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While estimation of the marginal (total) causal effect of a point exposure on an outcome is arguably the most common objective of experimental and observational studies in the health and social sciences, in recent years, investigators have…

Statistics Theory · Mathematics 2012-10-18 Eric J. Tchetgen Tchetgen , Ilya Shpitser

Intensive longitudinal data, characterized by frequent measurements across numerous time points, are increasingly common due to advances in wearable devices and mobile health technologies. We consider evaluating causal mediation pathways…

Methodology · Statistics 2025-06-26 Tianchen Qian

Mediation analysis seeks to infer how much of the effect of an exposure on an outcome can be attributed to specific pathways via intermediate variables or mediators. This requires identification of so-called path-specific effects. These…

Methodology · Statistics 2019-06-06 Johan Steen , Stijn Vansteelandt

Causal mediation analysis is an important statistical method in social and medical studies, as it can provide insights about why an intervention works and inform the development of future interventions. Currently, most causal mediation…

Methodology · Statistics 2016-01-26 Cheng Zheng , David C. Atkins , Melissa A. Lewis , Xiao-Hua Zhou

Under the environment of big data streams, it is a common situation where the variable set of a model may change according to the condition of data streams. In this paper, we propose a homogenization strategy to represent the heterogenous…

Methodology · Statistics 2021-06-25 Lin Lu , Lu Jun , Li Weiyu

Big data streams are grasping increasing attention with the development of modern science and information technology. Due to the incompatibility of limited computer memory to high volume of streaming data, real-time methods without…

Methodology · Statistics 2023-06-29 Chunbai Tao , Shanshan Wang

A/B tests serve the purpose of reliably identifying the effect of changes introduced in online services. It is common for online platforms to run a large number of simultaneous experiments by splitting incoming user traffic randomly in…

Machine Learning · Computer Science 2022-10-18 Alexander Buchholz , Vito Bellini , Giuseppe Di Benedetto , Yannik Stein , Matteo Ruffini , Fabian Moerchen

Mediation analysis seeks to understand the mechanism by which a treatment affects an outcome. Count or zero-inflated count outcome are common in many studies in which mediation analysis is of interest. For example, in dental studies,…

Methodology · Statistics 2016-07-12 Zijian Guo , Dylan S. Small , Stuart A. Gansky , Jing Cheng

Randomized A/B tests within online learning platforms represent an exciting direction in learning sciences. With minimal assumptions, they allow causal effect estimation without confounding bias and exact statistical inference even in small…

Methodology · Statistics 2023-06-13 Adam C. Sales , Ethan B. Prihar , Johann A. Gagnon-Bartsch , Neil T. Heffernan

Big data problems frequently require processing datasets in a streaming fashion, either because all data are available at once but collectively are larger than available memory or because the data intrinsically arrive one data point at a…

Computation · Statistics 2018-08-08 Andrea Giovannucci , Victor Minden , Cengiz Pehlevan , Dmitri B. Chklovskii

Many epidemiological questions concern potential interventions to alter the pathways presumed to mediate an association. For example, we consider a study that investigates the benefit of interventions in young adulthood for ameliorating the…

Methodology · Statistics 2020-07-14 Margarita Moreno-Betancur , Paul Moran , Denise Becker , George C Patton , John B Carlin

Mediation analysis has been widely used to investigate how a treatment influences an outcome through intermediate variables, known as mediators. Analyzing a mediation mechanism typically requires assessing multiple model parameters that…

Methodology · Statistics 2025-10-01 Hanying Jiang , Kris Sankaran , Yinqiu He

Traditional mediation analysis typically examines the relations among an intervention, a time-invariant mediator, and a time-invariant outcome variable. Although there may be a direct effect of the intervention on the outcome, there is a…

Applications · Statistics 2020-08-28 Xizhen Cai , Donna L. Coffman , Megan E. Piper , Runze Li

Causal mediation analysis seeks to determine whether an independent variable affects a response variable directly or whether it does so indirectly, by way of a mediator. The existing statistical tests to determine the existence of an…

Methodology · Statistics 2023-09-28 John Kidd , Dan-Yu Lin

An essential goal of program evaluation and scientific research is the investigation of causal mechanisms. Over the past several decades, causal mediation analysis has been used in medical and social sciences to decompose the treatment…

Methodology · Statistics 2016-01-15 K. C. G. Chan , K. Imai , S. C. P. Yam , Z. Zhang

Mediation analysis draws increasing attention in many scientific areas such as genomics, epidemiology and finance. In this paper, we propose new statistical inference procedures for high dimensional mediation models, in which both the…

Methodology · Statistics 2021-08-30 Xu Guo , Runze Li , Jingyuan Liu , Mudong Zeng

Mediation analysis aims to assess if, and how, a certain exposure influences an outcome of interest through intermediate variables. This problem has recently gained a surge of attention due to the tremendous need for such analyses in…

Methodology · Statistics 2023-10-19 He Yinqiu , Song Peter X. -K. , Xu Gongjun

Online sampling-supported visual analytics is increasingly important, as it allows users to explore large datasets with acceptable approximate answers at interactive rates. However, existing online spatiotemporal sampling techniques are…

Mediation analysis is widely used for investigating direct and indirect causal pathways through which an effect arises. However, many mediation analysis studies are challenged by missingness in the mediator and outcome. In general, when the…

Methodology · Statistics 2023-09-25 Shuozhi Zuo , Debashis Ghosh , Peng Ding , Fan Yang

Streaming data routinely generated by mobile phones, social networks, e-commerce, and electronic health records present new opportunities for near real-time surveillance of the impact of an intervention on an outcome of interest via causal…

Methodology · Statistics 2021-11-30 Xu Shi , Lan Luo