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Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Integrating large language models (LLMs) with knowledge graphs derived from domain-specific data represents an important advancement towards more powerful and factual reasoning. As these models grow more capable, it is crucial to enable…

Artificial Intelligence · Computer Science 2024-04-19 Stefan Dernbach , Khushbu Agarwal , Alejandro Zuniga , Michael Henry , Sutanay Choudhury

Fine-grained image-text alignment is a pivotal challenge in multimodal learning, underpinning key applications such as visual question answering, image captioning, and vision-language navigation. Unlike global alignment, fine-grained…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Jiale Liu , Haoming Zhou , Yishu Liu , Bingzhi Chen , Yuncheng Jiang

Large Language Models (LLMs) have demonstrated great performance in few-shot In-Context Learning (ICL) for a variety of generative and discriminative chemical design tasks. The newly expanded context windows of LLMs can further improve ICL…

Any entity in the visual world can be hierarchically grouped based on shared characteristics and mapped to fine-grained sub-categories. While Multi-modal Large Language Models (MLLMs) achieve strong performance on coarse-grained visual…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Hulingxiao He , Zijun Geng , Yuxin Peng

Large Language Models (LLMs) fine-tuned for specific domains exhibit strong performance; however, the underlying mechanisms by which this fine-tuning reshapes their parametric space are not well understood. Prior works primarily focus on…

Computation and Language · Computer Science 2025-10-13 Eshaan Tanwar , Deepak Nathani , William Yang Wang , Tanmoy Chakraborty

Vision language models (VLM) have demonstrated remarkable performance across various downstream tasks. However, understanding fine-grained visual-linguistic concepts, such as attributes and inter-object relationships, remains a significant…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Wujian Peng , Sicheng Xie , Zuyao You , Shiyi Lan , Zuxuan Wu

Multi-modal large language models (MLLMs) have shown remarkable abilities in various visual understanding tasks. However, MLLMs still struggle with fine-grained visual recognition (FGVR), which aims to identify subordinate-level categories…

Computer Vision and Pattern Recognition · Computer Science 2025-04-01 Hulingxiao He , Geng Li , Zijun Geng , Jinglin Xu , Yuxin Peng

Pre-trained large-scale language models (LLMs) excel at producing coherent articles, yet their outputs may be untruthful, toxic, or fail to align with user expectations. Current approaches focus on using reinforcement learning with human…

Computation and Language · Computer Science 2024-06-06 Dehong Xu , Liang Qiu , Minseok Kim , Faisal Ladhak , Jaeyoung Do

Inverse graphics -- the task of inverting an image into physical variables that, when rendered, enable reproduction of the observed scene -- is a fundamental challenge in computer vision and graphics. Successfully disentangling an image…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Peter Kulits , Haiwen Feng , Weiyang Liu , Victoria Abrevaya , Michael J. Black

Despite the promise of RLHF in aligning LLMs with human preferences, it often leads to superficial alignment, prioritizing stylistic changes over improving downstream performance of LLMs. Underspecified preferences could obscure directions…

Computation and Language · Computer Science 2024-03-22 Kyungjae Lee , Dasol Hwang , Sunghyun Park , Youngsoo Jang , Moontae Lee

Aligning large language models (LLMs) with human objectives is crucial for real-world applications. However, fine-tuning LLMs for alignment often suffers from unstable training and requires substantial computing resources. Test-time…

Artificial Intelligence · Computer Science 2024-11-05 Lingkai Kong , Haorui Wang , Wenhao Mu , Yuanqi Du , Yuchen Zhuang , Yifei Zhou , Yue Song , Rongzhi Zhang , Kai Wang , Chao Zhang

Humans possess the capability to comprehend diverse modalities and seamlessly transfer information between them. In this work, we introduce ModaVerse, a Multi-modal Large Language Model (MLLM) capable of comprehending and transforming…

Computer Vision and Pattern Recognition · Computer Science 2024-04-05 Xinyu Wang , Bohan Zhuang , Qi Wu

A drug molecule is a substance that changes the organism's mental or physical state. Every approved drug has an indication, which refers to the therapeutic use of that drug for treating a particular medical condition. While the Large…

Artificial Intelligence · Computer Science 2024-02-20 David Oniani , Jordan Hilsman , Chengxi Zang , Junmei Wang , Lianjin Cai , Jan Zawala , Yanshan Wang

The advent of large Vision-Language Models (VLMs) has significantly advanced multimodal tasks, enabling more sophisticated and accurate reasoning across various applications, including image and video captioning, visual question answering,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Hang Hua , Qing Liu , Lingzhi Zhang , Jing Shi , Zhifei Zhang , Yilin Wang , Jianming Zhang , Jiebo Luo

Prompting Large Language Models (LLMs), or providing context on the expected model of operation, is an effective way to steer the outputs of such models to satisfy human desiderata after they have been trained. But in rapidly evolving…

Machine Learning · Computer Science 2025-08-08 Younwoo Choi , Muhammad Adil Asif , Ziwen Han , John Willes , Rahul G. Krishnan

Models based on machine learning can enable accurate and fast molecular property predictions, which is of interest in drug discovery and material design. Various supervised machine learning models have demonstrated promising performance,…

Machine Learning · Computer Science 2022-12-15 Jerret Ross , Brian Belgodere , Vijil Chenthamarakshan , Inkit Padhi , Youssef Mroueh , Payel Das

Large Language Models (LLMs) have demonstrated remarkable adaptability, showcasing their capacity to excel in tasks for which they were not explicitly trained. However, despite their impressive natural language processing (NLP)…

Computation and Language · Computer Science 2023-09-08 Supun Manathunga , Isuru Hettigoda

The ability to follow instructions is crucial for Large Language Models (LLMs) to handle various real-world applications. Existing benchmarks primarily focus on evaluating pure response quality, rather than assessing whether the response…

Computation and Language · Computer Science 2024-06-06 Yuxin Jiang , Yufei Wang , Xingshan Zeng , Wanjun Zhong , Liangyou Li , Fei Mi , Lifeng Shang , Xin Jiang , Qun Liu , Wei Wang

Parameter-Efficient Fine-Tuning (PEFT) is a popular class of techniques that strive to adapt large models in a scalable and resource-efficient manner. Yet, the mechanisms underlying their training performance and generalization remain…

Machine Learning · Computer Science 2026-02-10 Zahra Rahimi Afzal , Tara Esmaeilbeig , Mojtaba Soltanalian , Mesrob I. Ohannessian