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The structural similarities between protein sequences and natural languages have led to parallel advancements in deep learning across both domains. While large language models (LLMs) have achieved much progress in the domain of natural…

Biomolecules · Quantitative Biology 2024-08-29 Yiqing Shen , Zan Chen , Michail Mamalakis , Yungeng Liu , Tianbin Li , Yanzhou Su , Junjun He , Pietro Liò , Yu Guang Wang

Recent advancements in Large Language Models (LLMs) have enhanced efficiency across various domains, including protein engineering, where they offer promising opportunities for dry lab and wet lab experiment workflow automation. Previous…

Quantitative Methods · Quantitative Biology 2024-11-12 Zan Chen , Yungeng Liu , Yu Guang Wang , Yiqing Shen

Protein engineering is important for biomedical applications, but conventional approaches are often inefficient and resource-intensive. While deep learning (DL) models have shown promise, their training or implementation into protein…

Quantitative Methods · Quantitative Biology 2024-11-08 Yungeng Liu , Zan Chen , Yu Guang Wang , Yiqing Shen

Protein analysis tasks arising in healthcare settings often require accurate reasoning under protein sequence constraints, involving tasks such as functional interpretation of disease-related variants, protein-level analysis for clinical…

Artificial Intelligence · Computer Science 2026-03-03 Congying Liu , Taihao Li , Ming Huang , Xingyuan Wei , Peipei Liu , Yiqing Shen , Yanxu Mao , Tiehan Cui

Large language models (LLMs) have garnered considerable attention for their proficiency in tackling intricate tasks, particularly leveraging their capacities for zero-shot and in-context learning. However, their utility has been…

Biomolecules · Quantitative Biology 2024-05-14 Yiqing Shen , Outongyi Lv , Houying Zhu , Yu Guang Wang

Financial decision-making requires processing vast amounts of real-time information while understanding their complex temporal relationships. While traditional search engines excel at providing real-time information access, they often…

Information Retrieval · Computer Science 2025-02-25 Jinzheng Li , Jingshu Zhang , Hongguang Li , Yiqing Shen

Protein scientific discovery is bottlenecked by the manual orchestration of information and algorithms, while general agents are insufficient in complex domain projects. VenusFactory2 provides an autonomous framework that shifts from static…

Artificial Intelligence · Computer Science 2026-03-31 Yang Tan , Lingrong Zhang , Mingchen Li , Yuanxi Yu , Bozitao Zhong , Bingxin Zhou , Nanqing Dong , Liang Hong

With the exponential increase in online scientific literature, identifying reliable domain-specific data has become increasingly important but also very challenging. Manual data collection and filtering for domain-specific scientific…

Information Retrieval · Computer Science 2026-03-10 Nikita Gautam , Doina Caragea , Ignacio Ciampitti , Federico Gomez

Building Large Language Model agents that expand their capabilities by interacting with external tools represents a new frontier in AI research and applications. In this paper, we introduce InfoAgent, a deep research agent powered by an…

Large language model (LLM)-based search agents have proven promising for addressing knowledge-intensive problems by incorporating information retrieval capabilities. Existing works largely focus on optimizing the reasoning paradigms of…

Artificial Intelligence · Computer Science 2026-01-09 Tongyu Wen , Guanting Dong , Zhicheng Dou

Deep Research agents are rapidly emerging as primary consumers of modern retrieval systems. Unlike human users who issue and refine queries without documenting their intermediate thought processes, Deep Research agents generate explicit…

Computation and Language · Computer Science 2026-03-10 Zijian Chen , Xueguang Ma , Shengyao Zhuang , Jimmy Lin , Akari Asai , Victor Zhong

Translational medicine turns underspecified development goals into evidence synthesis that must combine literature, trials, patents, and quantitative multi-omics analysis while preserving identifiers, uncertainty, and retrievable…

Recent advances in deep-research systems have demonstrated the potential for AI agents to autonomously discover and synthesize knowledge from external sources. In this paper, we introduce WebResearcher, a novel framework for building such…

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang

Drug discovery remains a formidable challenge: more than 90 percent of candidate molecules fail in clinical evaluation, and development costs often exceed one billion dollars per approved therapy. Disparate data streams, from genomics and…

Artificial Intelligence · Computer Science 2025-04-28 Kevin Song , Andrew Trotter , Jake Y. Chen

Modern search systems play a crucial role in facilitating information acquisition. Traditional search engines typically rely on a cascaded architecture, where results are retrieved through recall, pre-ranking, and ranking stages. The…

Automatic research with Large Language Models (LLMs) is rapidly gaining importance, driving the development of increasingly complex workflows involving multi-agent systems, planning, tool usage, code execution, and human-agent interaction…

Computation and Language · Computer Science 2025-10-09 Haofei Yu , Keyang Xuan , Fenghai Li , Kunlun Zhu , Zijie Lei , Jiaxun Zhang , Ziheng Qi , Kyle Richardson , Jiaxuan You

The global demand for sustainable protein sources has accelerated the need for intelligent tools that can rapidly process and synthesise domain-specific scientific knowledge. In this study, we present a proof-of-concept multi-agent…

Artificial Intelligence · Computer Science 2025-06-26 Alexander D. Kalian , Jaewook Lee , Stefan P. Johannesson , Lennart Otte , Christer Hogstrand , Miao Guo

Autonomous agents powered by language models (LMs) have demonstrated promise in their ability to perform decision-making tasks such as web automation. However, a key limitation remains: LMs, primarily optimized for natural language…

Artificial Intelligence · Computer Science 2026-02-10 Jing Yu Koh , Stephen McAleer , Daniel Fried , Ruslan Salakhutdinov

Research Agents enable models to gather information from the web using tools to answer user queries, requiring them to dynamically interleave internal reasoning with tool use. While such capabilities can in principle be learned via…

Artificial Intelligence · Computer Science 2026-03-10 Hansi Zeng , Zoey Li , Yifan Gao , Chenwei Zhang , Xiaoman Pan , Tao Yang , Fengran Mo , Jiacheng Lin , Xian Li , Jingbo Shang
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