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Large Language Models (LLMs) are increasingly deployed for clinical reasoning tasks, which inherently require eliciting calibrated probabilistic beliefs based on available evidence. However, real-world clinical data are frequently…

Artificial Intelligence · Computer Science 2026-03-19 Yuta Kobayashi , Vincent Jeanselme , Shalmali Joshi

Combining multiple modalities carrying complementary information through multimodal learning (MML) has shown considerable benefits for diagnosing multiple pathologies. However, the robustness of multimodal models to missing modalities is…

Machine Learning · Computer Science 2024-07-31 Hava Chaptoukaev , Vincenzo Marcianó , Francesco Galati , Maria A. Zuluaga

Missing values exist in nearly all clinical studies because data for a variable or question are not collected or not available. Inadequate handling of missing values can lead to biased results and loss of statistical power in analysis.…

Machine Learning · Computer Science 2021-03-04 Narges Pourshahrokhi , Samaneh Kouchaki , Kord M. Kober , Christine Miaskowski , Payam Barnaghi

This paper contributes with a pragmatic evaluation framework for explainable Machine Learning (ML) models for clinical decision support. The study revealed a more nuanced role for ML explanation models, when these are pragmatically embedded…

Artificial Intelligence · Computer Science 2022-12-22 Oskar Wysocki , Jessica Katharine Davies , Markel Vigo , Anne Caroline Armstrong , Dónal Landers , Rebecca Lee , André Freitas

Interpretability in machine learning models is important in high-stakes decisions, such as whether to order a biopsy based on a mammographic exam. Mammography poses important challenges that are not present in other computer vision tasks:…

Machine Learning · Computer Science 2021-03-24 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

In modern business processes, the amount of data collected has increased substantially in recent years. Because this data can potentially yield valuable insights, automated knowledge extraction based on process mining has been proposed,…

Machine Learning · Computer Science 2022-12-02 Riza Velioglu , Jan Philip Göpfert , André Artelt , Barbara Hammer

Interpretability is becoming an active research topic as machine learning (ML) models are more widely used to make critical decisions. Tabular data is one of the most commonly used modes of data in diverse applications such as healthcare…

Machine Learning · Statistics 2021-12-01 Amirata Ghorbani , Dina Berenbaum , Maor Ivgi , Yuval Dafna , James Zou

The healthcare sector has experienced a rapid accumulation of digital data recently, especially in the form of electronic health records (EHRs). EHRs constitute a precious resource that IS researchers could utilize for clinical applications…

Machine Learning · Computer Science 2024-11-06 Thiti Suttaket , L Vivek Harsha Vardhan , Stanley Kok

Translating machine learning (ML) models effectively to clinical practice requires establishing clinicians' trust. Explainability, or the ability of an ML model to justify its outcomes and assist clinicians in rationalizing the model…

Machine Learning · Computer Science 2019-08-08 Sana Tonekaboni , Shalmali Joshi , Melissa D McCradden , Anna Goldenberg

The interactive machine learning (IML) community aims to augment humans' ability to learn and make decisions over time through the development of automated decision-making systems. This interaction represents a collaboration between…

Human-Computer Interaction · Computer Science 2019-05-16 Kory W. Mathewson

The lack of transparency and explainability hinders the clinical adoption of Machine learning (ML) algorithms. While explainable artificial intelligence (XAI) methods have been proposed, little research has focused on the agreement between…

Machine Learning · Computer Science 2023-11-29 Aida Brankovic , Wenjie Huang , David Cook , Sankalp Khanna , Konstanty Bialkowski

Many risk-sensitive applications require Machine Learning (ML) models to be interpretable. Attempts to obtain interpretable models typically rely on tuning, by trial-and-error, hyper-parameters of model complexity that are only loosely…

Machine Learning · Computer Science 2020-05-29 Marco Virgolin , Andrea De Lorenzo , Eric Medvet , Francesca Randone

Interpretability can be critical for the safe and responsible use of machine learning models in high-stakes applications. So far, evolutionary computation (EC), in particular in the form of genetic programming (GP), represents a key enabler…

Neural and Evolutionary Computing · Computer Science 2022-04-06 Marco Virgolin , Eric Medvet , Tanja Alderliesten , Peter A. N. Bosman

Electronic patient records (EPRs) produce a wealth of data but contain significant missing information. Understanding and handling this missing data is an important part of clinical data analysis and if left unaddressed could result in bias…

Machine Learning · Computer Science 2024-02-12 Neslihan Suzen , Evgeny M. Mirkes , Damian Roland , Jeremy Levesley , Alexander N. Gorban , Tim J. Coats

Production machine learning (ML) systems fail silently -- not with crashes, but through wrong decisions. While observability is recognized as critical for ML operations, there is a lack empirical evidence of what practitioners actually…

Software Engineering · Computer Science 2025-10-29 Joran Leest , Ilias Gerostathopoulos , Patricia Lago , Claudia Raibulet

The estimation of missing input vector elements in real time processing applications requires a system that possesses the knowledge of certain characteristics such as correlations between variables, which are inherent in the input space.…

Applications · Statistics 2007-05-23 Fulufhelo V. Nelwamondo , Shakir Mohamed , Tshilidzi Marwala

In this paper, we highlight three issues that limit performance of machine learning on biomedical images, and tackle them through 3 case studies: 1) Interactive Machine Learning (IML): we show how IML can drastically improve exploration…

Computer Vision and Pattern Recognition · Computer Science 2019-02-18 Naimul Mefraz Khan , Nabila Abraham , Ling Guan

Machine unlearning techniques aim to mitigate unintended memorization in large language models (LLMs). However, existing approaches predominantly focus on the explicit removal of isolated facts, often overlooking latent inferential…

Interpretable entity representations (IERs) are sparse embeddings that are "human-readable" in that dimensions correspond to fine-grained entity types and values are predicted probabilities that a given entity is of the corresponding type.…

Computation and Language · Computer Science 2022-12-06 Diego Garcia-Olano , Yasumasa Onoe , Joydeep Ghosh , Byron C. Wallace

Time series data with missing values is common across many domains. Healthcare presents special challenges due to prolonged periods of sensor disconnection. In such cases, having a confidence measure for imputed values is critical. Most…

Machine Learning · Computer Science 2025-07-15 Addison Weatherhead , Anna Goldenberg
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