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Efficient and robust bioprocess control is essential for maximizing performance and adaptability in advanced biotechnological systems. In this work, we present a reinforcement-learning framework for multi-setpoint and multi-trajectory…

Systems and Control · Electrical Eng. & Systems 2025-07-29 Sebastián Espinel-Ríos , José L. Avalos , Ehecatl Antonio del Rio Chanona , Dongda Zhang

While reinforcement learning has made great improvements, state-of-the-art algorithms can still struggle with seemingly simple set-point feedback control problems. One reason for this is that the learned controller may not be able to excite…

Systems and Control · Electrical Eng. & Systems 2023-04-21 Ruoqi Zhang , Per Mattsson , Torbjörn Wigren

Dynamic metabolic control allows key metabolic fluxes to be modulated in real time, enhancing bioprocess flexibility and expanding available optimization degrees of freedom. This is achieved, e.g., via targeted modulation of metabolic…

Systems and Control · Electrical Eng. & Systems 2025-10-03 Sebastián Espinel-Ríos , River Walser , Dongda Zhang

Reinforcement learning (RL) is a framework to optimize a control policy using rewards that are revealed by the system as a response to a control action. In its standard form, RL involves a single agent that uses its policy to accomplish a…

Systems and Control · Electrical Eng. & Systems 2021-11-24 Juan Cervino , Juan Andres Bazerque , Miguel Calvo-Fullana , Alejandro Ribeiro

Bioprocesses have received a lot of attention to produce clean and sustainable alternatives to fossil-based materials. However, they are generally difficult to optimize due to their unsteady-state operation modes and stochastic behaviours.…

Given a list of behaviors and associated parameterized controllers for solving different individual tasks, we study the problem of selecting an optimal sequence of coordinated behaviors in multi-robot systems for completing a given mission,…

Robotics · Computer Science 2019-09-16 Pietro Pierpaoli , Thinh T. Doan , Justin Romberg , Magnus Egerstedt

The ability to autonomously explore and resolve tasks with minimal human guidance is crucial for the self-development of embodied intelligence. Although reinforcement learning methods can largely ease human effort, it's challenging to…

Robotics · Computer Science 2024-12-19 Changxin Huang , Yanbin Chang , Junfan Lin , Junyang Liang , Runhao Zeng , Jianqiang Li

Recently, evolutionary reinforcement learning has obtained much attention in various domains. Maintaining a population of actors, evolutionary reinforcement learning utilises the collected experiences to improve the behaviour policy through…

Neural and Evolutionary Computing · Computer Science 2024-08-02 Chengpeng Hu , Jialin Liu , Xin Yao

Reinforcement learning demonstrated immense success in modelling complex physics-driven systems, providing end-to-end trainable solutions by interacting with a simulated or real environment, maximizing a scalar reward signal. In this work,…

Computational Physics · Physics 2025-01-10 Tobias Kortus , Ralf Keidel , Nicolas R. Gauger , Jan Kieseler

Designing an effective reward function has long been a challenge in reinforcement learning, particularly for complex tasks in unstructured environments. To address this, various learning paradigms have emerged that leverage different forms…

Machine Learning · Computer Science 2025-04-29 Muhammad Qasim Elahi , Somtochukwu Oguchienti , Maheed H. Ahmed , Mahsa Ghasemi

We enable reinforcement learning agents to learn successful behavior policies by utilizing relevant pre-existing teacher policies. The teacher policies are introduced as objectives, in addition to the task objective, in a multi-objective…

Machine Learning · Computer Science 2023-08-31 Shruti Mishra , Ankit Anand , Jordan Hoffmann , Nicolas Heess , Martin Riedmiller , Abbas Abdolmaleki , Doina Precup

This research focuses on enhancing reinforcement learning (RL) algorithms by integrating penalty functions to guide agents in avoiding unwanted actions while optimizing rewards. The goal is to improve the learning process by ensuring that…

Machine Learning · Computer Science 2025-04-07 Sai Gana Sandeep Pula , Sathish A. P. Kumar , Sumit Jha , Arvind Ramanathan

In this work we introduce reinforcement learning techniques for solving lexicographic multi-objective problems. These are problems that involve multiple reward signals, and where the goal is to learn a policy that maximises the first reward…

Machine Learning · Computer Science 2022-12-29 Joar Skalse , Lewis Hammond , Charlie Griffin , Alessandro Abate

In Multi-Goal Reinforcement Learning, an agent learns to achieve multiple goals with a goal-conditioned policy. During learning, the agent first collects the trajectories into a replay buffer, and later these trajectories are selected…

Machine Learning · Computer Science 2020-05-26 Rui Zhao , Xudong Sun , Volker Tresp

Biopharmaceutical manufacturing faces critical challenges, including complexity, high variability, lengthy lead time, and limited historical data and knowledge of the underlying system stochastic process. To address these challenges, we…

Machine Learning · Computer Science 2020-06-18 Hua Zheng , Wei Xie , Mingbin Ben Feng

A central goal in ecology is to understand how biodiversity is maintained. Previous theoretical works have employed the rock-paper-scissors (RPS) game as a toy model, demonstrating that population mobility is crucial in determining the…

Populations and Evolution · Quantitative Biology 2026-05-21 Kaiwen Jiang , Chenyang Zhao , Shengfeng Deng , Weiran Cai , Jiqiang Zhang , Li Chen

This paper discusses a system that accelerates reinforcement learning by using transfer from related tasks. Without such transfer, even if two tasks are very similar at some abstract level, an extensive re-learning effort is required. The…

Artificial Intelligence · Computer Science 2011-06-10 C. Drummond

Deep Reinforcement Learning is a promising tool for robotic control, yet practical application is often hindered by the difficulty of designing effective reward functions. Real-world tasks typically require optimizing multiple objectives…

Machine Learning · Computer Science 2026-03-06 Kilian Freitag , Knut Åkesson , Morteza Haghir Chehreghani

Reinforcement learning has shown great promise in robotics thanks to its ability to develop efficient robotic control procedures through self-training. In particular, reinforcement learning has been successfully applied to solving the…

Robotics · Computer Science 2020-11-12 Pierre Aumjaud , David McAuliffe , Francisco Javier Rodríguez Lera , Philip Cardiff

We are motivated by the real challenges presented in a human-robot system to develop new designs that are efficient at data level and with performance guarantees such as stability and optimality at systems level. Existing…

Systems and Control · Electrical Eng. & Systems 2021-01-19 Xiang Gao , Jennie Si , Yue Wen , Minhan Li , He , Huang
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