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Fluorescence microscopy is a powerful tool for imaging biological samples with molecular specificity. In contrast, phase microscopy provides label-free measurement of the sample's refractive index (RI), which is an intrinsic optical…

Optics · Physics 2022-01-26 Yi Xue , David Ren , Laura Waller

Complex problems may require sophisticated, non-linear learning methods such as kernel machines or deep neural networks to achieve state of the art prediction accuracies. However, high prediction accuracies are not the only objective to…

Artificial Intelligence · Computer Science 2016-11-24 Marina M. -C. Vidovic , Nico Görnitz , Klaus-Robert Müller , Marius Kloft

Full-waveform inversion (FWI) is a widely used technique in seismic processing to produce high resolution Earth models that fully explain the recorded seismic data. FWI is a local optimisation problem which aims to minimise in a…

Geophysics · Physics 2019-11-22 Christopher Zerafa , Pauline Galea , Cristiana Sebu

Histologic examination plays a crucial role in oncology research and diagnostics. The adoption of digital scanning of whole slide images (WSI) has created an opportunity to leverage deep learning-based image classification methods to…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Md Zahangir Alom , Quynh T. Tran , Brent A. Orr

Histopathological image classification constitutes a pivotal task in computer-aided diagnostics. The precise identification and categorization of histopathological images are of paramount significance for early disease detection and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Weiping Ding , Tianyi Zhou , Jiashuang Huang , Shu Jiang , Tao Hou , Chin-Teng Lin

Significant progress has been made for estimating optical flow using deep neural networks. Advanced deep models achieve accurate flow estimation often with a considerable computation complexity and time-consuming training processes. In this…

Computer Vision and Pattern Recognition · Computer Science 2020-06-23 Lingtong Kong , Jie Yang

Interpreting scattered acoustic and electromagnetic wave patterns is a computational task that enables remote imaging in a number of important applications, including medical imaging, geophysical exploration, sonar and radar detection, and…

Computational Physics · Physics 2025-04-03 Owen Melia , Olivia Tsang , Vasileios Charisopoulos , Yuehaw Khoo , Jeremy Hoskins , Rebecca Willett

Localization of anatomical landmarks is essential for clinical diagnosis, treatment planning, and research. In this paper, we propose a novel deep network, named feature aggregation and refinement network (FARNet), for the automatic…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 Yueyuan Ao , Hong Wu

Significance: Optical neuroimaging has become a well-established clinical and research tool to monitor cortical activations in the human brain. It is notable that outcomes of functional Near-InfraRed Spectroscopy (fNIRS) studies depend…

Neurons and Cognition · Quantitative Biology 2023-01-03 Condell Eastmond , Aseem Subedi , Suvranu De , Xavier Intes

Photoluminesce (PL) spectroscopy offers excellent methods for mapping the PL decay on the nanosecond time scale. However, capturing maps of emission dynamics on the microsecond time scale can be highly time-consuming. We present a new…

Optics · Physics 2021-02-24 Jiri Junek , Karel Zidek

Accurate, noninvasive detection of isocitrate dehydrogenase (IDH) mutation is essential for effective glioma management. Traditional methods rely on invasive tissue sampling, which may fail to capture a tumor's spatial heterogeneity. While…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Somayeh Farahani , Marjaneh Hejazi , Antonio Di Ieva , Sidong Liu

Fluorescent imaging plays a critical role in a myriad of scientific endeavors, particularly in the biological sciences. Three-dimensional imaging of fluorescent intensity often requires serial data acquisition, that is voxel-by-voxel…

Optics · Physics 2015-10-27 Jeffrey J. Field , David G. Winters , Randy A. Bartels

Hyperspectral images (HSI) have become popular for analysing remotely sensed images in multiple domain like agriculture, medical. However, existing models struggle with complex relationships and characteristics of spectral-spatial data due…

Computer Vision and Pattern Recognition · Computer Science 2023-12-21 Neetu Sigger , Tuan Thanh Nguyen , Gianluca Tozzi , Quoc-Tuan Vien , Sinh Van Nguyen

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder involving motor neuron degeneration. Significant research has begun to establish brain magnetic resonance imaging (MRI) as a potential biomarker to diagnose and…

Finding an appropriate representation of dynamic activities in the brain is crucial for many downstream applications. Due to its highly dynamic nature, temporally averaged fMRI (functional magnetic resonance imaging) can only provide a…

Machine Learning · Computer Science 2022-08-18 Sikun Lin , Shuyun Tang , Scott Grafton , Ambuj Singh

While deep learning has seen many recent applications to drug discovery, most have focused on predicting activity or toxicity directly from chemical structure. Phenotypic changes exhibited in cellular images are also indications of the…

Computer Vision and Pattern Recognition · Computer Science 2019-03-18 Philip T. Jackson , Yinhai Wang , Sinead Knight , Hongming Chen , Thierry Dorval , Martin Brown , Claus Bendtsen , Boguslaw Obara

Recent advancements have showcased the potential of handheld millimeter-wave (mmWave) imaging, which applies synthetic aperture radar (SAR) principles in portable settings. However, existing studies addressing handheld motion errors either…

Computer Vision and Pattern Recognition · Computer Science 2024-05-07 Yadong Li , Dongheng Zhang , Ruixu Geng , Jincheng Wu , Yang Hu , Qibin Sun , Yan Chen

CTR prediction has been widely used in the real world. Many methods model feature interaction to improve their performance. However, most methods only learn a fixed representation for each feature without considering the varying importance…

Information Retrieval · Computer Science 2022-12-02 Fangye Wang , Yingxu Wang , Dongsheng Li , Hansu Gu , Tun Lu , Peng Zhang , Ning Gu

This thesis centres on the development of multidimensional fluorescence imaging tools, with a particular emphasis on fluorescence lifetime imaging (FLIM) microscopy for application to biological research. The key aspects of this thesis are…

Instrumentation and Detectors · Physics 2017-08-14 Egidijus Auksorius

We have developed an automatic method for segmenting fluorescence lifetime (FLT) imaging microscopy (FLIM) images of cells inspired by a multi-resolution community detection (MCD) based network segmentation method. The image processing…

Medical Physics · Physics 2014-01-06 Dandan Hu , Pinaki Sarder , Peter Ronhovde , Sandra Orthaus , Samuel Achilefu , Zohar Nussinov