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It is well known that in the computational fluid dynamics simulations related to the cardiovascular system the enforcement of outflow boundary conditions is a crucial point. In fact, they highly affect the computed flow and a wrong setup…

Fluid Dynamics · Physics 2025-03-05 Zahra Mirzaiyan , Michele Girfoglio , Gianluigi Rozza

Computer modeling can provide quantitative insight into cardiac fluid dynamics phenomena that are not evident from standard imaging tools. We propose a new approach to modeling left ventricle fluid dynamics based on an image-driven…

The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data…

Fluid Dynamics · Physics 2014-07-29 S. Fortini , G. Querzoli , S. Espa , A. Cenedese

Understanding the formation, propagation, and breakdown of the main vortex ring (VR) is essential for characterizing left ventricular (LV) hemodynamics, as its dynamics have been linked to the onset and progression of cardiovascular…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Michael Neidlin , Jesus Garicano-Mena , Soledad Le Clainche

The heart is the central part of the cardiovascular network. Its role is to pump blood to various body organs. Many cardiovascular diseases occur due to an abnormal functioning of the heart. A diseased heart leads to severe complications…

Medical Physics · Physics 2024-11-19 Mahesh S. Nagargoje , Eneko Lazpita , Jesús Garicano-Mena , Soledad Le Clainche

Cardiac disease and clinical intervention may both lead to an increased risk for thrombosis events due to modified blood flow in the heart, and thereby a change in the mechanical stimuli of blood cells passing through the chambers of the…

We present a new computational model for the numerical simulation of blood flow in the human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian Eulerian formulation to account for the endocardium motion…

Morphology of cardiovascular tissue is influenced by the unsteady behavior of the blood flow and vice versa. Therefore, the pathogenesis of several cardiovascular diseases is directly affected by the blood-flow dynamics. Understanding flow…

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…

Three-dimensional cardiovascular fluid dynamics simulations typically require computation of several cardiac cycles before they reach a periodic solution, rendering them computationally expensive. Furthermore, there is currently no…

Computational Engineering, Finance, and Science · Computer Science 2021-06-28 Martin R. Pfaller , Jonathan Pham , Nathan M. Wilson , David W. Parker , Alison L. Marsden

Intracardiac flow patterns are shaped by the coupled motion of the cardiac chambers and heart valves and provide important information about cardiac function. However, clinical flow imaging remains limited by exam times, noise, resolution,…

Image and Video Processing · Electrical Eng. & Systems 2026-05-12 Fanwei Kong , Aaron Brown , Michael Loecher , Perry S. Choi , Lei Shi , Michael Ma , Daniel B. Ennis , Alison Marsden

Unnatural dynamics of the notorious vortex in the left ventricle is often associated with cardiac disease. Understanding how different cardiac diseases alter the flow physics in the left ventricle may therefore provide a powerful tool for…

Medical Physics · Physics 2019-03-18 Giuseppe Di Labbio , Lyes Kadem

The circulatory system, comprising the heart and blood vessels, is vital for nutrient transport, waste removal, and homeostasis. Traditional computational models often treat cardiac electromechanics and blood flow dynamics separately,…

Image-based computational fluid dynamics (CFD) has emerged as a powerful tool to study cardiovascular flows while 2D echocardiography (echo) is the most widely used non-invasive imaging modality for diagnosis of heart disease. Here, echo is…

Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. The contraction and relaxation of left ventricle (LV) is the main driving force of blood circulation. Altered LV hemodynamics is believed to be associated with…

Medical Physics · Physics 2019-11-04 Fanwei Kong , Christoph Augustin , Kevin Sack , Shawn Shadden

We study the formation of the mitral vortex ring during early diastolic filling in a patient-specific left ventricle (LV) using direct numerical simulation. The geometry of the left ventricle is reconstructed from Magnetic Resonance Imaging…

Fluid Dynamics · Physics 2015-05-30 Trung Le , Fotis Sotiropoulos , Dane Coffey , Daniel Keefe

This brief article accompanies a fluid dynamics video presenting the results of a large-eddy simulation of the flow in a realistic left heart. The left heart geometry, from the pulmonary veins to the aortic root, is extracted from medical…

Fluid Dynamics · Physics 2013-10-14 Christophe Chnafa , Simon Mendez , Franck Nicoud

Numerical simulations of real-world phenomena require a computational scheme and a computational domain. In the context of haemodynamics, the computational domain is the blood vessel network through which blood flows. Such networks contain…

Discrete Mathematics · Computer Science 2025-02-19 Jay Aodh Mackenzie , Megan Jeanne Miller , Nicholas Hill , Mette Olufsen

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

Machine Learning · Computer Science 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

One-dimensional (1D) blood flow simulations are extensively used in cardiovascular research due to their computational efficiency and effectiveness in analyzing pulse wave dynamics. Despite their versatility and simplicity, there is a lack…

Quantitative Methods · Quantitative Biology 2025-08-27 Daehyun Kim , Jeffrey Tithof
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