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In-context learning has become an important approach for few-shot learning in Large Language Models because of its ability to rapidly adapt to new tasks without fine-tuning model parameters. However, it is restricted to applications in…

Machine Learning · Computer Science 2023-10-16 Christopher Fifty , Jure Leskovec , Sebastian Thrun

Few-shot molecular property prediction (FSMPP) is essential in drug discovery and materials design, where high-quality labeled data are often scarce and expensive to obtain. Despite the promising performance of existing methods, especially…

Computational Engineering, Finance, and Science · Computer Science 2026-05-14 Zeyu Wang , Xin Zheng , Yao Lu , Shanqing Yu , Qi Xuan , Shirui Pan

Molecular property prediction (MPP) is a cornerstone of drug discovery and materials science, yet conventional deep learning approaches depend on large labeled datasets that are often unavailable. Few-shot Molecular property prediction…

Machine Learning · Computer Science 2025-10-27 Xiangyang Xu , Hongyang Gao

AI-assisted molecular property prediction has become a promising technique in early-stage drug discovery and materials design in recent years. However, due to high-cost and complex wet-lab experiments, real-world molecules usually…

Computational Engineering, Finance, and Science · Computer Science 2025-10-13 Zeyu Wang , Tianyi Jiang , Huanchang Ma , Yao Lu , Xiaoze Bao , Shanqing Yu , Qi Xuan , Shirui Pan , Xin Zheng

Few-shot, fine-grained classification in computer vision poses significant challenges due to the need to differentiate subtle class distinctions with limited data. This paper presents a novel method that enhances the Contrastive…

Computer Vision and Pattern Recognition · Computer Science 2025-04-24 Eric Brouwer , Jan Erik van Woerden , Gertjan Burghouts , Matias Valdenegro-Toro , Marco Zullich

Molecular property prediction (MPP) plays a crucial role in biomedical applications, but it often encounters challenges due to a scarcity of labeled data. Existing works commonly adopt gradient-based strategy to update a large amount of…

Machine Learning · Computer Science 2024-10-16 Shiguang Wu , Yaqing Wang , Quanming Yao

We introduce Scaffold Prompt Tuning (ScaPT), a novel prompt-based framework for adapting large-scale functional magnetic resonance imaging (fMRI) pre-trained models to downstream tasks, with high parameter efficiency and improved…

Neurons and Cognition · Quantitative Biology 2024-08-21 Zijian Dong , Yilei Wu , Zijiao Chen , Yichi Zhang , Yueming Jin , Juan Helen Zhou

Prompt-based fine-tuning has boosted the performance of Pre-trained Language Models (PLMs) on few-shot text classification by employing task-specific prompts. Yet, PLMs are unfamiliar with prompt-style expressions during pre-training, which…

Computation and Language · Computer Science 2022-05-12 Jianing Wang , Chengyu Wang , Fuli Luo , Chuanqi Tan , Minghui Qiu , Fei Yang , Qiuhui Shi , Songfang Huang , Ming Gao

Molecular property prediction (MPP) is a fundamental and crucial task in drug discovery. However, prior methods are limited by the requirement for a large number of labeled molecules and their restricted ability to generalize for unseen and…

Quantitative Methods · Quantitative Biology 2024-10-21 Yuyan Liu , Sirui Ding , Sheng Zhou , Wenqi Fan , Qiaoyu Tan

Few-shot learning is a promising approach to molecular property prediction as supervised data is often very limited. However, many important molecular properties depend on complex molecular characteristics -- such as the various 3D…

Machine Learning · Computer Science 2023-10-10 Christopher Fifty , Joseph M. Paggi , Ehsan Amid , Jure Leskovec , Ron Dror

Prompt-based methods have achieved promising results in most few-shot text classification tasks. However, for readability assessment tasks, traditional prompt methods lackcrucial linguistic knowledge, which has already been proven to be…

Computation and Language · Computer Science 2024-04-11 Ziyang Wang , Sanwoo Lee , Hsiu-Yuan Huang , Yunfang Wu

When adapting large language models (LLMs) to a specific downstream task, two primary approaches are commonly employed: (1) prompt engineering, often with in-context few-shot learning, leveraging the model's inherent generalization…

Machine Learning · Computer Science 2025-12-24 Jorg Bornschein , Clare Lyle , Yazhe Li , Amal Rannen-Triki , Xu Owen He , Razvan Pascanu

In this paper, we look at cross-domain few-shot classification which presents the challenging task of learning new classes in previously unseen domains with few labelled examples. Existing methods, though somewhat effective, encounter…

Computer Vision and Pattern Recognition · Computer Science 2024-04-04 Rashindrie Perera , Saman Halgamuge

Vision-language models have recently shown great potential on many tasks in computer vision. Meanwhile, prior work demonstrates prompt tuning designed for vision-language models could acquire superior performance on few-shot image…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Kun Ding , Ying Wang , Pengzhang Liu , Qiang Yu , Haojian Zhang , Shiming Xiang , Chunhong Pan

Visual Prompt Tuning (VPT) of pre-trained Vision Transformers (ViTs) has proven highly effective as a parameter-efficient fine-tuning technique for adapting large models to downstream tasks with limited data. Its parameter efficiency makes…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 M Yashwanth , Sharannya Ghosh , Aditay Tripathi , Anirban Chakraborty

Predicting transcriptional responses to novel drugs provides a unique opportunity to accelerate biomedical research and advance drug discovery efforts. However, the inherent complexity and high dimensionality of cellular responses, combined…

We introduce Context Tuning, a simple and effective method to significantly enhance few-shot adaptation of language models (LLMs) without fine-tuning model parameters. While prompt-based adaptation techniques have demonstrated the…

Computation and Language · Computer Science 2025-11-04 Jack Lu , Ryan Teehan , Zhenbang Yang , Mengye Ren

Pre-trained language models (PLMs) have exhibited remarkable few-shot learning capabilities when provided a few examples in a natural language prompt as demonstrations of test instances, i.e., in-context learning. However, the performance…

Computation and Language · Computer Science 2022-12-06 Feng Nie , Meixi Chen , Zhirui Zhang , Xu Cheng

Large-scale pre-trained models have achieved remarkable success in language and image tasks, leading an increasing number of studies to explore the application of pre-trained image models, such as CLIP, in the domain of few-shot action…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Congqi Cao , Peiheng Han , Yueran zhang , Yating Yu , Qinyi Lv , Lingtong Min , Yanning zhang

Prompt tuning is a parameter-efficient approach to adapting pre-trained language models to downstream tasks. Although prompt tuning has been shown to match the performance of full model tuning when training data is sufficient, it tends to…

Computation and Language · Computer Science 2023-05-09 Tianxiang Sun , Zhengfu He , Qin Zhu , Xipeng Qiu , Xuanjing Huang
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