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Deciphering how DNA sequence encodes gene regulation remains a central challenge in biology. Advances in machine learning and functional genomics have enabled sequence-to-function (seq2func) models that predict molecular regulatory readouts…

Genomics · Quantitative Biology 2026-02-03 Masayuki Nagai , Alan E. Murphy , Kaeli Rizzo , Peter K. Koo

Large Language Models (LLMs) have demonstrated remarkable proficiency across diverse tasks, exhibiting emergent properties such as semantic prompt comprehension, In-Context Learning (ICL), and Chain-of-Thought (CoT) reasoning. Despite their…

Computation and Language · Computer Science 2026-03-13 Yuling Jiao , Yanming Lai , Huazhen Lin , Wensen Ma , Houduo Qi , Defeng Sun

Mechanistic interpretability aims to understand the computational mechanisms underlying neural networks' capabilities in order to accomplish concrete scientific and engineering goals. Progress in this field thus promises to provide greater…

Many task domains require robots to interpret and act upon natural language commands which are given by people and which refer to the robot's physical surroundings. Such interpretation is known variously as the symbol grounding problem,…

Regardless of the marked differences between biological and artificial neural systems, one fundamental similarity is that they are essentially dynamical systems that can learn to imitate other dynamical systems, without knowing their…

Neurons and Cognition · Quantitative Biology 2019-11-06 Zhixin Lu , Danielle S. Bassett

Mechanistic interpretability produces circuit-level causal analyses of neural network behaviour, but discovered circuits often remain isolated experimental artefacts: there is no shared formal representation for what circuits compute, how…

Machine Learning · Computer Science 2026-05-21 Nura Aljaafari , Danilo S. Carvalho , Andre Freitas

Large language models (LLMs) show impressive abilities via few-shot prompting. Commercialized APIs such as OpenAI GPT-3 further increase their use in real-world language applications. However, the crucial problem of how to improve the…

Computation and Language · Computer Science 2023-02-16 Chenglei Si , Zhe Gan , Zhengyuan Yang , Shuohang Wang , Jianfeng Wang , Jordan Boyd-Graber , Lijuan Wang

Prompt engineering has emerged as a powerful technique for guiding large language models (LLMs) toward desired responses, significantly enhancing their performance across diverse tasks. Beyond their role as static predictors, LLMs…

Machine Learning · Computer Science 2025-03-27 Ryumei Nakada , Wenlong Ji , Tianxi Cai , James Zou , Linjun Zhang

Mechanistic interpretability (MI) seeks to uncover how language models (LMs) implement specific behaviors, yet measuring progress in MI remains challenging. The recently released Mechanistic Interpretability Benchmark (MIB; Mueller et al.,…

Computation and Language · Computer Science 2025-11-25 Dana Arad , Yonatan Belinkov , Hanjie Chen , Najoung Kim , Hosein Mohebbi , Aaron Mueller , Gabriele Sarti , Martin Tutek

In-context learning (ICL) derives its power from enabling Large Language Models to adapt to new tasks via prompt-based reasoning alone, entirely bypassing the need for parameter updates. Existing theories primarily study ICL in single-task…

Machine Learning · Computer Science 2026-05-28 Guangyu Li , Meng Ding , Lijie Hu

Mechanistic interpretability seeks to reverse-engineer neural network computations into human-understandable algorithms, yet extracting sparse computational circuits from billion-parameter language models remains challenging due to…

Machine Learning · Computer Science 2026-01-21 Mohammed Mudassir Uddin , Shahnawaz Alam , Mohammed Kaif Pasha

A basic question within the emerging field of mechanistic interpretability is the degree to which neural networks learn the same underlying mechanisms. In other words, are neural mechanisms universal across different models? In this work,…

Test-time compute is emerging as a new paradigm for enhancing language models' complex multi-step reasoning capabilities, as demonstrated by the success of OpenAI's o1 and o3, as well as DeepSeek's R1. Compared to explicit reasoning in…

Computation and Language · Computer Science 2025-06-03 Tianhe Lin , Jian Xie , Siyu Yuan , Deqing Yang

In-context Learning (ICL) is an emerging few-shot learning paradigm on Language Models (LMs) with inner mechanisms un-explored. There are already existing works describing the inner processing of ICL, while they struggle to capture all the…

Computation and Language · Computer Science 2025-02-21 Hakaze Cho , Mariko Kato , Yoshihiro Sakai , Naoya Inoue

Large language models exhibit sophisticated capabilities, yet understanding how they work internally remains a central challenge. A fundamental obstacle is that training selects for behavior, not circuitry, so many weight configurations can…

Machine Learning · Computer Science 2026-02-27 Joshua S. Schiffman

Mechanistic interpretability seeks to reverse engineer a trained neural network by identifying the minimal subset of internal components. We perform a mechanistic interpretability analysis of the Particle Transformer architecture, trained…

High Energy Physics - Phenomenology · Physics 2026-05-12 Saurabh Rai , Sanmay Ganguly

Imitation learning is an effective and safe technique to train robot policies in the real world because it does not depend on an expensive random exploration process. However, due to the lack of exploration, learning policies that…

Robotics · Computer Science 2021-06-24 Ajay Mandlekar , Danfei Xu , Roberto Martín-Martín , Silvio Savarese , Li Fei-Fei

In-context learning (ICL) is a type of prompting where a transformer model operates on a sequence of (input, output) examples and performs inference on-the-fly. In this work, we formalize in-context learning as an algorithm learning problem…

Machine Learning · Computer Science 2023-02-07 Yingcong Li , M. Emrullah Ildiz , Dimitris Papailiopoulos , Samet Oymak

Mechanistic interpretability aims to understand model behaviors in terms of specific, interpretable features, often hypothesized to manifest as low-dimensional subspaces of activations. Specifically, recent studies have explored subspace…

Machine Learning · Computer Science 2023-12-07 Aleksandar Makelov , Georg Lange , Neel Nanda

Mechanistic interpretability seeks to understand the neural mechanisms that enable specific behaviors in Large Language Models (LLMs) by leveraging causality-based methods. While these approaches have identified neural circuits that copy…

Computation and Language · Computer Science 2023-08-29 Vedant Palit , Rohan Pandey , Aryaman Arora , Paul Pu Liang
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