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Currently, convolutional neural networks (CNN) (e.g., U-Net) have become the de facto standard and attained immense success in medical image segmentation. However, as a downside, CNN based methods are a double-edged sword as they fail to…

Objective: Diabetic macular edema (DME) is the leading cause of severe visual impairment in patients with diabetes. Quantification of retinal fluid, particularly intraretinal fluid (IRF) and subretinal fluid (SRF), plays a critical role in…

We propose a novel deep-learning-based system for vessel segmentation. Existing methods using CNNs have mostly relied on local appearances learned on the regular image grid, without considering the graphical structure of vessel shape. To…

Vascular segmentation extracts blood vessels from images and serves as the basis for diagnosing various diseases, like ophthalmic diseases. Ophthalmologists often require high-resolution segmentation results for analysis, which leads to…

In clinical practice, regions of interest in medical imaging often need to be identified through a process of precise image segmentation. The quality of this image segmentation step critically affects the subsequent clinical assessment of…

Accurate detection of retinal vessels plays a critical role in reflecting a wide range of health status indicators in the clinical diagnosis of ocular diseases. Recently, advances in deep learning have led to a surge in retinal vessel…

Though U-Net has achieved tremendous success in medical image segmentation tasks, it lacks the ability to explicitly model long-range dependencies. Therefore, Vision Transformers have emerged as alternative segmentation structures recently,…

Significant advancements in AI-driven multimodal medical image diagnosis have led to substantial improvements in ophthalmic disease identification in recent years. However, acquiring paired multimodal ophthalmic images remains prohibitively…

Segmenting of clinically important retinal blood vessels into arteries and veins is a prerequisite for retinal vessel analysis. Such analysis can provide potential insights and bio-markers for identifying and diagnosing various retinal eye…

[Objective] This study aims to introduce a novel back projection-induced U-Net-shaped architecture, called ReconU-Net, for deep learning-based direct positron emission tomography (PET) image reconstruction. Additionally, our objective is to…

U-Net is a widely adopted neural network in the domain of medical image segmentation. Despite its quick embracement by the medical imaging community, its performance suffers on complicated datasets. The problem can be ascribed to its simple…

The accurate segmentation of retinal vessels in fundus images is a great challenge in medical image segmentation tasks due to their highly complex structure from other organs.Currently, deep-learning based methods for retinal cessel…

Retinal Vessel Segmentation is important for the diagnosis of various diseases. The research on retinal vessel segmentation focuses mainly on the improvement of the segmentation model which is usually based on U-Net architecture. In our…

The analysis of fundus images is critical for the early detection and diagnosis of retinal diseases such as Diabetic Retinopathy (DR), Glaucoma, and Age-related Macular Degeneration (AMD). Traditional diagnostic workflows, however, often…

Medical image segmentation plays an essential role in developing computer-assisted diagnosis and therapy systems, yet still faces many challenges. In the past few years, the popular encoder-decoder architectures based on CNNs (e.g., U-Net)…

Accurate segmentation of organ at risk (OAR) play a critical role in the treatment planning of image guided radiation treatment of head and neck cancer. This segmentation task is challenging for both human and automatic algorithms because…

Clinically, the accurate annotation of lesions/tissues can significantly facilitate the disease diagnosis. For example, the segmentation of optic disc/cup (OD/OC) on fundus image would facilitate the glaucoma diagnosis, the segmentation of…

Skip connection engineering is primarily employed to address the semantic gap between the encoder and decoder, while also integrating global dependencies to understand the relationships among complex anatomical structures in medical image…

Low-dose computed tomography (LDCT) has become the technology of choice for diagnostic medical imaging, given its lower radiation dose compared to standard CT, despite increasing image noise and potentially affecting diagnostic accuracy. To…

The change of retinal vasculature is an early sign of many vascular and systematic diseases, such as diabetes and hypertension. Different behaviors of retinal arterioles and venules form an important metric to measure the disease severity.…