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Computational methods are the most effective tools we have besides scientific experiments to explore the properties of complex biological systems. Progress is slowing because digital silicon computers have reached their limits in terms of…

Quantum Physics · Physics 2020-04-03 Viv Kendon

Quantum mechanical problems are among the hardest to simulate and, in some cases, remain intractable even for the most powerful computers. Quantum computing has emerged as a new technological platform to address such challenges, with rapid…

Quantum Physics · Physics 2025-09-01 Alexander Miessen

Hybrid quantum and classical learning aims to couple quantum feature maps with the robustness of classical neural networks, yet most architectures treat the quantum circuit as an isolated feature extractor and merge its measurements with…

Machine Learning · Computer Science 2025-12-23 Azadeh Alavi , Fatemeh Kouchmeshki , Abdolrahman Alavi

Despite years of effort, the quantum machine learning community has only been able to show quantum learning advantages for certain contrived cryptography-inspired datasets in the case of classical data. In this note, we discuss the…

Quantum Physics · Physics 2023-07-06 Casper Gyurik , Vedran Dunjko

In the effort to develop useful quantum computers simulating quantum machines with conventional computing resources is a key capability. Such simulations will always face limits preventing the emulation of quantum computers of substantial…

Quantum Physics · Physics 2023-02-20 Xiaosi Xu , Simon Benjamin , Jinzhao Sun , Xiao Yuan , Pan Zhang

Optimization problems is one of the most challenging applications of quantum computers, as well as one of the most relevants. As a consequence, it has attracted huge efforts to obtain a speedup over classical algorithms using quantum…

Quantum computing (QC) has gained significant attention over the past two decades due to its potential for speeding up classically demanding tasks. This transition from an academic focus to a thriving commercial sector is reflected in…

Scaling bottlenecks the making of digital quantum computers, posing challenges from both the quantum and the classical components. We present a classical architecture to cope with a comprehensive list of the latter challenges {\em all at…

Increasingly deeper integration of HPC resources and QPUs unveils new challenges in computer architecture and engineering. As a consequence, dependability arises again as a concern encompassing resilience, reproducibility and security. The…

Quantum Physics · Physics 2026-03-10 Santiago Núñez-Corrales

Quantum algorithms for simulating large and complex molecular systems are still in their infancy, and surpassing state-of-the-art classical techniques remains an ever-receding goal post. A promising avenue of inquiry in the meanwhile is to…

Quantum Physics · Physics 2025-08-07 Soohaeng Yoo Willow , D. ChangMo Yang , Chang Woo Myung

While recent progress in quantum hardware open the door for significant speedup in certain key areas (cryptography, biology, chemistry, optimization, machine learning, etc), quantum algorithms are still hard to implement right, and the…

Programming Languages · Computer Science 2022-04-11 Christophe Chareton , Sébastien Bardin , Dongho Lee , Benoît Valiron , Renaud Vilmart , Zhaowei Xu

The emergence of quantum computing proposes a revolutionary paradigm that can radically transform numerous scientific and industrial application domains. The ability of quantum computers to scale computations implies better performance and…

Software Engineering · Computer Science 2024-03-29 Vlad Stirbu , Majid Haghparast

A quantum computer (QC) can solve many computational problems more efficiently than a classic one. The field of QCs is growing: companies (such as DWave, IBM, Google, and Microsoft) are building QC offerings. We position that software…

Software Engineering · Computer Science 2019-07-09 Andriy Miranskyy , Lei Zhang

The intensive pursuit for quantum advantage in terms of computational complexity has further led to a modernized crucial question: {\it When and how will quantum computers outperform classical computers?} The next milestone is undoubtedly…

Quantum Physics · Physics 2024-05-07 Nobuyuki Yoshioka , Tsuyoshi Okubo , Yasunari Suzuki , Yuki Koizumi , Wataru Mizukami

Advancements in classical computing have significantly enhanced machine learning applications, yet inherent limitations persist in terms of energy, resource and speed. Quantum machine learning algorithms offer a promising avenue to overcome…

Quantum Physics · Physics 2025-02-18 Tarun Dutta , Alex Jin , Clarence Liu Huihong , J I Latorre , Manas Mukherjee

Current technologies in quantum-based communications bring a new integration of quantum data with classical data for hybrid processing. However, the frameworks of these technologies are restricted to a single classical or quantum task,…

Quantum Physics · Physics 2022-09-02 Quoc Hoan Tran , Sanjib Ghosh , Kohei Nakajima

The complexity of biological systems, governed by molecular interactions across hierarchical scales, presents a challenge for computational modeling. While advances in multiomic profiling have enabled precise measurements of biological…

Quantum Physics · Physics 2025-06-18 Michael Kubal , Sonika Johri

Search is one of the most commonly used primitives in quantum algorithm design. It is known that quadratic speedups provided by Grover's algorithm are optimal, and no faster quantum algorithms for Search exist. While it is known that at…

Quantum Physics · Physics 2023-06-07 Ansis Rosmanis

Major players in the global aerospace industry are shifting their focus toward achieving net carbon-neutral operations by 2050. A considerable portion of the overall carbon emission reduction is expected to come from new aircraft…

The practical application of quantum technologies to chemical problems faces significant challenges, particularly in the treatment of realistic basis sets and the accurate inclusion of electron correlation effects. A direct approach to…