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The Quantum Approximate Optimization Algorithm (QAOA) is a promising algorithm for solving combinatorial optimization problems (COPs), with performance governed by variational parameters $\{\gamma_i, \beta_i\}_{i=0}^{p-1}$. While most prior…

Quantum Physics · Physics 2025-08-07 J. A. Montanez-Barrera , Kristel Michielsen

The Quantum approximate optimization algorithm (QAOA) is one of the most promising candidates for achieving quantum advantage through quantum-enhanced combinatorial optimization. In a typical QAOA setup, a set of quantum circuit parameters…

Quantum Physics · Physics 2021-06-15 Alexey Galda , Xiaoyuan Liu , Danylo Lykov , Yuri Alexeev , Ilya Safro

Quantum Approximate Optimization Algorithm (QAOA) is a promising framework for solving combinatorial optimization problems on near-term quantum devices. One such problem is the Minimum Dominating Set (MDS), which is known to be NP-hard.…

Quantum Physics · Physics 2026-03-17 Guanghui Li , Xiaohui Ni , Junjian Su , Sujuan Qin , Fenzhuo Guo , Bingjie Xu , Wei Huang , Fei Gao

Quantum approximate optimization algorithm (QAOA) has shown promise in solving combinatorial optimization problems by providing quantum speedup on near-term gate-based quantum computing systems. However, QAOA faces challenges for…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-24 Seongmin Kim , Vincent R. Pascuzzi , Zhihao Xu , Tengfei Luo , Eungkyu Lee , In-Saeng Suh

This research explores the integration of the Quantum Approximate Optimization Algorithm (QAOA) into Hybrid Quantum-HPC systems for solving the Max-Cut problem, comparing its performance with classical algorithms like brute-force search and…

Quantum Physics · Physics 2024-10-22 Ishan Patwardhan , Akhil Akkapelli

The Quantum Approximate Optimization Algorithm (QAOA) is a promising variational algorithm for solving combinatorial optimization problems on near-term devices. However, as the number of layers in a QAOA circuit increases, which is…

Machine Learning · Computer Science 2025-04-24 Owain Parry , Phil McMinn

High error rates and limited fidelity of quantum gates in near-term quantum devices are the central obstacles to successful execution of the Quantum Approximate Optimization Algorithm (QAOA). In this paper we introduce an…

Quantum Physics · Physics 2022-06-16 Ruslan Shaydulin , Alexey Galda

Many combinatorial optimization problems admit a maximin fairness variant, where the aim is to find a distribution over possible solutions which maximizes an expected worst-case outcome. However, the support for an optimal distribution may…

Quantum Physics · Physics 2026-04-17 Bao Bach , Cameron Ibrahim , Reuben Tate , Jad Salem , Stephan Eidenbenz , Ilya Safro

Combinatorial optimization problems on graphs have broad applications in science and engineering. The Quantum Approximate Optimization Algorithm (QAOA) is a method to solve these problems on a quantum computer by applying multiple rounds of…

Molecular docking plays a pivotal role in drug discovery and precision medicine, enabling us to understand protein functions and advance novel therapeutics. Here, we introduce a potential alternative solution to this problem, the…

Quantum Physics · Physics 2024-05-17 Qi-Ming Ding , Yi-Ming Huang , Xiao Yuan

The Quantum Approximate Optimization Algorithm (QAOA) was originally developed to solve combinatorial optimization problems, but has become a standard for assessing the performance of quantum computers. Fully descriptive benchmarking…

Quantum Physics · Physics 2024-02-29 Anthony M. Polloreno , Graeme Smith

The quantum approximate optimization algorithm (QAOA) has rapidly become a cornerstone of contemporary quantum algorithm development. Despite a growing range of applications, only a few results have been developed towards understanding the…

Quantum Physics · Physics 2020-03-11 V. Akshay , H. Philathong , M. E. S. Morales , J. Biamonte

Molecular docking is a critical process for drug discovery and challenging due to the complexity and size of biomolecular systems, where the optimal binding configuration of a drug to a target protein is determined. Hybrid classical-quantum…

Emerging Technologies · Computer Science 2025-03-07 Christos Papalitsas , Yanfei Guan , Shreyas Waghe , Athanasios Liakos , Ioannis Balatsos , Vassilios Pantazopoulos

The quantum approximate optimization algorithm (QAOA) is a leading candidate algorithm for solving optimization problems on quantum computers. However, the potential of QAOA to tackle classically intractable problems remains unclear. Here,…

The quantum approximate optimization algorithm~(QAOA) first proposed by Farhi et al. promises near-term applications based on its simplicity, universality, and provable optimality. A depth-p QAOA consists of p interleaved unitary…

Quantum Physics · Physics 2019-05-30 Murphy Yuezhen Niu , Sirui Lu , Isaac L. Chuang

Protein folding -- the problem of predicting the spatial structure of a protein given its sequence of amino-acids -- has attracted considerable research effort in biochemistry in recent decades. In this work, we explore the potential of…

Quantum Physics · Physics 2022-04-06 Sami Boulebnane , Xavier Lucas , Agnes Meyder , Stanislaw Adaszewski , Ashley Montanaro

The Quantum Approximate Optimization Algorithm, QAOA, uses a shallow depth quantum circuit to produce a parameter dependent state. For a given combinatorial optimization problem instance, the quantum expectation of the associated cost…

Quantum Physics · Physics 2018-12-12 Fernando G. S. L. Brandao , Michael Broughton , Edward Farhi , Sam Gutmann , Hartmut Neven

The quantum approximate optimization algorithm (QAOA) transforms a simple many-qubit wavefunction into one which encodes a solution to a difficult classical optimization problem. It does this by optimizing the schedule according to which…

Quantum Physics · Physics 2022-06-29 Yunlong Yu , Chenfeng Cao , Carter Dewey , Xiang-Bin Wang , Nic Shannon , Robert Joynt

A frequent starting point of quantum computation platforms are two-state quantum systems, i.e., qubits. However, in the context of integer optimization problems, relevant to scheduling optimization and operations research, it is often more…

The Quantum Approximate Optimization Algorithm (QAOA) is a powerful tool in solving various combinatorial problems such as Maximum Satisfiability and Maximum Cut. Hard computational problems, however, require deep circuits that place high…

Quantum Physics · Physics 2025-10-28 Malick A. Gaye , Omar Shehab , Paraj Titum , Gregory Quiroz