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Recently, text-to-molecule models have shown great potential across various chemical applications, e.g., drug-discovery. These models adapt language models to molecular data by representing molecules as sequences of atoms. However, they…

Computation and Language · Computer Science 2025-09-18 Seojin Kim , Hyeontae Song , Jaehyun Nam , Jinwoo Shin

Molecular property prediction aims to learn representations that map chemical structures to functional properties. While multimodal learning has emerged as a powerful paradigm to learn molecular representations, prior works have largely…

Machine Learning · Computer Science 2026-03-03 Feng Jiang , Mangal Prakash , Hehuan Ma , Jianyuan Deng , Yuzhi Guo , Amina Mollaysa , Tommaso Mansi , Rui Liao , Junzhou Huang

Graph generation techniques are increasingly being adopted for drug discovery. Previous graph generation approaches have utilized relatively small molecular building blocks such as atoms or simple cycles, limiting their effectiveness to…

Machine Learning · Computer Science 2020-04-21 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Long-context multiple-choice question answering tasks require robust reasoning over extensive text sources. Since most of the pre-trained transformer models are restricted to processing only a few hundred words at a time, successful…

Information Retrieval · Computer Science 2025-01-28 Manish Singh , Manish Shrivastava

Large language models have made significant strides in natural language processing, enabling innovative applications in molecular science by processing textual representations of molecules. However, most existing language models cannot…

Machine Learning · Computer Science 2024-02-07 Pengfei Liu , Yiming Ren , Jun Tao , Zhixiang Ren

Text image machine translation (TIMT) aims to translate texts embedded in images from one source language to another target language. Existing methods, both two-stage cascade and one-stage end-to-end architectures, suffer from different…

Computation and Language · Computer Science 2023-05-11 Cong Ma , Yaping Zhang , Mei Tu , Yang Zhao , Yu Zhou , Chengqing Zong

Coordinating multiple agents to collaboratively maximize submodular functions in unpredictable environments is a critical task with numerous applications in machine learning, robot planning and control. The existing approaches, such as the…

Multiagent Systems · Computer Science 2025-02-10 Qixin Zhang , Zongqi Wan , Yu Yang , Li Shen , Dacheng Tao

Flow Matching (FM) generative models offer efficient simulation-free training and deterministic sampling, but their practical deployment is challenged by high-precision parameter requirements. We adapt optimal transport (OT)-based…

Machine Learning · Computer Science 2025-11-17 Dara Varam , Diaa A. Abuhani , Imran Zualkernan , Raghad AlDamani , Lujain Khalil

Merging models fine-tuned for different tasks into a single unified model has become an increasingly important direction for building versatile, efficient multi-task systems. Existing approaches predominantly rely on parameter interpolation…

Machine Learning · Computer Science 2025-11-26 Zecheng Pan , Zhikang Chen , Ding Li , Min Zhang , Sen Cui , Hongshuo Jin , Luqi Tao , Yi Yang , Deheng Ye , Yu Zhang , Tingting Zhu , Tianling Ren

The integration of molecular and natural language representations has emerged as a focal point in molecular science, with recent advancements in Language Models (LMs) demonstrating significant potential for comprehensive modeling of both…

Biomolecules · Quantitative Biology 2025-03-19 Qizhi Pei , Rui Yan , Kaiyuan Gao , Jinhua Zhu , Lijun Wu

We study the use of amortized optimization to predict optimal transport (OT) maps from the input measures, which we call Meta OT. This helps repeatedly solve similar OT problems between different measures by leveraging the knowledge and…

Machine Learning · Computer Science 2023-06-06 Brandon Amos , Samuel Cohen , Giulia Luise , Ievgen Redko

We introduce G2T-LLM, a novel approach for molecule generation that uses graph-to-tree text encoding to transform graph-based molecular structures into a hierarchical text format optimized for large language models (LLMs). This encoding…

Machine Learning · Computer Science 2024-10-04 Zhaoning Yu , Xiangyang Xu , Hongyang Gao

Like many scientific fields, new chemistry literature has grown at a staggering pace, with thousands of papers released every month. A large portion of chemistry literature focuses on new molecules and reactions between molecules. Most…

Quantitative Methods · Quantitative Biology 2021-09-10 Daniel Campos , Heng Ji

Virtual cell modeling predicts molecular state changes under genetic perturbations in silico, which is essential for biological mechanism studies. However, existing approaches suffer from unconstrained reasoning, uninterpretable…

Quantitative Methods · Quantitative Biology 2026-04-23 Zhenyu Wang , Geyan Ye , Wei Liu , Man Tat Alexander Ng

Cross-lingual or cross-domain correspondences play key roles in tasks ranging from machine translation to transfer learning. Recently, purely unsupervised methods operating on monolingual embeddings have become effective alignment tools.…

Computation and Language · Computer Science 2018-09-05 David Alvarez-Melis , Tommi S. Jaakkola

Molecular dynamics (MD) simulations underpin modern computational drug discovery, materials science, and biochemistry. Recent machine learning models provide high-fidelity MD predictions without the need to repeatedly solve quantum…

Machine Learning · Computer Science 2026-04-24 Luke Thompson , Davy Guan , Dai Shi , Slade Matthews , Junbin Gao , Andi Han

Recent advances in label assignment in object detection mainly seek to independently define positive/negative training samples for each ground-truth (gt) object. In this paper, we innovatively revisit the label assignment from a global…

Computer Vision and Pattern Recognition · Computer Science 2021-03-29 Zheng Ge , Songtao Liu , Zeming Li , Osamu Yoshie , Jian Sun

We address the problem of learning on sets of features, motivated by the need of performing pooling operations in long biological sequences of varying sizes, with long-range dependencies, and possibly few labeled data. To address this…

Machine Learning · Computer Science 2021-02-11 Grégoire Mialon , Dexiong Chen , Alexandre d'Aspremont , Julien Mairal

Optical Chemical Structure Recognition (OCSR) is essential for converting molecular images into machine-readable formats. While recent vision-language models (VLMs) have shown promise, their image-captioning approach often struggles with…

Artificial Intelligence · Computer Science 2026-01-14 Jingchao Wang , Yifan He , Haote Yang , Jiang Wu , Lingli Ge , Xingjian Wei , Yinfan Wang , Linye Li , Huijie Ao , Chengjin Liu , Bin Wang , Lijun Wu , Conghui He

Generating text from graph-based data, such as Abstract Meaning Representation (AMR), is a challenging task due to the inherent difficulty in how to properly encode the structure of a graph with labeled edges. To address this difficulty, we…

Computation and Language · Computer Science 2019-09-04 Leonardo F. R. Ribeiro , Claire Gardent , Iryna Gurevych
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