English
Related papers

Related papers: Molecule Generation with Fragment Retrieval Augmen…

200 papers

Retrieval-Augmented Generation (RAG) aims to generate more reliable and accurate responses, by augmenting large language models (LLMs) with the external vast and dynamic knowledge. Most previous work focuses on using RAG for single-round…

Artificial Intelligence · Computer Science 2024-03-28 Linhao Ye , Zhikai Lei , Jianghao Yin , Qin Chen , Jie Zhou , Liang He

We introduce AccurateRAG -- a novel framework for constructing high-performance question-answering applications based on retrieval-augmented generation (RAG). Our framework offers a pipeline for development efficiency with tools for raw…

Computation and Language · Computer Science 2026-03-04 Linh The Nguyen , Chi Tran , Dung Ngoc Nguyen , Van-Cuong Pham , Hoang Ngo , Dat Quoc Nguyen

Retrieval-Augmented Generation (RAG) methods enhance LLM performance by efficiently filtering relevant context for LLMs, reducing hallucinations and inference cost. However, most existing RAG methods focus on single-step retrieval, which is…

Large language models (LLMs) often need to incorporate external knowledge to solve theme-specific problems. Retrieval-augmented generation (RAG) has shown its high promise, empowering LLMs to generate more qualified responses with retrieved…

Machine Learning · Computer Science 2025-08-05 Jimeng Shi , Sizhe Zhou , Bowen Jin , Wei Hu , Runchu Tian , Shaowen Wang , Giri Narasimhan , Jiawei Han

Recent advances in graph learning have paved the way for innovative retrieval-augmented generation (RAG) systems that leverage the inherent relational structures in graph data. However, many existing approaches suffer from rigid, fixed…

Information Retrieval · Computer Science 2025-03-26 Yuan Li , Jun Hu , Jiaxin Jiang , Zemin Liu , Bryan Hooi , Bingsheng He

While human cognition inherently retrieves information from diverse and specialized knowledge sources during decision-making processes, current Retrieval-Augmented Generation (RAG) systems typically operate through single-source knowledge…

Machine Learning · Computer Science 2025-03-19 Zhengsheng Guo , Linwei Zheng , Xinyang Chen , Xuefeng Bai , Kehai Chen , Min Zhang

Recent advancements in generative models have established state-of-the-art benchmarks in the generation of molecules and novel drug candidates. Despite these successes, a significant gap persists between generative models and the…

Machine Learning · Computer Science 2024-10-10 Aditya Malusare , Vaneet Aggarwal

Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

The ability to form, retrieve, and reason about memories in response to stimuli serves as the cornerstone for general intelligence - shaping entities capable of learning, adaptation, and intuitive insight. Large Language Models (LLMs) have…

Computation and Language · Computer Science 2024-09-25 Brendan Hogan Rappazzo , Yingheng Wang , Aaron Ferber , Carla Gomes

Molecule generation using generative AI is vital for drug discovery, yet class-specific datasets often contain fewer than 100 training examples. While fragment-based models handle limited data better than atom-based approaches, existing…

Artificial Intelligence · Computer Science 2025-11-27 Yuto Suzuki , Paul Awolade , Daniel V. LaBarbera , Farnoush Banaei-Kashani

Drug discovery is a complex process that involves multiple stages and tasks. However, existing molecular generative models can only tackle some of these tasks. We present Generalist Molecular generative model (GenMol), a versatile framework…

Machine Learning · Computer Science 2025-07-24 Seul Lee , Karsten Kreis , Srimukh Prasad Veccham , Meng Liu , Danny Reidenbach , Yuxing Peng , Saee Paliwal , Weili Nie , Arash Vahdat

We introduce a novel retrieval-augmented generation (RAG) framework tailored for multihop question answering. First, our system uses large language model (LLM) to decompose complex multihop questions into a sequence of single-hop…

Computation and Language · Computer Science 2025-08-14 Seokgi Lee

Retrieval-augmented generation (RAG) synergizes the retrieval of pertinent data with the generative capabilities of Large Language Models (LLMs), ensuring that the generated output is not only contextually relevant but also accurate and…

Retrieval Augmented Generation (RAG) is a promising technique for mitigating two key limitations of large language models (LLMs): outdated information and hallucinations. RAG system stores documents as embedding vectors in a database. Given…

Information Retrieval · Computer Science 2026-02-10 Taehee Jeong , Xingzhe Zhao , Peizu Li , Markus Valvur , Weihua Zhao

This paper presents Loops On Retrieval Augmented Generation (LoRAG), a new framework designed to enhance the quality of retrieval-augmented text generation through the incorporation of an iterative loop mechanism. The architecture…

Computation and Language · Computer Science 2024-03-26 Ayush Thakur , Rashmi Vashisth

This work presents a Biomedical Literature Question Answering (Q&A) system based on a Retrieval-Augmented Generation (RAG) architecture, designed to improve access to accurate, evidence-based medical information. Addressing the shortcomings…

Computation and Language · Computer Science 2025-09-09 Mansi Garg , Lee-Chi Wang , Bhavesh Ghanchi , Sanjana Dumpala , Shreyash Kakde , Yen Chih Chen

Existing multimodal Retrieval-Augmented Generation (RAG) methods for visually rich documents (VRD) are often biased towards retrieving salient knowledge(e.g., prominent text and visual elements), while largely neglecting the critical…

Information Retrieval · Computer Science 2025-11-26 Anyang Tong , Xiang Niu , ZhiPing Liu , Chang Tian , Yanyan Wei , Zenglin Shi , Meng Wang

Retrieval-augmented generation (RAG) is key to enhancing large language models (LLMs) to systematically access richer factual knowledge. Yet, using RAG brings intrinsic challenges, as LLMs must deal with potentially conflicting knowledge,…

Computation and Language · Computer Science 2025-04-08 Leonardo Ranaldi , Federico Ranaldi , Fabio Massimo Zanzotto , Barry Haddow , Alexandra Birch

Retrieval-Augmented Generation (RAG) improves large language models (LLMs) by retrieving relevant information from external sources and has been widely adopted for text-based tasks. For structured data, such as knowledge graphs, Graph…

Information Retrieval · Computer Science 2026-03-05 Haoyu Han , Li Ma , Yu Wang , Harry Shomer , Yongjia Lei , Zhisheng Qi , Kai Guo , Zhigang Hua , Bo Long , Hui Liu , Charu C. Aggarwal , Jiliang Tang

Recently, Retrieval Augmented Generation (RAG) has emerged as a powerful technique in natural language processing, combining the strengths of retrieval-based and generation-based models to enhance text generation tasks. However, the…

Computation and Language · Computer Science 2024-08-15 Samhaa R. El-Beltagy , Mohamed A. Abdallah