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Spatial transcriptomics aims to connect high-resolution histology images with spatially resolved gene expression. To achieve better performance on downstream tasks such as gene expression prediction, large-scale pre-training is required to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Jiahe Qian , Yaoyu Fang , Ziqiao Weng , Xinkun Wang , Lee A. Cooper , Bo Zhou

The integration of molecular and natural language representations has emerged as a focal point in molecular science, with recent advancements in Language Models (LMs) demonstrating significant potential for comprehensive modeling of both…

Biomolecules · Quantitative Biology 2025-03-19 Qizhi Pei , Rui Yan , Kaiyuan Gao , Jinhua Zhu , Lijun Wu

Urban region profiling from web-sourced data is of utmost importance for urban planning and sustainable development. We are witnessing a rising trend of LLMs for various fields, especially dealing with multi-modal data research such as…

Computation and Language · Computer Science 2024-03-26 Yibo Yan , Haomin Wen , Siru Zhong , Wei Chen , Haodong Chen , Qingsong Wen , Roger Zimmermann , Yuxuan Liang

The Contrastive Language-Image Pretraining (CLIP) model has significantly advanced vision-language modeling by aligning image-text pairs from large-scale web data through self-supervised contrastive learning. Yet, its reliance on uncurated…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Xin Yao , Haiyang Zhao , Yimin Chen , Jiawei Guo , Kecheng Huang , Ming Zhao

Visual Geo-localization (VG) refers to the process to identify the location described in query images, which is widely applied in robotics field and computer vision tasks, such as autonomous driving, metaverse, augmented reality, and SLAM.…

Computer Vision and Pattern Recognition · Computer Science 2024-06-05 Chen Mao , Jingqi Hu

Molecular modeling, a central topic in quantum mechanics, aims to accurately calculate the properties and simulate the behaviors of molecular systems. The molecular model is governed by physical laws, which impose geometric constraints such…

Machine Learning · Computer Science 2024-06-25 Tianlang Chen , Shengjie Luo , Di He , Shuxin Zheng , Tie-Yan Liu , Liwei Wang

Multi-camera 3D object detection for autonomous driving is a challenging problem that has garnered notable attention from both academia and industry. An obstacle encountered in vision-based techniques involves the precise extraction of…

Computer Vision and Pattern Recognition · Computer Science 2023-04-10 Linyan Huang , Huijie Wang , Jia Zeng , Shengchuan Zhang , Liujuan Cao , Junchi Yan , Hongyang Li

Contrastive Language-Image Pre-training (CLIP) has drawn increasing attention recently for its transferable visual representation learning. However, due to the semantic gap within datasets, CLIP's pre-trained image-text alignment becomes…

Computer Vision and Pattern Recognition · Computer Science 2023-08-11 Longtian Qiu , Renrui Zhang , Ziyu Guo , Ziyao Zeng , Zilu Guo , Yafeng Li , Guangnan Zhang

Contrastive Language-Image Pre-training (CLIP) has demonstrated strong generalization across a wide range of visual tasks by leveraging large-scale English-image pairs. However, its extension to low-resource languages remains limited due to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Dahyun Chung , Donghyun Shin , Yujin Sung , Seunggi Moon , Jinwoo Jeon , Byung-Jun Lee

Text-to-shape retrieval is an increasingly relevant problem with the growth of 3D shape data. Recent work on contrastive losses for learning joint embeddings over multimodal data has been successful at tasks such as retrieval and…

Computer Vision and Pattern Recognition · Computer Science 2023-12-29 Yue Ruan , Han-Hung Lee , Yiming Zhang , Ke Zhang , Angel X. Chang

The preservation of aquatic biodiversity is critical in mitigating the effects of climate change. Aquatic scene understanding plays a pivotal role in aiding marine scientists in their decision-making processes. In this paper, we introduce…

Computer Vision and Pattern Recognition · Computer Science 2025-02-05 Basit Alawode , Iyyakutti Iyappan Ganapathi , Sajid Javed , Naoufel Werghi , Mohammed Bennamoun , Arif Mahmood

We propose a novel framework for ID-preserving generation using a multi-modal encoding strategy rather than injecting identity features via adapters into pre-trained models. Our method treats identity and text as a unified conditioning…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Zichuan Liu , Liming Jiang , Qing Yan , Yumin Jia , Hao Kang , Xin Lu

Geometry problem-solving remains a significant challenge for Large Multimodal Models (LMMs), requiring not only global shape recognition but also attention to intricate local relationships related to geometric theory. To address this, we…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Linger Deng , Yuliang Liu , Wenwen Yu , Zujia Zhang , Jianzhong Ju , Zhenbo Luo , Xiang Bai

Molecular Machine Learning (ML) bears promise for efficient molecule property prediction and drug discovery. However, labeled molecule data can be expensive and time-consuming to acquire. Due to the limited labeled data, it is a great…

Machine Learning · Computer Science 2022-04-01 Yuyang Wang , Jianren Wang , Zhonglin Cao , Amir Barati Farimani

Ground-state 3D geometries of molecules are essential for many molecular analysis tasks. Modern quantum mechanical methods can compute accurate 3D geometries but are computationally prohibitive. Currently, an efficient alternative to…

Chemical Physics · Physics 2023-05-24 Zhao Xu , Yaochen Xie , Youzhi Luo , Xuan Zhang , Xinyi Xu , Meng Liu , Kaleb Dickerson , Cheng Deng , Maho Nakata , Shuiwang Ji

Vision-Language models like CLIP have been widely adopted for various tasks due to their impressive zero-shot capabilities. However, CLIP is not suitable for extracting 3D geometric features as it was trained on only images and text by…

Computer Vision and Pattern Recognition · Computer Science 2023-04-20 Deepti Hegde , Jeya Maria Jose Valanarasu , Vishal M. Patel

Vision-language foundation models, represented by Contrastive Language-Image Pre-training (CLIP), have gained increasing attention for jointly understanding both vision and textual tasks. However, existing approaches primarily focus on…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Bowen Shi , Peisen Zhao , Zichen Wang , Yuhang Zhang , Yaoming Wang , Jin Li , Wenrui Dai , Junni Zou , Hongkai Xiong , Qi Tian , Xiaopeng Zhang

Graph neural networks are emerging as promising methods for modeling molecular graphs, in which nodes and edges correspond to atoms and chemical bonds, respectively. Recent studies show that when 3D molecular geometries, such as bond…

Machine Learning · Computer Science 2021-10-06 Zhao Xu , Youzhi Luo , Xuan Zhang , Xinyi Xu , Yaochen Xie , Meng Liu , Kaleb Dickerson , Cheng Deng , Maho Nakata , Shuiwang Ji

Multimodal geometry reasoning requires models to jointly understand visual diagrams and perform structured symbolic inference, yet current vision--language models struggle with complex geometric constructions due to limited training data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Haobo Lin , Tianyi Bai , Chen Chen , Jiajun Zhang , Bohan Zeng , Wentao Zhang , Binhang Yuan

Structure-based drug design aims at generating high affinity ligands with prior knowledge of 3D target structures. Existing methods either use conditional generative model to learn the distribution of 3D ligands given target binding sites,…

Biomolecules · Quantitative Biology 2024-03-18 Yuwei Yang , Siqi Ouyang , Xueyu Hu , Mingyue Zheng , Hao Zhou , Lei Li