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Aligning large language models (LLMs) to human preferences is a crucial step in building helpful and safe AI tools, which usually involve training on supervised datasets. Popular algorithms such as Direct Preference Optimization (DPO) rely…

Computation and Language · Computer Science 2025-06-05 Honggen Zhang , Xufeng Zhao , Igor Molybog , June Zhang

Effective biomedical data integration depends on automated term normalization, the mapping of natural language biomedical terms to standardized identifiers. This linking of terms to identifiers is essential for semantic interoperability.…

Computation and Language · Computer Science 2025-10-23 Suswitha Pericharla , Daniel B. Hier , Tayo Obafemi-Ajayi

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Large Language Models (LLMs) are increasingly used to generate synthetic textual data for training smaller specialized models. However, a comparison of various generation strategies for low-resource language settings is lacking. While…

Computation and Language · Computer Science 2025-09-22 Tatiana Anikina , Jan Cegin , Jakub Simko , Simon Ostermann

Large Language Models (LLMs) have demonstrated exceptional capabilities, yet selecting the most reliable response from multiple LLMs remains a challenge, particularly in resource-constrained settings. Existing approaches often depend on…

Computation and Language · Computer Science 2025-10-06 Aakriti Agrawal , Rohith Aralikatti , Anirudh Satheesh , Souradip Chakraborty , Amrit Singh Bedi , Furong Huang

Natural language processing (NLP) in the medical domain can underperform in real-world applications involving small datasets in a non-English language with few labeled samples and imbalanced classes. There is yet no consensus on how to…

Computation and Language · Computer Science 2024-10-01 Vincent Beliveau , Helene Kaas , Martin Prener , Claes N. Ladefoged , Desmond Elliott , Gitte M. Knudsen , Lars H. Pinborg , Melanie Ganz

Large language models (LLMs) are increasingly used in social science simulations. While their performance on reasoning and optimization tasks has been extensively evaluated, less attention has been paid to their ability to simulate human…

Computational Engineering, Finance, and Science · Computer Science 2025-08-25 Yuanjun Feng , Vivek Choudhary , Yash Raj Shrestha

Large language models (LLMs) have shown considerable promise in clinical natural language processing, yet few domain-specific datasets exist to rigorously evaluate their performance on radiology tasks. In this work, we introduce an…

Computation and Language · Computer Science 2025-11-18 Namu Park , Giridhar Kaushik Ramachandran , Kevin Lybarger , Fei Xia , Ozlem Uzuner , Meliha Yetisgen , Martin Gunn

Clinical trial matching is the task of identifying trials for which patients may be potentially eligible. Typically, this task is labor-intensive and requires detailed verification of patient electronic health records (EHRs) against the…

Contemporary large language models (LLMs) may have utility for processing unstructured, narrative free-text clinical data contained in electronic health records (EHRs) -- a particularly important use-case for mental health where a majority…

Artificial Intelligence · Computer Science 2024-04-01 Niall Taylor , Andrey Kormilitzin , Isabelle Lorge , Alejo Nevado-Holgado , Dan W Joyce

Recently published work on rephrasing natural text data for pre-training LLMs has shown promising results when combining the original dataset with the synthetically rephrased data. We build upon previous work by replicating existing results…

Using large language models (LLMs) to perform natural language processing (NLP) tasks has become increasingly pervasive in recent times. The versatile nature of LLMs makes them applicable to a wide range of such tasks. While the performance…

Software Engineering · Computer Science 2026-01-12 Steven Cho , Stefano Ruberto , Valerio Terragni

Large language models (LLMs) effectively generate fluent text when the target output follows natural language patterns. However, structured prediction tasks confine the output format to a limited ontology, causing even very large models to…

Computation and Language · Computer Science 2023-10-19 Derek Chen , Celine Lee , Yunan Lu , Domenic Rosati , Zhou Yu

The integration of Large Language Models (LLMs) into healthcare holds significant potential to enhance diagnostic accuracy and support medical treatment planning. These AI-driven systems can analyze vast datasets, assisting clinicians in…

Computation and Language · Computer Science 2025-04-15 Diogo Sousa , Guilherme Barbosa , Catarina Rocha , Dulce Oliveira

This study reviewed the use of Large Language Models (LLMs) in healthcare, focusing on their training corpora, customization techniques, and evaluation metrics. A systematic search of studies from 2021 to 2024 identified 61 articles. Four…

Computation and Language · Computer Science 2025-02-18 Shuqi Yang , Mingrui Jing , Shuai Wang , Jiaxin Kou , Manfei Shi , Weijie Xing , Yan Hu , Zheng Zhu

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

Fine-tuning Large Language Models (LLMs) on specific datasets is a common practice to improve performance on target tasks. However, this performance gain often leads to overfitting, where the model becomes too specialized in either the task…

Computation and Language · Computer Science 2024-09-10 Sonam Gupta , Yatin Nandwani , Asaf Yehudai , Mayank Mishra , Gaurav Pandey , Dinesh Raghu , Sachindra Joshi

As Large Language Models (LLMs) are increasingly integrated into healthcare to address complex inquiries, ensuring their reliability remains a critical challenge. Recent studies have highlighted that generic LLMs often struggle in clinical…

Computation and Language · Computer Science 2026-04-01 Bian Sun , Zhenjian Wang , Orvill de la Torre , Zirui Wang

Machine learning practitioners often face significant challenges in formally integrating their prior knowledge and beliefs into predictive models, limiting the potential for nuanced and context-aware analyses. Moreover, the expertise needed…

Machine Learning · Statistics 2024-12-23 James Requeima , John Bronskill , Dami Choi , Richard E. Turner , David Duvenaud

As Large Language Models (LLMs) advance in natural language processing, there is growing interest in leveraging their capabilities to simplify software interactions. In this paper, we propose a novel system that integrates LLMs for both…

Computation and Language · Computer Science 2024-09-19 Chunliang Tao , Xiaojing Fan , Yahe Yang
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