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Background: Antimicrobial resistance (AMR) is a major global public health problem, contributing to an estimated 4.95 million deaths in 2019 and projected to cause up to 10 million deaths annually and 100 trillion dollars in cumulative…

Populations and Evolution · Quantitative Biology 2026-01-06 Felipe Schardong , Claudio Jose Struchiner , Luiz Max Carvalho

Antimicrobial resistance (AMR) poses a significant threat to public health by increasing mortality, extending hospital stays, and increasing healthcare costs. It affects people of all ages and affects health services, veterinary medicine,…

Dynamical Systems · Mathematics 2023-06-12 Alissen Peterson , Jhoana P. Romero-Leiton , Pablo Aguirre , Kamal R. Acharya , Bouchra Nasri

Stochastic differential equations are an important modeling class in many disciplines. Consequently, there exist many methods relying on various discretization and numerical integration schemes. In this paper, we propose a novel,…

Machine Learning · Computer Science 2019-05-29 Gabriele Abbati , Philippe Wenk , Michael A Osborne , Andreas Krause , Bernhard Schölkopf , Stefan Bauer

Antimicrobial resistance (AMR) is a risk for patients and a burden for the healthcare system. However, AMR assays typically take several days. This study develops predictive models for AMR based on easily available clinical and…

Advection-Diffusion-Reaction (ADR) Partial Differential Equations (PDEs) appear in a wide spectrum of applications such as chemical reactors, concentration flows, and biological systems. A large number of these applications require the…

Systems and Control · Electrical Eng. & Systems 2022-03-29 Ahmed Elkhashap , Dirk Abel

Antimicrobial-resistant (AMR) microbes are a growing challenge in healthcare, rendering modern medicines ineffective. AMR arises from antibiotic production and bacterial evolution, but quantifying its transmission remains difficult. With…

Machine Learning · Computer Science 2025-02-04 Qian Fu , Yuzhe Zhang , Yanfeng Shu , Ming Ding , Lina Yao , Chen Wang

Antimicrobial resistance (AMR) poses a mounting global health crisis, requiring rapid and reliable prediction frameworks that capture its complex evolutionary dynamics. Traditional antimicrobial susceptibility testing (AST), while accurate,…

Populations and Evolution · Quantitative Biology 2025-11-18 Anshul Bagaria

This paper focuses on the multivariate linear mixed-effects model, including all the correlations between the random effects when the marginal residual terms are assumed uncorrelated and homoscedastic with possibly different standard…

Methodology · Statistics 2017-05-04 Eric Adjakossa , Grégory Nuel

We discuss an inverse approach for atomistic modeling of glassy materials. The focus is on structural modeling and electronic properties of hydrogenated amorphous silicon and glassy GeSe2 alloy. The work is based upon a new approach…

Disordered Systems and Neural Networks · Physics 2009-11-13 Parthapratim Biswas , D. A. Drabold

We present a collection of algorithms which utilize dimensional reduction to perform mesh refinement and study possibly singular solutions of time-dependent partial differential equations. The algorithms are inspired by constructions used…

Numerical Analysis · Mathematics 2007-06-21 Panagiotis Stinis

This article deals with the numerical resolution of backward stochastic differential equations. Firstly, we consider a rather general case where the filtration is generated by a Brownian motion and a Poisson random measure. We provide a…

Probability · Mathematics 2008-12-18 Emmanuel Gobet , Jean-Philippe Lemor

We present a detailed comparison between two adaptive numerical approaches to solve partial differential equations (PDEs), adaptive multiresolution (MR) and adaptive mesh refinement (AMR). Both discretizations are based on finite volumes in…

Numerical Analysis · Mathematics 2016-03-17 Ralf Deiterding , Margarete O. Domingues , Sonia M. Gomes , Kai Schneider

Antimicrobial resistance (AMR) poses a significant public health and economic challenge, increasing treatment costs and reducing antibiotic effectiveness. This study employs machine learning to analyze genomic and epidemiological data from…

Quantitative Methods · Quantitative Biology 2025-09-05 Shubham Mishra , The Anh Han , Bruno Silvester Lopes , Shatha Ghareeb , Zia Ush Shamszaman

Variational inequalities play a pivotal role in a wide array of scientific and engineering applications. This project presents two techniques for adaptive mesh refinement (AMR) in the context of variational inequalities, with a specific…

Numerical Analysis · Mathematics 2025-02-21 Giuliano Stefano Fochesatto

Estimating the gradients for binary variables is a task that arises frequently in various domains, such as training discrete latent variable models. What has been commonly used is a REINFORCE based Monte Carlo estimation method that uses…

Machine Learning · Computer Science 2021-06-01 Alek Dimitriev , Mingyuan Zhou

Cross-species antimicrobial resistance (AMR) prediction is fundamentally an out-of-distribution (OOD) generalization problem: models trained on one set of bacterial taxa must transfer to phylogenetically distinct genomes that may rely on…

Genomics · Quantitative Biology 2026-03-13 Huilin Tai

Obtainable computational efficiency is evaluated when using an Adaptive Mesh Refinement (AMR) strategy in time accurate simulations governed by sets of conservation laws. For a variety of 1D, 2D, and 3D hydro- and magnetohydrodynamic…

Astrophysics · Physics 2009-11-10 R. Keppens , M. Nool , G. Toth , J. P. Goedbloed

Adversarially robust optimization (ARO) has emerged as the *de facto* standard for training models that hedge against adversarial attacks in the test stage. While these models are robust against adversarial attacks, they tend to suffer…

Optimization and Control · Mathematics 2025-06-12 Aras Selvi , Eleonora Kreacic , Mohsen Ghassemi , Vamsi Potluru , Tucker Balch , Manuela Veloso

We investigate signatures of broken time reversal symmetry in stochastic trajectory data, employing the previously introduced three point correlation called mean back relaxation. We specifically investigate data from a simple driven model,…

Soft Condensed Matter · Physics 2026-03-18 Gabriel Knotz , Till M. Muenker , Timo Betz , Matthias Krüger

In a single molecule assay, the motion of a molecular motor is often inferred from measuring the stochastic trajectory of a large probe particle attached to it. We discuss a simple model for this generic set-up taking into account…

Statistical Mechanics · Physics 2012-11-22 Eva Zimmermann , Udo Seifert
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