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Purpose: We proposed a deep convolutional neural network (CNN), named Retinal Fluid Segmentation Network (ReF-Net) to segment volumetric retinal fluid on optical coherence tomography (OCT) volume. Methods: 3 x 3-mm OCT scans were acquired…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Yukun Guo , Tristan T. Hormel , Honglian Xiong , Jie Wang , Thomas S. Hwang , Yali Jia

Retinal Optical Coherence Tomography (OCT), a noninvasive cross-sectional scan of the eye with qualitative 3D visualization of the retinal anatomy is use to study the retinal structure and the presence of pathogens. The advent of the…

Image and Video Processing · Electrical Eng. & Systems 2023-02-28 Nchongmaje Ndipenoch , Alina Miron , Zidong Wang , Yongmin Li

Purpose: Microaneurysms (MAs) have distinct, oval-shaped, hyperreflective walls on structural OCT, and inconsistent flow signal in the lumen with OCT angiography (OCTA). Their relationship to regional macular edema in diabetic retinopathy…

Quantitative Methods · Quantitative Biology 2023-10-11 Min Gao , Tristan T. Hormel , Yukun Guo , Kotaro Tsuboi , Christina J. Flaxel , David Huang , Thomas S. Hwang , Yali Jia

The treatment of age-related macular degeneration (AMD) requires continuous eye exams using optical coherence tomography (OCT). The need for treatment is determined by the presence or change of disease-specific OCT-based biomarkers.…

Image and Video Processing · Electrical Eng. & Systems 2026-03-12 Timo Kepp , Helge Sudkamp , Claus von der Burchard , Hendrik Schenke , Peter Koch , Gereon Hüttmann , Johann Roider , Mattias P. Heinrich , Heinz Handels

Purpose: Optical Coherence Tomography Angiography (OCT-A) permits visualization of the changes to the retinal circulation due to diabetic retinopathy (DR), a microvascular complication of diabetes. We demonstrate accurate segmentation of…

Image and Video Processing · Electrical Eng. & Systems 2021-01-13 Julian Lo , Morgan Heisler , Vinicius Vanzan , Sonja Karst , Ivana Zadro Matovinovic , Sven Loncaric , Eduardo V. Navajas , Mirza Faisal Beg , Marinko V. Sarunic

Worldwide, sight loss is commonly occurred by retinal diseases, with age-related macular degeneration (AMD) being a notable facet that affects elderly patients. Approaching 170 million persons wide-ranging have been spotted with AMD, a…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Khaled Al-Saih , Fares Al-Shargie , Mohammed Isam Al-hiyali , Reham Alhejaili

Optical Coherence Tomography (OCT) provides a unique ability to image the eye retina in 3D at micrometer resolution and gives ophthalmologist the ability to visualize retinal diseases such as Age-Related Macular Degeneration (AMD). While…

Computer Vision and Pattern Recognition · Computer Science 2016-10-13 Stefanos Apostolopoulos , Carlos Ciller , Sandro I. De Zanet , Sebastian Wolf , Raphael Sznitman

Retinal neovascularization (RNV) is a vision threatening development in diabetic retinopathy (DR). Vision loss associated with RNV is preventable with timely intervention, making RNV clinical screening and monitoring a priority. Optical…

Image and Video Processing · Electrical Eng. & Systems 2026-04-01 Jinyi Hao , Jie Wang , Liqin Gao , Tristan T. Hormel , Yukun Guo , An-Lun Wu , Christina J. Flaxel , Steven T. Bailey , Kotaro Tsuboi , Thomas S. Hwang , Yali Jia

Our objective is to evaluate the efficacy of methods that use deep learning (DL) for the automatic fine-grained segmentation of optical coherence tomography (OCT) images of the retina. OCT images from 10 patients with mild non-proliferative…

Computer Vision and Pattern Recognition · Computer Science 2018-01-31 Mike Pekala , Neil Joshi , David E. Freund , Neil M. Bressler , Delia Cabrera DeBuc , Philippe M Burlina

