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Rapid advancements in genome sequencing have led to the collection of vast amounts of genomics data. Researchers may be interested in using machine learning models on such data to predict the pathogenicity or clinical significance of a…

Quantitative Methods · Quantitative Biology 2024-08-15 Arshmeet Kaur , Morteza Sarmadi

Background: Researchers typically identify pregnancies in healthcare data based on observed outcomes (e.g., delivery). This outcome-based approach misses pregnancies that received prenatal care but whose outcomes were not recorded (e.g.,…

Linear Mixed Models (LMMs) are important tools in statistical genetics. When used for feature selection, they allow to find a sparse set of genetic traits that best predict a continuous phenotype of interest, while simultaneously correcting…

In some supervised learning settings, the practitioner might have additional information on the features used for prediction. We propose a new method which leverages this additional information for better prediction. The method, which we…

Methodology · Statistics 2020-06-03 J. Kenneth Tay , Nima Aghaeepour , Trevor Hastie , Robert Tibshirani

In the social sciences, it is often necessary to debias studies and surveys before valid conclusions can be drawn. Debiasing algorithms enable the computational removal of bias using sample weights. However, an issue arises when only a…

Machine Learning · Computer Science 2026-03-03 Tony Hauptmann , Stefan Kramer

Linear discriminant analysis is a widely used method for classification. However, the high dimensionality of predictors combined with small sample sizes often results in large classification errors. To address this challenge, it is crucial…

Machine Learning · Statistics 2025-01-09 Hongzhe Zhang , Arnab Auddy , Hongzhe Lee

We present a novel adaptive random subspace learning algorithm (RSSL) for prediction purpose. This new framework is flexible where it can be adapted with any learning technique. In this paper, we tested the algorithm for regression and…

Machine Learning · Computer Science 2015-02-10 Mohamed Elshrif , Ernest Fokoue

Parent selection plays an important role in evolutionary algorithms, and many strategies exist to select the parent pool before breeding the next generation. Methods often rely on average error over the entire dataset as a criterion to…

Neural and Evolutionary Computing · Computer Science 2024-04-12 Guilherme Seidyo Imai Aldeia , Fabricio Olivetti de Franca , William G. La Cava

Feature selection, as a critical pre-processing step for machine learning, aims at determining representative predictors from a high-dimensional feature space dataset to improve the prediction accuracy. However, the increase in feature…

Machine Learning · Statistics 2020-11-16 Fatemeh Amini , Guiping Hu

This paper studies the high-dimensional mixed linear regression (MLR) where the output variable comes from one of the two linear regression models with an unknown mixing proportion and an unknown covariance structure of the random…

Methodology · Statistics 2020-11-10 Linjun Zhang , Rong Ma , T. Tony Cai , Hongzhe Li

Data labeling is currently a time-consuming task that often requires expert knowledge. In research settings, the availability of correctly labeled data is crucial to ensure that model predictions are accurate and useful. We propose…

Machine Learning · Computer Science 2018-12-31 Marina Bendersky , Joy Wu , Tanveer Syeda-Mahmood

Model averaging is an alternative to model selection for dealing with model uncertainty, which is widely used and very valuable. However, most of the existing model averaging methods are proposed based on the least squares loss function,…

Methodology · Statistics 2019-10-29 Miaomiao Wang , Guohua Zou

In a linear regression model with random design, we consider a family of candidate models from which we want to select a `good' model for prediction out-of-sample. We fit the models using block shrinkage estimators, and we focus on the…

Statistics Theory · Mathematics 2018-09-13 Hannes Leeb , Nina Senitschnig

In this paper, we introduce a novel high-dimensional Factor-Adjusted sparse Partially Linear regression Model (FAPLM), to integrate the linear effects of high-dimensional latent factors with the nonparametric effects of low-dimensional…

Methodology · Statistics 2025-01-14 Yanmei Shi , Meiling Hao , Yanlin Tang , Xu Guo

Data-driven model discovery (DDMD) algorithms are powerful tools for extracting interpretable symbolic models from data. However, identifying the model that best balances goodness-of-fit and sparsity is often a laborious process requiring…

Quantitative Methods · Quantitative Biology 2026-02-26 Michael C Chung , Alen Zacharia , Juan Guan

Fetal growth restriction (FGR) is a prevalent pregnancy condition characterised by failure of the fetus to reach its genetically predetermined growth potential. We explore the application of model fitting techniques, linear regression…

Owing to the advantages of increased accuracy and the potential to detect unseen patterns, provided by data mining techniques they have been widely incorporated for standard classification problems. They have often been used for high…

Machine Learning · Computer Science 2022-10-05 Anirudha Rayasam , Nagamma Patil

We explore whether survival model performance in underrepresented high- and low-risk subgroups - regions of the prognostic spectrum where clinical decisions are most consequential - can be improved through targeted restructuring of the…

Background: Reporting and Data Systems (RADS) standardize radiology risk communication but automated RADS assignment from narrative reports is challenging because of guideline complexity, output-format constraints, and limited benchmarking…

Genetic algorithms are a widely used method in chemometrics for extracting variable subsets with high prediction power. Most fitness measures used by these genetic algorithms are based on the ordinary least-squares fit of the resulting…

Computation · Statistics 2017-11-21 David Kepplinger , Peter Filzmoser , Kurt Varmuza
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