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Large-language models (LLMs) are rapidly being applied to radiology, enabling automated image interpretation and report generation tasks. Their deployment in clinical practice requires both high diagnostic accuracy and low inference…

Tissues and Organs · Quantitative Biology 2025-11-11 Jyun-Ping Kao

The billion-scale Large Language Models (LLMs) need deployment on expensive server-grade GPUs with large-storage HBMs and abundant computation capability. As LLM-assisted services become popular, achieving cost-effective LLM inference on…

Hardware Architecture · Computer Science 2025-02-25 Lian Liu , Shixin Zhao , Bing Li , Haimeng Ren , Zhaohui Xu , Mengdi Wang , Xiaowei Li , Yinhe Han , Ying Wang

Large Language Model (LLM) inference is widely used in interactive assistants and agentic systems. In latency-sensitive deployments, inference time can become dominated by host-side overheads. Existing approaches typically expose this cost…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-16 Prabhu Vellaisamy , Shreesh Tripathi , Vignesh Natarajan , Surya Santhan Thenarasu , Shawn Blanton , John P. Shen

Large language models (LLMs) are becoming increasingly capable at small parameter scales. At the same time, conventional cloud-centric deployment introduces challenges around data privacy, latency, and cost that are acute in operational…

Hardware Architecture · Computer Science 2026-04-29 Harri Renney , Fouad Trad , Michael Mattarock , Zena Wood

Efficient LLM inference on resource-constrained devices presents significant challenges in compute and memory utilization. Due to limited GPU memory, existing systems offload model weights to CPU memory, incurring substantial I/O overhead…

Machine Learning · Computer Science 2025-05-22 Xiangwen Zhuge , Xu Shen , Zeyu Wang , Fan Dang , Xuan Ding , Danyang Li , Yahui Han , Tianxiang Hao , Zheng Yang

Bottleneck evaluation plays a crucial part in performance tuning of HPC applications, as it directly influences the search for optimizations and the selection of the best hardware for a given code. In this paper, we introduce a new…

Performance · Computer Science 2025-09-11 Aurélien Delval , Pablo de Oliveira Castro , William Jalby , Etienne Renault

We propose a simulation-based approach for performance modeling of parallel applications on high-performance computing platforms. Our approach enables full-system performance modeling: (1) the hardware platform is represented by an abstract…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-11-06 Gen Xu , Huda Ibeid , Xin Jiang , Vjekoslav Svilan , Zhaojuan Bian

On-device machine learning (ML) inference can enable the use of private user data on user devices without revealing them to remote servers. However, a pure on-device solution to private ML inference is impractical for many applications that…

The deployment of large language models (LLMs) presents significant challenges due to their enormous memory footprints, low arithmetic intensity, and stringent latency requirements, particularly during the autoregressive decoding stage.…

Hardware Architecture · Computer Science 2025-11-03 Cenlin Duan , Jianlei Yang , Rubing Yang , Yikun Wang , Yiou Wang , Lingkun Long , Yingjie Qi , Xiaolin He , Ao Zhou , Xueyan Wang , Weisheng Zhao

The significant computational demands of pretrained language models (PLMs), which often require dedicated hardware, present a substantial challenge in serving them efficiently, especially in multi-tenant environments. To address this, we…

Machine Learning · Computer Science 2025-04-25 Jun Zhang , Jue Wang , Huan Li , Lidan Shou , Ke Chen , Gang Chen , Qin Xie , Guiming Xie , Xuejian Gong

This work presents a systematic characterization of Large Language Model (LLM) inference to address fragmented understanding. Through comprehensive experiments, we establish a four-dimensional analytical framework: (1) Two-Phase…

Hardware Architecture · Computer Science 2025-12-02 Haonan Wang , Xuxin Xiao , Mingyu Yan , Zhuoyuan Zhu , Dengke Han , Duo Wang , Wenming Li , Xiaochun Ye , Cunchen Hu , Hongyang Chen , Guangyu Sun

Deep learning kernels exhibit predictable memory accesses and compute patterns, making GPUs' parallel architecture well-suited for their execution. Software and runtime systems for GPUs are optimized to better utilize the stream…

Machine Learning · Computer Science 2024-12-13 Seonho Lee , Amar Phanishayee , Divya Mahajan

Accurate determination of the performance of parallel GPU code typically requires execution-time profiling on target hardware -- an increasingly prohibitive step due to limited access to high-end GPUs. This paper explores whether Large…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-08 Gregory Bolet , Giorgis Georgakoudis , Harshitha Menon , Konstantinos Parasyris , Niranjan Hasabnis , Hayden Estes , Kirk W. Cameron , Gal Oren

There is an urgent and pressing need to optimize usage of Graphical Processing Units (GPUs), which have arguably become one of the most expensive and sought after IT resources. To help with this goal, several of the current generation of…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-09-11 Bekir Turkkan , Pavankumar Murali , Pavithra Harsha , Rohan Arora , Gerard Vanloo , Chandra Narayanaswami

SMEs increasingly seek alternatives to cloud LLM APIs, which raise data privacy concerns. Dedicated cloud GPU instances offer improved privacy but with limited guarantees and ongoing costs, while professional on-premise hardware (A100,…

Machine Learning · Computer Science 2026-01-15 Jonathan Knoop , Hendrik Holtmann

The growing demand for on-device large language model (LLM) inference is driving interest in deploying lightweight, cost-effective AI solutions on edge hardware. Single-board computers (SBCs) such as the Raspberry Pi and Orange Pi offer a…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-12 Tung , Nguyen , Tuyen Nguyen

The rapid growth of generative AI and its integration into everyday workflows have significantly increased the demand for large language model (LLM) inference services. While proprietary models remain popular, recent advancements in…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-01-28 Linyu Wu , Xiaoyuan Liu , Tianneng Shi , Zhe Ye , Dawn Song

Sizing a GPU fleet for LLM inference is harder than it looks. The obvious questions -- how many GPUs, which type, where to split a two-pool fleet -- have no closed-form answers. They depend on the full token-length distribution, the routing…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-18 Huamin Chen , Xunzhuo Liu , Yuhan Liu , Junchen Jiang , Bowei He , Xue Liu

In the fusion community, the use of high performance computing (HPC) has been mostly dominated by heavy-duty plasma simulations, such as those based on particle-in-cell and gyrokinetic codes. However, there has been a growing interest in…

Computational Physics · Physics 2021-06-14 Diogo R. Ferreira

The attention layer, a core component of Transformer-based LLMs, brings out inefficiencies in current GPU systems due to its low operational intensity and the substantial memory requirements of KV caches. We propose a High-bandwidth…

Hardware Architecture · Computer Science 2025-12-19 Myunghyun Rhee , Joonseop Sim , Taeyoung Ahn , Seungyong Lee , Daegun Yoon , Euiseok Kim , Kyoung Park , Youngpyo Joo , Hoshik Kim