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Understanding the decision-making processes of neural networks is a central goal of mechanistic interpretability. In the context of Large Language Models (LLMs), this involves uncovering the underlying mechanisms and identifying the roles…

Computation and Language · Computer Science 2026-04-21 Nils Feldhus , Laura Kopf

Vision-language models are integral to computer vision research, yet many high-performing models remain closed-source, obscuring their data, design and training recipe. The research community has responded by using distillation from…

Large Language Models (LLMs) excel at generating fluent text but struggle to enforce external constraints because they generate tokens sequentially without explicit control mechanisms. GenCP addresses this limitation by combining LLM…

Computation and Language · Computer Science 2025-06-02 Alexandre Bonlarron , Florian Régin , Elisabetta De Maria , Jean-Charles Régin

Multilingual language models (MLLMs) have demonstrated remarkable abilities to transfer knowledge across languages, despite being trained without explicit cross-lingual supervision. We analyze the parameter spaces of three MLLMs to study…

Computation and Language · Computer Science 2025-06-03 Frederick Riemenschneider , Anette Frank

Self-supervised training of language models (LMs) has seen great success for protein sequences in learning meaningful representations and for generative drug design. Most protein LMs are based on the Transformer architecture trained on…

Biomolecules · Quantitative Biology 2025-04-03 Yingheng Wang , Zichen Wang , Gil Sadeh , Luca Zancato , Alessandro Achille , George Karypis , Huzefa Rangwala

Reparameterized diffusion models (RDMs) have recently matched autoregressive methods in protein generation, motivating their use for challenging tasks such as designing membrane proteins, which possess interleaved soluble and transmembrane…

Biomolecules · Quantitative Biology 2025-09-30 Shrey Goel , Peregrine M. Schray , Yinuo Zhang , Sophia Vincoff , Huong T. Kratochvil , Pranam Chatterjee

Revolutionizing drug discovery demands more than just understanding molecular interactions - it requires generative models that can design novel ligands tailored to specific biological targets. While chemical Language Models (cLMs) have…

The emergence of Multimodal Large Language Models (MLLMs) has revolutionized image understanding by bridging textual and visual modalities. However, these models often struggle with capturing fine-grained semantic information, such as the…

Computer Vision and Pattern Recognition · Computer Science 2025-07-16 Jie Yang , Wang Zeng , Sheng Jin , Lumin Xu , Wentao Liu , Chen Qian , Zhen Li , Ruimao Zhang

As AI models grow larger, the demand for accountability and interpretability has become increasingly critical for understanding their decision-making processes. Concept Bottleneck Models (CBMs) have gained attention for enhancing…

Machine Learning · Computer Science 2024-10-10 Angelos Ragkousis , Sonali Parbhoo

An exhaustive study on neural network language modeling (NNLM) is performed in this paper. Different architectures of basic neural network language models are described and examined. A number of different improvements over basic neural…

Computation and Language · Computer Science 2017-08-25 Dengliang Shi

Pre-trained language models learn informative word representations on a large-scale text corpus through self-supervised learning, which has achieved promising performance in fields of natural language processing (NLP) after fine-tuning.…

Computation and Language · Computer Science 2023-10-31 Jian Yang , Xinyu Hu , Gang Xiao , Yulong Shen

Deep learning-based medical image classification techniques are rapidly advancing in medical image analysis, making it crucial to develop accurate and trustworthy models that can be efficiently deployed across diverse clinical scenarios.…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Hangzhou He , Jiachen Tang , Lei Zhu , Kaiwen Li , Yanye Lu

Despite their success in various domains, the growing dependence on GNNs raises a critical concern about the nature of the combinatorial reasoning underlying their predictions, which is often hidden within their black-box architectures.…

Machine Learning · Computer Science 2026-03-03 Yue Niu , Zhaokai Sun , Jiayi Yang , Xiaofeng Cao , Rui Fan , Xin Sun , Hanli Wang , Wei Ye

Language confusion -- where large language models (LLMs) generate unintended languages against the user's need -- remains a critical challenge, especially for English-centric models. We present the first mechanistic interpretability (MI)…

Computation and Language · Computer Science 2025-09-19 Ercong Nie , Helmut Schmid , Hinrich Schütze

Large language models (LLMs) have demonstrated remarkable capabilities for medical question answering and programming, but their potential for generating interpretable computable phenotypes (CPs) is under-explored. In this work, we…

Machine Learning · Computer Science 2025-08-08 Guilherme Seidyo Imai Aldeia , Daniel S. Herman , William G. La Cava

Large transformer-based language models (LMs) trained on huge text corpora have shown unparalleled generation capabilities. However, controlling attributes of the generated language (e.g. switching topic or sentiment) is difficult without…

Computation and Language · Computer Science 2020-03-04 Sumanth Dathathri , Andrea Madotto , Janice Lan , Jane Hung , Eric Frank , Piero Molino , Jason Yosinski , Rosanne Liu

Language models (LMs) are sentence-completion engines trained on massive corpora. LMs have emerged as a significant breakthrough in natural-language processing, providing capabilities that go far beyond sentence completion including…

Artificial Intelligence · Computer Science 2021-10-26 Robert E. Wray , III , James R. Kirk , John E. Laird

Due to the high stakes in medical decision-making, there is a compelling demand for interpretable deep learning methods in medical image analysis. Concept Bottleneck Models (CBM) have emerged as an active interpretable framework…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Yibo Gao , Zheyao Gao , Xin Gao , Yuanye Liu , Bomin Wang , Xiahai Zhuang

The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

Large Language Models (LLMs) have demonstrated amazing capabilities in language generation, text comprehension, and knowledge reasoning. While a single powerful model can already handle multiple tasks, relying on a single perspective can…

Computation and Language · Computer Science 2024-06-12 Zining Qin , Chenhao Wang , Huiling Qin , Weijia Jia
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