. & Systems 2026-01-13 Triet M. Tran , Seyed Majid Razavi , Dee H. Wu , Sina Khanmohammadi

Machine learning techniques are being increasingly used as flexible non-linear fitting and prediction tools in the physical sciences. Fitting functions that exhibit multiple solutions as local minima can be analysed in terms of the…

The ability to explain decisions made by machine learning models remains one of the most significant hurdles towards widespread adoption of AI in highly sensitive areas such as medicine, cybersecurity or autonomous driving. Great interest…

Machine Learning · Computer Science 2024-12-17 Maximilian P Niroomand , David J Wales

An oft-used concept in modeling macromolecules is the free energy landscape, obtained by coarse-graining a vast number of microstates into a low-dimensional mesh of mesostates. If the landscape contains two or more local minima…

Statistical Mechanics · Physics 2018-04-24 Daniel Sigg , Vincent A. Voelz , Vincenzo Carnevale

Energy landscapes play a crucial role in shaping dynamics of many real-world complex systems. System evolution is often modeled as particles moving on a landscape under the combined effect of energy-driven drift and noise-induced diffusion,…

Computational Engineering, Finance, and Science · Computer Science 2025-03-04 Ruikun Li , Huandong Wang , Qingmin Liao , Yong Li

Many problems in physics, material sciences, chemistry and biology can be abstractly formulated as a system that navigates over a complex energy landscape of high or infinite dimensions. Well-known examples include phase transitions of…

Numerical Analysis · Mathematics 2025-10-20 Weinan E , Weiqing Ren , Eric Vanden-Eijnden

The maximum-weight matching problem and the behavior of its energy landscape is numerically investigated. We apply a perturbation method adapted from the analysis of spin glasses. This gives inside into the complexity of the energy…

Disordered Systems and Neural Networks · Physics 2023-04-04 Till Kahlke , Alexander K. Hartmann

Physics-based Ising machines (IM) have been developed as dedicated processors for solving hard combinatorial optimization problems with higher speed and better energy efficiency. Generally, such systems employ local search heuristics to…

Disordered Systems and Neural Networks · Physics 2024-10-22 Dmitrii Dobrynin , Adrien Renaudineau , Mohammad Hizzani , Dmitri Strukov , Masoud Mohseni , John Paul Strachan

In many statistical learning problems, the target functions to be optimized are highly non-convex in various model spaces and thus are difficult to analyze. In this paper, we compute \emph{Energy Landscape Maps} (ELMs) which characterize…

Machine Learning · Statistics 2014-10-03 Maria Pavlovskaia , Kewei Tu , Song-Chun Zhu

Energy landscapes provide a valuable means for studying the folding dynamics of short RNA molecules in detail by modeling all possible structures and their transitions. Higher abstraction levels based on a macro-state decomposition of the…

Biomolecules · Quantitative Biology 2014-09-09 Martin Mann , Marcel Kucharik , Christoph Flamm , Michael T. Wolfinger

The Lenz-Ising model has served for almost a century as a basis for understanding ferromagnetism, and has become a paradigmatic model for phase transitions in statistical mechanics. While retaining the Ising energy arguments, we use…

Statistical Mechanics · Physics 2013-06-18 Haley A. Yaple , Daniel M. Abrams

A novel method for glassy landscape exploration is presented which utilizes a time series of energy values collected during an isothermal relaxation after a thermal quench. A sub-series of increasingly rare events, or quakes, which are…

Statistical Mechanics · Physics 2007-05-23 Paolo Sibani , Jesper Dall

A variety of methods are developed for characterising the free energy landscapes of continuum, Landau-type free energy models. Using morphologies of lipid vesicles and a multistable liquid crystal device as examples, I show that the methods…

Soft Condensed Matter · Physics 2015-06-23 Halim Kusumaatmaja

Optimizing energy consumption for robot navigation in fields requires energy-cost maps. However, obtaining such a map is still challenging, especially for large, uneven terrains. Physics-based energy models work for uniform, flat surfaces…

Robotics · Computer Science 2022-12-14 Minghan Wei , Volkan Isler

We describe a reverse integration approach for the exploration of low-dimensional effective potential landscapes. Coarse reverse integration initialized on a ring of coarse states enables efficient "navigation" on the landscape terrain:…

Chemical Physics · Physics 2015-05-13 Thomas A. Frewen , Gerhard Hummer , Ioannis G. Kevrekidis

This work maps deep neural networks to classical Ising spin models, allowing them to be described using statistical thermodynamics. The density of states shows that structures emerge in the weights after they have been trained --…

Statistical Mechanics · Physics 2022-09-20 Dusan Stosic , Darko Stosic , Borko Stosic

Dynamical energy analysis was recently introduced as a new method for determining the distribution of mechanical and acoustic wave energy in complex built up structures. The technique interpolates between standard statistical energy…

Computational Physics · Physics 2012-08-21 David J. Chappell , Gregor Tanner , Stefano Giani
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