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Continuous glucose monitoring (CGM) provides dense and dynamic glucose profiles that enable reliable estimation of Ambulatory Glucose Profile (AGP) metrics, such as Time in Range (TIR), Time Below Range (TBR), and Time Above Range (TAR).…

Machine Learning · Computer Science 2025-10-09 Canyu Lei , Benjamin Lobo , Jianxin Xie

The growing worldwide incidence of diabetes requires more effective approaches for managing blood glucose levels. Insulin delivery systems have advanced significantly, with artificial intelligence (AI) playing a key role in improving their…

Artificial Intelligence · Computer Science 2025-03-25 Maria Panagiotou , Knut Stroemmen , Lorenzo Brigato , Bastiaan E. de Galan , Stavroula Mougiakakou

Precise glucose level monitoring is critical for people with diabetes to avoid serious complications. While there are several methods for continuous glucose level monitoring, research on maintenance devices is limited. To mitigate the gap,…

Machine Learning · Computer Science 2024-06-10 Azmine Toushik Wasi

Calculating mealtime insulin doses poses a significant challenge for individuals with Type 1 Diabetes (T1D). Doses should perfectly compensate for expected post-meal glucose excursions, requiring a profound understanding of the individual's…

Quantitative Methods · Quantitative Biology 2024-06-24 Anas El Fathi , Elliott Pryor , Marc D. Breton

Medical Cyber-physical Systems (MCPS) are vulnerable to accidental or malicious faults that can target their controllers and cause safety hazards and harm to patients. This paper proposes a combined model and data-driven approach for…

Artificial Intelligence · Computer Science 2021-04-14 Xugui Zhou , Bulbul Ahmed , James H. Aylor , Philip Asare , Homa Alemzadeh

A task of vital clinical importance, within Diabetes management, is the prevention of hypo/hyperglycemic events. Increasingly adopted Continuous Glucose Monitoring (CGM) devices offer detailed, non-intrusive and real time insights into a…

Machine Learning · Computer Science 2023-03-09 Jakub J. Dylag

Pancreatic \b{eta}-cells secrete insulin in response to blood sugar levels to maintain glucose homeostasis. This vital insulin exocytosis is controlled by the cell's bursting behaviours, which are regulated by tight bidirectional coupling…

Dynamical Systems · Mathematics 2026-03-03 Prannath Moolchand , Martin Wechselberger

This paper investigates the design of self-triggered controllers for networked control systems (NCSs), where the dynamics of the plant is \textit{unknown} apriori. To deal with the unknown transition dynamics, we employ the Gaussian process…

Systems and Control · Electrical Eng. & Systems 2020-03-10 Kazumune Hashimoto , Yuichi Yoshimura , Toshimitsu Ushio

Most control systems run on digital hardware with limited communication resources. This work develops self-triggered control for linear systems where sensors update independently (asynchronous measurements). The controller computes an…

Systems and Control · Electrical Eng. & Systems 2025-11-21 Abbas Tariverdi

With continuous glucose monitoring (CGM), data-driven models on blood glucose prediction have been shown to be effective in related work. However, such (CGM) systems are not always available, e.g., for a patient at home. In this work, we…

Computers and Society · Computer Science 2024-04-10 Tu Nguyen , Markus Rokicki

In this paper, we present a model-based periodic event-triggered control mechanism for nonlinear continuous-time Networked Control Systems. A sampled-data prediction of the system behavior is used at the actuator to reduce the amount of…

Systems and Control · Electrical Eng. & Systems 2020-02-03 Michael Hertneck , Steffen Linsenmayer , Frank Allgöwer

This paper investigates the design of self-triggered control for networked control systems (NCS), where the dynamics of the plant is unknown apriori. To deal with the nature of the self-triggered control, in which state measurements are…

Systems and Control · Electrical Eng. & Systems 2022-02-22 Wang Zhijun , Kazumune Hashimoto , Wataru Hashimoto , Shigemasa Takai

The rapid evolution of Cyber-Physical Systems (CPS) across various domains like mobility systems, networked control systems, sustainable manufacturing, smart power grids, and the Internet of Things necessitates innovative solutions that…

Optimization and Control · Mathematics 2024-06-25 Andreas A. Malikopoulos

The highly fluctuated renewable generations and electric vehicles have undergone tremendous growth in recent years. The majority of them are connected to the grid via power electronic devices, resulting in wide variation ranges for several…

Systems and Control · Electrical Eng. & Systems 2021-08-13 Likai Liu , Zechun Hu , Asad Mujeeb

High quality real world datasets are essential for advancing data driven approaches in type 1 diabetes (T1D) management, including personalized therapy design, digital twin systems, and glucose prediction models. However, progress in this…

Machine Learning · Computer Science 2025-06-19 Saman Khamesian , Asiful Arefeen , Bithika M. Thompson , Maria Adela Grando , Hassan Ghasemzadeh

In this paper, we propose a self-triggered formulation of Model Predictive Control for continuous-time nonlinear input-affine networked control systems. Our control method specifies not only when to execute control tasks but also provides a…

Optimization and Control · Mathematics 2016-11-17 Kazumune Hashimoto , Shuichi Adachi , Dimos. V. Dimarogonas

This paper presents the Adaptive Personalized Control System (APECS) architecture, a novel framework for human-in-the-loop control. An architecture is developed which defines appropriate constraints for the system objectives. A method for…

Systems and Control · Electrical Eng. & Systems 2025-03-14 Marius F. R. Juston , Alex Gisi , William R. Norris , Dustin Nottage , Ahmet Soylemezoglu

This paper considers self-triggered consensus control of unknown linear multi-agent systems (MASs). Self-triggering mechanisms (STMs) are widely used in MASs, thanks to their advantages in avoiding continuous monitoring and saving computing…

Systems and Control · Electrical Eng. & Systems 2023-10-20 Yifei Li , Xin Wang , Jian Sun , Gang Wang , Jie Chen

We present GlucOS, a novel system for trustworthy automated insulin delivery. Fundamentally, this paper is about a system we designed, implemented, and deployed on real humans and the lessons learned from our experiences. GlucOS introduces…

Cryptography and Security · Computer Science 2025-10-28 Hari Venugopalan , Shreyas Madhav Ambattur Vijayanand , Caleb Stanford , Stephanie Crossen , Samuel T. King

In networked control systems, communication is a shared and therefore scarce resource. Event-triggered control (ETC) can achieve high performance control with a significantly reduced amount of samples compared to classical, periodic control…

Systems and Control · Computer Science 2019-03-20 Dominik Baumann , Friedrich Solowjow , Karl Henrik Johansson , Sebastian Trimpe