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Realizing general inverse design could greatly accelerate the discovery of new materials with user-defined properties. However, state-of-the-art generative models tend to be limited to a specific composition or crystal structure. Herein, we…

Crystalline structure prediction is an essential prerequisite for designing materials with targeted properties. Yet, it is still an open challenge in materials design and drug discovery. Despite recent advances in computational materials…

Machine Learning · Computer Science 2025-09-29 Emmanuel Jehanno , Romain Menegaux , Julien Mairal , Sergei Grudinin

Constructing a quantum description of crystals from scattering experiments is of paramount importance to explain their macroscopic properties and to evaluate the pertinence of theoretical ab-initio models. While reconstruction methods of…

Materials Science · Physics 2019-04-19 Benjamin De Bruyne , Jean-Michel Gillet

The constant demand for new functional materials calls for efficient strategies to accelerate the materials design and discovery. In addressing this challenge, machine learning generative models can offer promising opportunities since they…

Materials Science · Physics 2020-06-24 Sungwon Kim , Juhwan Noh , Geun Ho Gu , Alán Aspuru-Guzik , Yousung Jung

Amorphous (disordered) materials are solids that have shown great potential in various domains, including energy storage, thermal management, and advanced materials. Unlike crystalline materials that can be described by unit cells…

Machine Learning · Computer Science 2026-05-01 Yan Lin , Jilin Hu , N. M. Anoop Krishnan , Morten M. Smedskjaer

An algorithm for determining crystal structures from diffraction data is described which does not rely on the usual Fourier-space formulations of atomicity. The new algorithm implements atomicity constraints in real-space, as well as…

Condensed Matter · Physics 2007-05-23 Veit Elser

Accessing the synthesizability of crystal structures is pivotal for advancing the practical application of theoretical material structures designed by machine learning or high-throughput screening. However, a significant gap exists between…

Materials Science · Physics 2024-07-10 Zhilong Song , Shuaihua Lu , Minggang Ju , Qionghua Zhou , Jinlan Wang

The complexity of condensed matter arises from emergent behaviors that cannot be understood by analyzing individual constituents in isolation. While traditional condensed-matter approaches-developed primarily for ideal crystalline…

Materials Science · Physics 2025-09-30 Elisabetta Nocerino

In silico design and optimization of new materials primarily relies on high-accuracy atomic simulators that perform density functional theory (DFT) calculations. While recent works showcase the strong potential of machine learning to…

Machine Learning · Computer Science 2025-09-30 Prashant Govindarajan , Mathieu Reymond , Antoine Clavaud , Mariano Phielipp , Santiago Miret , Sarath Chandar

Discovering crystal structures with specific chemical properties has become an increasingly important focus in material science. However, current models are limited in their ability to generate new crystal lattices, as they only consider…

Materials Science · Physics 2024-01-12 Astrid Klipfel , Yaël Fregier , Adlane Sayede , Zied Bouraoui

Efficient heuristics have predicted many functional materials such as high-temperature superconducting hydrides, while inorganic structural chemistry explains why and how the crystal structures are stabilized. Here we develop the paired…

Materials Science · Physics 2024-11-07 Ryotaro Koshoji , Taisuke Ozaki

Crystal-structure phase mapping is a core, long-standing challenge in materials science that requires identifying crystal structures, or mixtures thereof, in synthesized materials. Materials science experts excel at solving simple systems…

The prediction of material structure from chemical composition has been a long-standing challenge in natural science. Although there have been various methodological developments and successes with computer simulations, the prediction of…

Materials Science · Physics 2018-05-23 Naoto Tsujimoto , Daiki Adachi , Ryosuke Akashi , Synge Todo , Shinji Tsuneyuki

Advances in generative artificial intelligence are transforming how metal-organic frameworks (MOFs) are designed and discovered. This Perspective introduces the shift from laborious enumeration of MOF candidates to generative approaches…

Data-driven generative models excel in language and vision, but diffusion models often fail in constrained planning and design tasks, exhibiting severe constraint violations in engineering inverse design, molecular generation, multi-robot…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Zirui Zhao , Boye Niu , Harold Soh , David Hsu , Wee Sun Lee

Metastable materials are abundant in nature and technology, showcasing remarkable properties that inspire innovative materials design. However, traditional crystal structure prediction methods, which rely solely on energetic factors to…

Materials Science · Physics 2023-11-27 Busheng Wang , Katerina P. Hilleke , Samad Hajinazar , Gilles Frapper , Eva Zurek

The growth of crystals confined in porous or cellular materials is ubiquitous in Nature and industry. Confinement affects the formation of biominerals in living organisms, of minerals in the Earth's crust and of salt crystals damaging…

Materials Science · Physics 2022-11-30 Felix Kohler , Olivier Pierre-Louis , Dag Kristian Dysthe

Topological constraint theory has become an increasingly popular tool to predict the compositional dependence of glass properties or pinpoint promising compositions with tailored functionalities. This approach reduces complex disordered…

Disordered Systems and Neural Networks · Physics 2020-06-16 Mathieu Bauchy

Complex networks theory has commonly been used for modelling and understanding the interactions taking place between the elements composing complex systems. More recently, the use of generative models has gained momentum, as they allow…

Physics and Society · Physics 2016-05-19 Massimiliano Zanin , Marco Correia , Pedro A. C. Sousa , Jorge Cruz

Molecular crystal structure prediction represents a grand challenge in computational chemistry due to large sizes of constituent molecules and complex intra- and intermolecular interactions. While generative modeling has revolutionized…

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