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This paper studies a distributionally robust portfolio optimization model with a cardinality constraint for limiting the number of invested assets. We formulate this model as a mixed-integer semidefinite optimization (MISDO) problem by…

Optimization and Control · Mathematics 2022-12-22 Ken Kobayashi , Yuichi Takano , Kazuhide Nakata

In this study we analyze linear mixed-integer programming problems, in which the distribution of the cost vector is only observable through a finite training data set. In contrast to the related studies, we assume that the number of random…

Optimization and Control · Mathematics 2022-05-20 Sergey S. Ketkov , Andrei S. Shilov

Although GRPO substantially enhances flow matching models in human preference alignment of image generation, methods such as FlowGRPO and DanceGRPO still exhibit inefficiency due to the necessity of sampling and optimizing over all…

Artificial Intelligence · Computer Science 2026-03-23 Junzhe Li , Yutao Cui , Tao Huang , Yinping Ma , Chun Fan , Yiming Cheng , Miles Yang , Zhao Zhong , Liefeng Bo

Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…

Quantitative Methods · Quantitative Biology 2024-09-19 Qingqing Wang , Chang Chang

Purpose: The importance of robust proton treatment planning to mitigate the impact of uncertainty is well understood. However, its computational cost grows with the number of uncertainty scenarios, prolonging the treatment planning process.…

Medical Physics · Physics 2023-05-01 Anqi Fu , Vicki T. Taasti , Masoud Zarepisheh

Medical image segmentation models can perform unevenly across subgroups. Most existing fairness methods focus on improving average subgroup performance, implicitly treating each subgroup as internally homogeneous. However, this can hide…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Yiqi Tian , Sangjoon Park , Bo Zeng , Pengfei Jin , Yujin Oh , Quanzheng Li

The problem of constrained reinforcement learning (CRL) holds significant importance as it provides a framework for addressing critical safety satisfaction concerns in the field of reinforcement learning (RL). However, with the introduction…

Machine Learning · Computer Science 2023-05-24 Chengbin Xuan , Feng Zhang , Faliang Yin , Hak-Keung Lam

Intelligent robots provide a new insight into efficiency improvement in industrial and service scenarios to replace human labor. However, these scenarios include dense and dynamic obstacles that make motion planning of robots challenging.…

Robotics · Computer Science 2021-02-08 Chengmin Zhou , Bingding Huang , Pasi Fränti

Text-to-Image Diffusion models excel at generating images from text prompts but often exhibit suboptimal alignment with content semantics, aesthetics, and human preferences. To address these limitations, this study proposes a novel…

Machine Learning · Computer Science 2025-05-19 Jianping Ye , Michel Wedel , Kunpeng Zhang

Clinical prediction models are increasingly used to support patient care, yet many deep learning-based approaches remain unstable, as their predictions can vary substantially when trained on different samples from the same population. Such…

Machine Learning · Computer Science 2026-02-13 Sara Matijevic , Christopher Yau

Treatment planning in radiotherapy is inherently a multi-criteria optimization (MCO) problem. Traditionally, the treatment's robustness is not formulated as a part of this decision making problem, but dealt with separately through margins…

Medical Physics · Physics 2026-03-27 Remo Cristoforetti , Philipp Süss , Tobias Becher , Niklas Wahl

Recently, reinforcement learning (RL) has been employed for improving generative image super-resolution (ISR) performance. However, the current efforts are focused on multi-step generative ISR, while one-step generative ISR remains…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Qiaosi Yi , Shuai Li , Rongyuan Wu , Lingchen Sun , Zhengqiang Zhang , Lei Zhang

The widespread adoption of on-board volumetric imaging in cancer radiotherapy has stimulated research efforts to develop online adaptive radiotherapy techniques to handle the inter-fraction variation of the patient's geometry. Such efforts…

Medical Physics · Physics 2015-05-14 Chunhua Men , Xuejun Gu , Dongju Choi , Amitava Majumdar , Ziyi Zheng , Klaus Mueller , Steve B. Jiang

Motion information from 4D medical imaging offers critical insights into dynamic changes in patient anatomy for clinical assessments and radiotherapy planning and, thereby, enhances the capabilities of 3D image analysis. However, inherent…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Xia Li , Runzhao Yang , Xiangtai Li , Antony Lomax , Ye Zhang , Joachim Buhmann

We study multistage distributionally robust optimization (DRO) to hedge against ambiguity in quantifying the underlying uncertainty of a problem. Recognizing that not all the realizations and scenario paths might have an "effect" on the…

Optimization and Control · Mathematics 2021-09-15 Hamed Rahimian , Guzin Bayraksan , Tito Homem-de-Mello

We summarize recent results and ongoing activities in mathematical algorithms and computer science methods related to proton computed tomography (pCT) and intensity-modulated particle therapy (IMPT) treatment planning. Proton therapy…

Medical Physics · Physics 2021-08-24 Yair Censor , Keith E. Schubert , Reinhard W. Schulte

Constrained convex optimization problems arise naturally in many real-world applications. One strategy to solve them in an approximate way is to translate them into a sequence of convex feasibility problems via the recently developed level…

Optimization and Control · Mathematics 2019-04-30 E. Bonacker , A. Gibali , K. -H. Küfer

In the treatment plan optimization for intensity modulated radiation therapy (IMRT), dose-deposition coefficient (DDC) matrix is often pre-computed to parameterize the dose contribution to each voxel in the volume of interest from each…

Medical Physics · Physics 2013-03-15 Zhen Tian , Masoud Zarepisheh , Xun Jia , Steve B. Jiang

Purpose: To demonstrate the feasibility of fast Monte Carlo (MC) based inverse biological planning for the treatment of head and neck tumors in spot-scanning proton therapy. Methods: Recently, a fast and accurate Graphics Processor Unit…

Medical Physics · Physics 2016-10-11 H. Wan Chan Tseung , J. Ma , C. R. Kreofsky , D. Ma , C. Beltran

This paper proposes distributed algorithms to solve robust convex optimization (RCO) when the constraints are affected by nonlinear uncertainty. We adopt a scenario approach by randomly sampling the uncertainty set. To facilitate the…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-01-16 Keyou You , Roberto Tempo , Pei Xie