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This research paper investigates the application of Large Language Models (LLMs) in healthcare, specifically focusing on enhancing medical decision support through Retrieval-Augmented Generation (RAG) integrated with hospital-specific data…

Computation and Language · Computer Science 2025-05-07 Mohammad Shoaib Ansari , Mohd Sohail Ali Khan , Shubham Revankar , Aditya Varma , Anil S. Mokhade

In this study, we expand upon the FLIP benchmark-designed for evaluating protein fitness prediction models in small, specialized prediction tasks-by assessing the performance of state-of-the-art large protein language models, including…

Machine Learning · Computer Science 2025-01-31 Manuel F. Mollon , Joaquin Gonzalez-Rodriguez , Alicia Lozano-Diez , Daniel Ramos , Doroteo T. Toledano

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Artificial Intelligence · Computer Science 2025-04-21 Yijia Xiao , Edward Sun , Yiqiao Jin , Qifan Wang , Wei Wang

Large language models have demonstrated impressive capabilities across various domains. However, their general-purpose nature often limits their effectiveness in specialized fields such as energy, where deep technical expertise and precise…

Computation and Language · Computer Science 2026-04-15 Amal Chebbi , Babajide Kolade

This study examines whether Low-Rank Adaptation (LoRA) fine-tuned Large Language Models (LLMs) can approximate the performance of fully fine-tuned models in generating human-interpretable decisions and explanations for malware…

Cryptography and Security · Computer Science 2025-11-26 Stephen C. Gravereaux , Sheikh Rabiul Islam

As large language models (LLMs) continue to scale in size, the computational overhead has become a major bottleneck for task-specific fine-tuning. While low-rank adaptation (LoRA) effectively curtails this cost by confining the weight…

Machine Learning · Computer Science 2026-05-15 Yilang Zhang , Xiaodong Yang , Yiwei Cai , Georgios B. Giannakis

Recently years have witnessed a rapid development of large language models (LLMs). Despite the strong ability in many language-understanding tasks, the heavy computational burden largely restricts the application of LLMs especially when one…

Machine Learning · Computer Science 2023-10-10 Yuhui Xu , Lingxi Xie , Xiaotao Gu , Xin Chen , Heng Chang , Hengheng Zhang , Zhengsu Chen , Xiaopeng Zhang , Qi Tian

Artificially intelligent (AI) co-scientists must be able to sift through research literature cost-efficiently while applying nuanced scientific reasoning. We evaluate Small Language Models (SLMs, <= 8B parameters) for classifying medical…

Computational Engineering, Finance, and Science · Computer Science 2025-12-09 Muhammed Muaaz Dawood , Mohammad Zaid Moonsamy , Kaela Kokkas , Hairong Wang , Robert F. Breiman , Richard Klein , Emmanuel K. Sekyi , Bruce A. Bassett

In recent years, transformer-based large language models (LLMs) have revolutionised natural language processing (NLP), with generative models opening new possibilities for tasks that require context-aware text generation. Requirements…

Computation and Language · Computer Science 2025-04-24 Waad Alhoshan , Alessio Ferrari , Liping Zhao

Language Models (LMs) excel in understanding textual descriptions of proteins, as evident in biomedical question-answering tasks. However, their capability falters with raw protein data, such as amino acid sequences, due to a deficit in…

Quantitative Methods · Quantitative Biology 2024-05-22 Zhiyuan Liu , An Zhang , Hao Fei , Enzhi Zhang , Xiang Wang , Kenji Kawaguchi , Tat-Seng Chua

Large language models (LLMs) have achieved impressive results in a wide range of natural language applications. However, they often struggle to recognize low-resource languages, in particular African languages, which are not well…

Computation and Language · Computer Science 2025-04-10 Happy Buzaaba , Alexander Wettig , David Ifeoluwa Adelani , Christiane Fellbaum

Protein research is crucial in various fundamental disciplines, but understanding their intricate structure-function relationships remains challenging. Recent Large Language Models (LLMs) have made significant strides in comprehending…

Computational Engineering, Finance, and Science · Computer Science 2025-01-24 Chao Wang , Hehe Fan , Ruijie Quan , Yi Yang

Large language models (LLMs) have demonstrated strong capabilities in generating executable code from natural language descriptions. However, general-purpose models often struggle in specialized programming contexts where domain-specific…

Artificial Intelligence · Computer Science 2026-03-18 Luís Freire , Fernanda A. Andaló , Nicki Skafte Detlefsen

In recent years, Large Language Models (LLMs) have demonstrated remarkable capabilities across a wide range of natural language processing (NLP) tasks, such as question-answering, sentiment analysis, text summarization, and machine…

Machine Learning · Computer Science 2024-08-05 Afia Anjum , Maksim E. Eren , Ismael Boureima , Boian Alexandrov , Manish Bhattarai

Although Large Language Models (LLMs) have shown promise for human-like conversations, they are primarily pre-trained on text data. Incorporating audio or video improves performance, but collecting large-scale multimodal data and…

Protein language models (PLMs) face a fundamental divide: masked language models (MLMs) excel at fitness prediction while causal models enable generation, forcing practitioners to maintain separate architectures. We introduce…

Machine Learning · Computer Science 2026-02-03 Furkan Eris

Parameter-Efficient Fine-Tuning (PEFT), particularly Low-Rank Adaptation (LoRA), has become a standard approach for adapting Large Language Models (LLMs) under limited compute. However, in continual settings where models are updated…

Machine Learning · Computer Science 2026-05-14 Hung Le , Svetha Venkatesh

Parameter-efficient methods like LoRA have revolutionised large language model (LLM) fine-tuning. ReLoRA extends this idea to pretraining by repeatedly merging and reinitialising low-rank adapters, increasing cumulative rank while keeping…

Computation and Language · Computer Science 2025-10-03 Yuval Weiss , David Demitri Africa , Paula Buttery , Richard Diehl Martinez

Large Language Models (LLMs) have the potential to accelerate small molecule drug design due to their ability to reason about information from diverse sources and formats. However, their practical utility remains unclear due to the lack of…

How cost-effectively can strong reasoning abilities be achieved in language models? Driven by this fundamental question, we present Tina, a family of tiny reasoning models achieved with high cost-efficiency. Notably, Tina demonstrates that…

Computation and Language · Computer Science 2025-06-13 Shangshang Wang , Julian Asilis , Ömer Faruk Akgül , Enes Burak Bilgin , Ollie Liu , Willie Neiswanger