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In multi-center clinical research, privacy regulations often prohibit pooling individual-level records, complicating the analysis of time-to-event data. Current federated survival methods frequently require iterative communication or rely…

Applications · Statistics 2026-03-12 Hyojung Jang , Malcolm Risk , Yaojie Wang , Norrina Bai Allen , Xu Shi , Lili Zhao

Objective: To enable privacy-preserving learning of high quality generative and discriminative machine learning models from distributed electronic health records. Methods and Results: We describe general and scalable strategy to build…

Cryptography and Security · Computer Science 2018-06-19 Marina Blanton , Ah Reum Kang , Subhadeep Karan , Jaroslaw Zola

Federated Learning (FL) allows multiple privacy-sensitive applications to leverage their dataset for a global model construction without any disclosure of the information. One of those domains is healthcare, where groups of silos…

Machine Learning · Computer Science 2024-09-06 Usevalad Milasheuski , Luca Barbieri , Bernardo Camajori Tedeschini , Monica Nicoli , Stefano Savazzi

The analysis of data stored in multiple sites has become more popular, raising new concerns about the security of data storage and communication. Federated learning, which does not require centralizing data, is a common approach to…

Machine Learning · Statistics 2026-02-10 Z. F. Wang , X. Y. Zhang , Y-c I. Chang

Federated Learning enables a population of clients, working with a trusted server, to collaboratively learn a shared machine learning model while keeping each client's data within its own local systems. This reduces the risk of exposing…

Cryptography and Security · Computer Science 2020-10-13 David Byrd , Antigoni Polychroniadou

Federated causal inference enables multi-site treatment effect estimation without sharing individual-level data, offering a privacy-preserving solution for real-world evidence generation. However, data heterogeneity across sites, manifested…

Machine Learning · Computer Science 2025-05-06 Haoyang Li , Jie Xu , Kyra Gan , Fei Wang , Chengxi Zang

Machine learning models used for distributed architectures consisting of servers and clients require large amounts of data to achieve high accuracy. Data obtained from clients are collected on a central server for model training. However,…

Cryptography and Security · Computer Science 2025-09-18 Ozer Ozturk , Busra Buyuktanir , Gozde Karatas Baydogmus , Kazim Yildiz

Early outbreak data analysis is critical for informing about their potential impact and interventions. However, data obtained early in outbreaks are often sensitive and subject to strict privacy restrictions. Thus, federated analysis, which…

Applications · Statistics 2026-01-27 Simon Busch-Moreno , Moritz U. G. Kraemer

Learning from the collective knowledge of data dispersed across private sources can provide neural networks with enhanced generalization capabilities. Federated learning, a method for collaboratively training a machine learning model across…

Machine Learning · Computer Science 2024-05-20 Matt Gorbett , Hossein Shirazi , Indrakshi Ray

Nowadays, the utilization of the ever expanding amount of data has made a huge impact on web technologies while also causing various types of security concerns. On one hand, potential gains are highly anticipated if different organizations…

Machine Learning · Computer Science 2020-04-13 Chaochao Chen , Liang Li , Wenjing Fang , Jun Zhou , Li Wang , Lei Wang , Shuang Yang , Alex Liu , Hao Wang

Motivated by two case studies using primary care records from the Clinical Practice Research Datalink, we describe statistical methods that facilitate the analysis of tall data, with very large numbers of observations. Our focus is on…

Methodology · Statistics 2018-05-14 Kirsty Rhodes , Rebecca Turner , Rupert Payne , Ian White

Federated learning enables multiple institutions to collaboratively train machine learning models on their local data in a privacy-preserving way. However, its distributed nature often leads to significant heterogeneity in data…

Machine Learning · Computer Science 2021-07-20 Liangqiong Qu , Niranjan Balachandar , Daniel L Rubin

In federated learning, clients share a global model that has been trained on decentralized local client data. Although federated learning shows significant promise as a key approach when data cannot be shared or centralized, current methods…

Machine Learning · Computer Science 2021-02-09 Edvin Listo Zec , Olof Mogren , John Martinsson , Leon René Sütfeld , Daniel Gillblad

Federated learning (FL) is a distributed machine learning technique designed to preserve data privacy and security, and it has gained significant importance due to its broad range of applications. This paper addresses the problem of optimal…

Statistics Theory · Mathematics 2025-01-16 Tony Cai , Abhinav Chakraborty , Lasse Vuursteen

In causal inference, it is common to estimate the causal effect of a single treatment variable on an outcome. However, practitioners may also be interested in the effect of simultaneous interventions on multiple covariates of a fixed target…

Methodology · Statistics 2022-11-24 Jaime Roquero Gimenez , Dominik Rothenhäusler

This work focuses on the question of learning from a large number of devices with each device holding only a single sample of data. Several real-world applications exist to this one sample per client setup up including learning from fitness…

Machine Learning · Computer Science 2026-05-26 Praneeth Vepakomma , Amirhossein Reisizadeh , Samuel Horváth , Munther A. Dahleh

Due to the privacy protection or the difficulty of data collection, we cannot observe individual outputs for each instance, but we can observe aggregated outputs that are summed over multiple instances in a set in some real-world…

Machine Learning · Statistics 2022-10-05 Tomoharu Iwata

Federated learning allows multiple users to collaboratively train a shared classification model while preserving data privacy. This approach, where model updates are aggregated by a central server, was shown to be vulnerable to poisoning…

Machine Learning · Computer Science 2020-12-17 Chien-Lun Chen , Leana Golubchik , Marco Paolieri

Federated Learning (FL) makes a large amount of edge computing devices (e.g., mobile phones) jointly learn a global model without data sharing. In FL, data are generated in a decentralized manner with high heterogeneity. This paper studies…

Machine Learning · Statistics 2021-12-20 Xiang Li , Jiadong Liang , Xiangyu Chang , Zhihua Zhang

Data analysis based on information from several sources is common in economic and biomedical studies. This setting is often referred to as the data fusion problem, which differs from traditional missing data problems since no complete data…

Methodology · Statistics 2022-04-07 Wei Li , Shanshan Luo , Wangli Xu
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