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Composition is a powerful principle for systems biology, focused on the interfaces, interconnections, and orchestration of distributed processes to enable integrative multiscale simulations. Whereas traditional models focus on the structure…
Basic problems in complex systems are surveyed in connection with Life. As a key issue for complex systems, complementarity between syntax/rule/parts and semantics/behavior/whole is stressed. To address the issue, a constructive approach…
Modeling environmental ecosystems is essential for effective resource management, sustainable development, and understanding complex ecological processes. However, traditional data-driven methods face challenges in capturing inherently…
In this short review, I will summarize my research experience in three fields in applied mathematics: mathematical biology, applied probability, and applied discrete mathematics. Specifically, I will show how each project was initiated, and…
Science laboratory automation enables accelerated discovery in life sciences and materials. However, it requires interdisciplinary collaboration to address challenges such as robust and flexible autonomy, reproducibility, throughput,…
Robophysics investigates the physical principles that govern living-like robots operating in complex, realworld environments. Despite remarkable technological advances, robots continue to face fundamental efficiency limitations. At the…
The development of complex multicellular organisms from a single parent cell is a highly orchestrated process that cells conduct collectively without central guidance, creating intricate dynamic patterns essential for development and…
Measurement in biological systems became a subject of concern as a consequence of numerous reports on limited reproducibility of experimental results. To reveal origins of this inconsistency, we have examined general features of biological…
Leadership plays a key role in social animals, including humans, decision-making and coalescence in coordinated activities such as hunting, migration, sport, diplomatic negotiation etc. In these coordinated activities, leadership is a…
"All men by nature desire to know," states Aristotle in the famous first sentence of his Metaphysics. Knowledge about fundamental particles and interactions, that is, knowledge about the deepest aspects of matter, is certainly high if not…
Fully assessing the robustness of a software application in-house is infeasible, especially considering the huge variety of hardly predictable stimuli, environments, and configurations that applications must handle in the field. For this…
Scientific workflows consist of thousands of highly parallelized tasks executed in a distributed environment involving many components. Automatic tracing and investigation of the components' and tasks' performance metrics, traces, and…
The study of origins of life on Earth and the search for life on other planets are closely linked. Prebiotic chemical scenarios can help prioritize planets as targets for the search for life as we know it and can provide informative priors…
Advances in biology have mostly relied on theories that were subsequently revised, expanded or eventually refuted using experimental and other means. Theoretical biology used to primarily provide a basis to rationally examine the frameworks…
Our binary intuitive understanding of life and lifelikeness is good enough for daily life, but not for research in the natural sciences. Here we propose an operational definition of lifeness of a particular entity as a scalar, product of…
When interacting with their software systems, users may have to deal with problems like crashes, failures, and program instability. Faulty software running in the field is not only the consequence of ineffective in-house verification and…
We offer second year students the opportunity to explore Current Topics in Biophysics in a course co-taught by a physicist and a biologist. The interdisciplinary course allows university students to engage in analytical thinking that…
This review was written for the Encyclopedia of Complexity and System Science (Springer-Verlag, Berlin, 2008), and is intended as a guide to the growing literature which approaches the phenomena of cell biology from a more theoretical point…
Machine learning is a modern approach to problem-solving and task automation. In particular, machine learning is concerned with the development and applications of algorithms that can recognize patterns in data and use them for predictive…
Cell tracking and segmentation assist biologists in extracting insights from large-scale microscopy time-lapse data. Driven by local accuracy metrics, current tracking approaches often suffer from a lack of long-term consistency and the…