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Reducing the cost of sequencing genomes provided by next-generation sequencing technologies has greatly increased the number of genomic projects. As a result, there is a growing need for better assembly and assembly validation methods. One…

Genomics · Quantitative Biology 2022-10-17 Przemysław Stawczyk , Robert Nowak

Developing kernels for Processing-In-Memory (PIM) platforms poses unique challenges in data management and parallel programming on limited processing units. Although software development kits (SDKs) for PIM, such as the UPMEM SDK, provide…

Hardware Architecture · Computer Science 2025-10-21 Krystian Chmielewski , Jarosław Ławnicki , Uladzislau Lukyanau , Tadeusz Kobus , Maciej Maciejewski

As its core computation, a self-attention mechanism gauges pairwise correlations across the entire input sequence. Despite favorable performance, calculating pairwise correlations is prohibitively costly. While recent work has shown the…

Machine Learning · Computer Science 2022-09-02 Amir Yazdanbakhsh , Ashkan Moradifirouzabadi , Zheng Li , Mingu Kang

Power consumption has become the major concern in neural network accelerators for edge devices. The novel non-volatile-memory (NVM) based computing-in-memory (CIM) architecture has shown great potential for better energy efficiency.…

Systems and Control · Electrical Eng. & Systems 2024-02-22 Haobo Liu , Zhengyang Qian , Wei Wu , Hongwei Ren , Zhiwei Liu , Leibin Ni

Currently, third-generation sequencing techniques, which allow to obtain much longer DNA reads compared to the next-generation sequencing technologies, are becoming more and more popular. There are many possibilities to combine data from…

Genomics · Quantitative Biology 2019-05-23 Wiktor Kuśmirek , Wiktor Franus , Robert Nowak

Triangle counting (TC) is a fundamental problem in graph analysis and has found numerous applications, which motivates many TC acceleration solutions in the traditional computing platforms like GPU and FPGA. However, these approaches suffer…

Hardware Architecture · Computer Science 2020-07-22 Xueyan Wang , Jianlei Yang , Yinglin Zhao , Yingjie Qi , Meichen Liu , Xingzhou Cheng , Xiaotao Jia , Xiaoming Chen , Gang Qu , Weisheng Zhao

The continually increasing volume of DNA sequence data has resulted in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments between candidate haplotypes and sequencing reads using Pair-HMMs is a…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-27 Bertil Schmidt , Felix Kallenborn , Alexander Wichmann , Alejandro Chacon , Christian Hundt

Accelerating finite automata processing is critical for advancing real-time analytic in pattern matching, data mining, bioinformatics, intrusion detection, and machine learning. Recent in-memory automata accelerators leveraging SRAMs and…

Hardware Architecture · Computer Science 2021-12-02 Yi Huang , Zhiyu Chen , Dai Li , Kaiyuan Yang

Motivation: Protein-to-genome alignment is critical to annotating genes in non-model organisms. While there are a few tools for this purpose, all of them were developed over ten years ago and did not incorporate the latest advances in…

Genomics · Quantitative Biology 2022-12-29 Heng Li

Modern transformer-based Large Language Models (LLMs) are constructed with a series of decoder blocks. Each block comprises three key components: (1) QKV generation, (2) multi-head attention, and (3) feed-forward networks. In batched…

Hardware Architecture · Computer Science 2024-06-21 Guseul Heo , Sangyeop Lee , Jaehong Cho , Hyunmin Choi , Sanghyeon Lee , Hyungkyu Ham , Gwangsun Kim , Divya Mahajan , Jongse Park

Database applications are increasingly bottlenecked by memory bandwidth and latency due to the memory wall and the limited scalability of DRAM. Join queries, central to analytical workloads, require intensive memory access and are…

Hardware Architecture · Computer Science 2025-08-13 Sabiha Tajdari , Anastasia Ailamaki , Sandhya Dwarkadas

Technologies for sequencing (reading) and synthesizing (writing) DNA have progressed on a Moore's law-like trajectory over the last three decades. This has motivated the idea of using DNA for data storage. Theoretically, DNA-based storage…

Emerging Technologies · Computer Science 2023-07-07 Ajay Manicka , Andrew Stephan , Sriram Chari , Gemma Mendonsa , Peyton Okubo , John Stolzberg-Schray , Anil Reddy , Marc Riedel

PIM architectures aim to reduce data transfer costs between processors and memory by integrating processing units within memory layers. Prior PIM architectures have shown potential to improve energy efficiency and performance. However, such…

Hardware Architecture · Computer Science 2025-10-10 Parker Hao Tian , Zahra Yousefijamarani , Alaa Alameldeen

Deep learning hardware designs have been bottlenecked by conventional memories such as SRAM due to density, leakage and parallel computing challenges. Resistive devices can address the density and volatility issues, but have been limited by…

Emerging Technologies · Computer Science 2020-10-28 Shihui Yin , Xiaoyu Sun , Shimeng Yu , Jae-sun Seo

The content-agnostic, fixed-grid tokenizers used by standard large-scale vision models like Vision Transformer (ViT) and Vision Mamba (Vim) represent a fundamental performance bottleneck, creating a trade-off between capturing fine-grained…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Shicheng Yin , Kaixuan Yin , Yang Liu , Weixing Chen , Liang Lin

This paper evaluates the efficacy of recent commercial processing-in-memory (PIM) solutions to accelerate fast Fourier transform (FFT), an important primitive across several domains. Specifically, we observe that efficient implementations…

Hardware Architecture · Computer Science 2023-08-09 Mohamed Assem Ibrahim , Shaizeen Aga

Processing-using-memory (PuM) techniques leverage the analog operation of memory cells to perform computation. Several recent works have demonstrated PuM techniques in off-the-shelf DRAM devices. Since DRAM is the dominant memory technology…

Hardware Architecture · Computer Science 2023-09-06 Ataberk Olgun , Juan Gómez Luna , Konstantinos Kanellopoulos , Behzad Salami , Hasan Hassan , Oğuz Ergin , Onur Mutlu

The widespread adoption of Large Language Models (LLMs) has exponentially increased the demand for efficient serving systems. With growing requests and context lengths, key-value (KV)-related operations, including attention computation and…

Hardware Architecture · Computer Science 2026-02-13 Lian Liu , Shixin Zhao , Yutian Zhou , Yintao He , Mengdi Wang , Yinhe Han , Ying Wang

As deep learning models continue to increase in size, the memory requirements for training have surged. While high-level techniques like offloading, recomputation, and compression can alleviate memory pressure, they also introduce…

Machine Learning · Computer Science 2023-10-31 Huiyao Shu , Ang Wang , Ziji Shi , Hanyu Zhao , Yong Li , Lu Lu

Transformers have emerged as a powerful tool for natural language processing (NLP) and computer vision. Through the attention mechanism, these models have exhibited remarkable performance gains when compared to conventional approaches like…

Hardware Architecture · Computer Science 2024-07-18 Salma Afifi , Ishan Thakkar , Sudeep Pasricha
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