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In the last decade, various robotic platforms have been introduced that could support delicate retinal surgeries. Concurrently, to provide semantic understanding of the surgical area, recent advances have enabled microscope-integrated…

Recent advancements in retinal surgery have paved the way for a modern operating room equipped with a surgical robot, a microscope, and intraoperative optical coherence tomography (iOCT)- a depth sensor widely used in retinal surgery.…

Subretinal injection is a delicate vitreoretinal procedure requiring precise needle placement within the subretinal space while avoiding perforation of the retinal pigment epithelium (RPE), a layer directly beneath the target with extremely…

Subretinal injection is a critical procedure for delivering therapeutic agents to treat retinal diseases such as age-related macular degeneration (AMD). However, retinal motion caused by physiological factors such as respiration and…

Achieving precise control of robotic tool paths is often challenged by inherent system misalignments, unmodeled dynamics, and actuation inaccuracies. This work introduces an Iterative Learning Control (ILC) strategy to enable precise…

Robotics · Computer Science 2025-11-04 Yasamin Foroutani , Yasamin Mousavi-Motlagh , Aya Barzelay , Tsu-Chin Tsao

Robotic ophthalmic surgery is an emerging technology to facilitate high-precision interventions such as retina penetration in subretinal injection and removal of floating tissues in retinal detachment depending on the input imaging…

Robotics · Computer Science 2023-11-16 Junjie Yang , Zhihao Zhao , Siyuan Shen , Daniel Zapp , Mathias Maier , Kai Huang , Nassir Navab , M. Ali Nasseri

Exudative (wet) age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, typically treated with intravitreal injections. Emerging therapies, such as subretinal injections of stem cells, gene therapy, small…

During retinal microsurgery, precise manipulation of the delicate retinal tissue is required for positive surgical outcome. However, accurate manipulation and navigation of surgical tools remain difficult due to a constrained workspace and…

Robotics · Computer Science 2020-11-17 Ji Woong Kim , Peiyao Zhang , Peter Gehlbach , Iulian Iordachita , Marin Kobilarov

Purpose. Intraoperative Optical Coherence Tomography (iOCT) is an increasingly available imaging technique for ophthalmic microsurgery that provides high-resolution cross-sectional information of the surgical scene. We propose to build on…

Computer Vision and Pattern Recognition · Computer Science 2018-02-20 Jakob Weiss , Nicola Rieke , Mohammad Ali Nasseri , Mathias Maier , Abouzar Eslami , Nassir Navab

We propose a general strategy for autonomous guidance and insertion of a needle into a retinal blood vessel. The main challenges underpinning this task are the accurate placement of the needle-tip on the target vein and a careful needle…

Robotics · Computer Science 2023-06-21 Ji Woong Kim , Peiyao Zhang , Peter Gehlbach , Iulian Iordachita , Marin Kobilarov

Subretinal injection methods and other procedures for treating retinal conditions and diseases (many considered incurable) have been limited in scope due to limited human motor control. This study demonstrates the next generation,…

Robotic automation has the potential to assist human surgeons in performing suturing tasks in microsurgery, and in order to do so a robot must be able to guide a needle with sub-millimeter precision through soft tissue. This paper presents…

Robotics · Computer Science 2020-03-16 Yuan Tian , Mark Draelos , Gao Tang , Ruobing Qian , Anthony Kuo , Joseph Izatt , Kris Hauser

Ultrasound-guided percutaneous needle insertion is a standard procedure employed in both biopsy and ablation in clinical practices. However, due to the complex interaction between tissue and instrument, the needle may deviate from the…

A fundamental challenge in retinal surgery is safely navigating a surgical tool to a desired goal position on the retinal surface while avoiding damage to surrounding tissues, a procedure that typically requires tens-of-microns accuracy. In…

Important challenges in retinal microsurgery include prolonged operating time, inadequate force feedback, and poor depth perception due to a constrained top-down view of the surgery. The introduction of robot-assisted technology could…

Robotics · Computer Science 2023-12-08 Peiyao Zhang , Ji Woong Kim , Peter Gehlbach , Iulian Iordachita , Marin Kobilarov

Several robotic frameworks have been recently developed to assist ophthalmic surgeons in performing complex vitreoretinal procedures such as subretinal injection of advanced therapeutics. These surgical robots show promising capabilities;…

Robotics · Computer Science 2025-02-26 Satoshi Inagaki , Alireza Alikhani , Nassir Navab , Peter C. Issa , M. Ali Nasseri

The multi-modality imaging system offers optimal fused images for safe and precise interventions in modern clinical practices, such as computed tomography - ultrasound (CT-US) guidance for needle insertion. However, the limited dexterity…

Robotics · Computer Science 2025-02-18 Feng Li , Yuan Bi , Dianye Huang , Zhongliang Jiang , Nassir Navab

In various surgical procedures, regions of interest (ROIs) such as organs or lesions are often occluded by overlying tissues, requiring surgeons to achieve adequate exposure for precise intervention. However, the irregular geometry,…

Robotics · Computer Science 2026-05-19 Jiayi Liu , Kaiqi Wei , Yiwei Wang , Huan Zhao , Han Ding

Purpose: The integration of multimodal imaging into operating rooms paves the way for comprehensive surgical scene understanding. In ophthalmic surgery, by now, two complementary imaging modalities are available: operating microscope (OPMI)…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Nikolo Rohrmoser , Ghazal Ghazaei , Michael Sommersperger , Nassir Navab

Vitreoretinal surgery pertains to the treatment of delicate tissues on the fundus of the eye using thin instruments. Surgeons frequently rotate the eye during surgery, which is called orbital manipulation, to observe regions around the…

Robotics · Computer Science 2023-07-10 Yuki Koyama , Murilo Marques Marinho , Kanako Harada
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