Optical coherence tomography (OCT) is a non-invasive 3D modality widely used in ophthalmology for imaging the retina. Achieving automated, anatomically coherent retinal layer segmentation on OCT is important for the detection and monitoring…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Botond Fazekas , Guilherme Aresta , Dmitrii Lachinov , Sophie Riedl , Julia Mai , Ursula Schmidt-Erfurth , Hrvoje Bogunovic

Purpose: Disease progression of retinal atrophy associated with AMD requires the accurate quantification of the retinal atrophy changes on longitudinal OCT studies. It is based on finding, comparing, and delineating subtle atrophy changes…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Adi Szeskin , Roei Yehuda , Or Shmueli , Jaime Levy , Leo Joskowicz

Optical Coherence Tomography Angiography (OCTA) is a non-invasive and non-contacting imaging technique providing visualization of microvasculature of retina and optic nerve head in human eyes in vivo. The adequate image quality of OCTA is…

Image and Video Processing · Electrical Eng. & Systems 2021-07-23 Yufei Wang , Yiqing Shen , Meng Yuan , Jing Xu , Bin Yang , Chi Liu , Wenjia Cai , Weijing Cheng , Wei Wang

Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique widely used to study vascular structures and micro-circulation dynamics in the retina and choroid. OCTA has been widely used in clinics for diagnosing…

Image and Video Processing · Electrical Eng. & Systems 2025-08-26 Kejie Chen , Guanbing Gao , Xiaochun Yang , Wenbo Wang , Jing Na

As a non-invasive imaging modality, optical coherence tomography (OCT) can provide micrometer-resolution 3D images of retinal structures. Therefore it is commonly used in the diagnosis of retinal diseases associated with edema in and under…

Computer Vision and Pattern Recognition · Computer Science 2017-10-16 Donghuan Lu , Morgan Heisler , Sieun Lee , Gavin Ding , Marinko V. Sarunic , Mirza Faisal Beg

Optical Coherence Tomography Angiography (OCTA) and its derived en-face projections provide high-resolution visualization of the retinal and choroidal vasculature, which is critical for the rapid and accurate diagnosis of retinal diseases.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Pooya Khosravi , Kun Han , Anthony T. Wu , Arghavan Rezvani , Zexin Feng , Xiaohui Xie

Age-related macular degeneration (AMD) is characterized by early micro-vascular alterations that can be captured non-invasively using optical coherence tomography angiography (OCTA), yet most deep learning (DL) models rely on global…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Margalit G. Mitzner , Moinak Bhattacharya , Zhilin Zou , Chao Chen , Prateek Prasanna

At the present time Optical Coherence Tomography (OCT) is among the most commonly used non-invasive imaging methods for the acquisition of large volumetric scans of human retinal tissues and vasculature. To resolve decisive information from…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 D. Sitenko , B. Boll , C. Schnörr

Optical coherence tomography (OCT) as retina imaging technology is currently used by ophthalmologist as a non-invasive and non-contact method for diagnosis of agerelated degeneration (AMD) and diabetic macular edema (DME) diseases. Fluid…

Image and Video Processing · Electrical Eng. & Systems 2019-12-30 Elyas Rashno , Abdolreza Rashno , Sadegh Fadaei

Purpose: (1) To develop a deep learning algorithm to identify major tissue structures of the optic nerve head (ONH) in 3D optical coherence tomography (OCT) scans; (2) to exploit such information to robustly differentiate among healthy,…

Optical coherence tomography angiography (OCTA) is an imaging technique that allows for non-invasive investigation of the microvasculature in the retina. OCTA uses laser light reflectance to measure moving blood cells. Hereby, it visualizes…

Tissues and Organs · Quantitative Biology 2020-02-11 Astrid M. E. Engberg , Vedrana A. Dahl , Anders B. Dahl
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