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Mendelian randomization is an instrumental variable method that utilizes genetic information to investigate the causal effect of a modifiable exposure on an outcome. In most cases, the exposure changes over time. Understanding the…

Methodology · Statistics 2024-03-11 Haodong Tian , Ashish Patel , Stephen Burgess

We study the identifiability of parameters and falsifiability of predictions under the process of model expansion in a Bayesian setting. Identifiability is represented by the closeness of the posterior to the prior distribution and…

Statistics Theory · Mathematics 2025-10-15 Collin Cademartori

We derive multiscale statistics for deconvolution in order to detect qualitative features of the unknown density. An important example covered within this framework is to test for local monotonicity on all scales simultaneously. We…

Statistics Theory · Mathematics 2015-03-19 Johannes Schmidt-Hieber , Axel Munk , Lutz Duembgen

Airborne particulate matter (PM2.5) is a major public health concern in urban environments, where population density and emission sources exacerbate exposure risks. We present a novel Bayesian spatiotemporal fusion model to estimate monthly…

We study adaptive querying for learning user-dependent quantities of interest, such as responses to held-out items and psychometric indicators, within tight question budgets. Classical Bayesian design and computerized adaptive testing…

Machine Learning · Statistics 2026-05-04 Kaizheng Wang , Yuhang Wu , Assaf Zeevi

Although tissues are usually studied in isolation, this situation rarely occurs in biology, as cells, tissues, and organs, coexist and interact across scales to determine both shape and function. Here, we take a quantitative approach…

Tissues and Organs · Quantitative Biology 2023-02-07 Carles Falcó , Daniel J. Cohen , José A. Carrillo , Ruth E. Baker

As we gain access to a greater depth and range of health-related information about individuals, three questions arise: (1) Can we build better models to predict individual-level risk of ill health? (2) How much data do we need to…

Machine Learning · Statistics 2021-04-27 Mark Green

We develop a Gaussian process ("GP") framework for modeling mortality rates and mortality improvement factors. GP regression is a nonparametric, data-driven approach for determining the spatial dependence in mortality rates and jointly…

Methodology · Statistics 2018-04-13 Mike Ludkovski , Jimmy Risk , Howard Zail

Personalized image generation, where reference images of one or more subjects are used to generate their image according to a scene description, has gathered significant interest in the community. However, such generated images suffer from…

Computer Vision and Pattern Recognition · Computer Science 2025-07-23 Parul Gupta , Abhinav Dhall , Thanh-Toan Do

Data-informed predictive maintenance planning largely relies on stochastic deterioration models. Monitoring information can be utilized to update sequentially the knowledge on time-invariant deterioration model parameters either within an…

Computation · Statistics 2023-08-02 Antonios Kamariotis , Luca Sardi , Iason Papaioannou , Eleni Chatzi , Daniel Straub

Bayesian methods are appealing in their flexibility in modeling complex data and ability in capturing uncertainty in parameters. However, when Bayes' rule does not result in tractable closed-form, most approximate inference algorithms lack…

Machine Learning · Computer Science 2016-05-09 Bo Dai , Niao He , Hanjun Dai , Le Song

The explosion in high-resolution data capture technologies in health has increased interest in making inferences about individual-level parameters. While technology may provide substantial data on a single individual, how best to use…

Methodology · Statistics 2021-12-16 Ziyu Ji , Julian Wolfson

Decomposition has become an increasingly popular technique for evolutionary multi-objective optimization (EMO). A decomposition-based EMO algorithm is usually designed to approximate a whole Pareto-optimal front (PF). However, in practice,…

Neural and Evolutionary Computing · Computer Science 2018-10-02 Ke Li , Renzhi Chen , Dragan Savic , Xin Yao

Distributed lag models are useful in environmental epidemiology as they allow the user to investigate critical windows of exposure, defined as the time period during which exposure to a pollutant adversely affects health outcomes. Recent…

Methodology · Statistics 2021-08-02 Joseph Antonelli , Ander Wilson , Brent Coull

Computer experiments are becoming increasingly important in scientific investigations. In the presence of uncertainty, analysts employ probabilistic sensitivity methods to identify the key-drivers of change in the quantities of interest.…

Methodology · Statistics 2024-07-02 Isadora Antoniano-Villalobos , Emanuele Borgonovo , Xuefei Lu

Given an image of a natural scene, we are able to quickly decompose it into a set of components such as objects, lighting, shadows, and foreground. We can then envision a scene where we combine certain components with those from other…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Jocelin Su , Nan Liu , Yanbo Wang , Joshua B. Tenenbaum , Yilun Du

Current theories of perception suggest that the brain represents features of the world as probability distributions, but can such uncertain foundations provide the basis for everyday vision? Perceiving objects and scenes requires knowing…

Neurons and Cognition · Quantitative Biology 2022-11-30 Andrey Chetverikov , Árni Kristjánsson

Population dynamics models play an important role in a number of fields, such as actuarial science, demography, and ecology, as they help explain past fluctuations and predict future population. The accuracy of these models is often…

Methodology · Statistics 2025-11-06 Paolo Onorati , Sofia Ruiz-Suarez , Radu Craiu

Stochastic reduced models are an important tool in climate systems whose many spatial and temporal scales cannot be fully discretized or underlying physics may not be fully accounted for. One form of reduced model, the linear inverse model…

Methodology · Statistics 2020-04-29 Dallas Foster , Darin Comeau , Nathan M. Urban

Recent research has proven neural networks to be a powerful tool for performing hyperspectral imaging (HSI) target identification. However, many deep learning frameworks deliver a single material class prediction and operate on a per-pixel…

Machine Learning · Computer Science 2025-08-14 Joshua R. Tempelman , Kevin Mitchell , Adam J. Wachtor , Eric B. Flynn