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The prediction modeling of drug-target interactions is crucial to drug discovery and design, which has seen rapid advancements owing to deep learning technologies. Recently developed methods, such as those based on graph neural networks…

Quantitative Methods · Quantitative Biology 2025-11-19 Xinnan Zhang , Jialin Wu , Junyi Xie , Tianlong Chen , Kaixiong Zhou

Graph neural networks (GNNs) provide powerful insights for brain neuroimaging technology from the view of graphical networks. However, most existing GNN-based models assume that the neuroimaging-produced brain connectome network is a…

Machine Learning · Computer Science 2022-09-30 Gen Shi , Yifan Zhu , Wenjin Liu , Quanming Yao , Xuesong Li

In this research, we present our work participation for the DrugProt task of BioCreative VII challenge. Drug-target interactions (DTIs) are critical for drug discovery and repurposing, which are often manually extracted from the…

Computation and Language · Computer Science 2021-11-09 Jehad Aldahdooh , Ziaurrehman Tanoli , Jing Tang

Massive social media data can reflect people's authentic thoughts, emotions, communication, etc., and therefore can be analyzed for early detection of mental health problems such as depression. Existing works about early depression…

Social and Information Networks · Computer Science 2025-03-04 Chen Chen , Mingwei Li , Fenghuan Li , Haopeng Chen , Yuankun Lin

Drug discovery remains a slow and expensive process that involves many steps, from detecting the target structure to obtaining approval from the Food and Drug Administration (FDA), and is often riddled with safety concerns. Accurate…

Quantitative Methods · Quantitative Biology 2025-08-22 Ali Vefghi , Zahed Rahmati , Mohammad Akbari

Graph representation learning has attracted a surge of interest recently, whose target at learning discriminant embedding for each node in the graph. Most of these representation methods focus on supervised learning and heavily depend on…

Machine Learning · Computer Science 2021-07-07 Pengpeng Shao , Tong Liu , Dawei Zhang , Jianhua Tao , Feihu Che , Guohua Yang

Trapped by the label scarcity in molecular property prediction and drug design, graph contrastive learning (GCL) came forward. Leading contrastive learning works show two kinds of view generators, that is, random or learnable data…

Machine Learning · Computer Science 2025-01-16 Xueyuan Chen , Shangzhe Li , Ruomei Liu , Bowen Shi , Jiaheng Liu , Junran Wu , Ke Xu

Graph contrastive learning (GCL) has recently emerged as a new concept which allows for capitalizing on the strengths of graph neural networks (GNNs) to learn rich representations in a wide variety of applications which involve abundant…

Machine Learning · Computer Science 2024-06-26 Yuzhou Chen , Jose Frias , Yulia R. Gel

Graph Contrastive Learning (GCL), which fuses graph neural networks with contrastive learning, has evolved as a pivotal tool in user-item recommendations. While promising, existing GCL methods often lack explicit modeling of hierarchical…

Information Retrieval · Computer Science 2025-05-27 Jiawei Xue , Zhen Yang , Haitao Lin , Ziji Zhang , Luzhu Wang , Yikun Gu , Yao Xu , Xin Li

Hypergraphs provide a superior modeling framework for representing complex multidimensional relationships in the context of real-world interactions that often occur in groups, overcoming the limitations of traditional homogeneous graphs.…

Machine Learning · Computer Science 2025-02-13 Daeyoung Roh , Donghee Han , Daehee Kim , Keejun Han , Mun Yi

Graph Convolutional Networks (GCNs) are predominantly tailored for graphs displaying homophily, where similar nodes connect, but often fail on heterophilic graphs. The strategy of adopting distinct approaches to learn from homophilic and…

Machine Learning · Computer Science 2025-04-09 Han Lei , Jiaxing Xu , Xia Dong , Yiping Ke

Various graph contrastive learning models have been proposed to improve the performance of learning tasks on graph datasets in recent years. While effective and prevalent, these models are usually carefully customized. In particular,…

Machine Learning · Computer Science 2021-11-01 Dongkuan Xu , Wei Cheng , Dongsheng Luo , Haifeng Chen , Xiang Zhang

Complex or co-existing diseases are commonly treated using drug combinations, which can lead to higher risk of adverse side effects. The detection of polypharmacy side effects is usually done in Phase IV clinical trials, but there are still…

Machine Learning · Statistics 2019-05-03 Andreea Deac , Yu-Hsiang Huang , Petar Veličković , Pietro Liò , Jian Tang

The joint hyperspectral image (HSI) and LiDAR data classification aims to interpret ground objects at more detailed and precise level. Although deep learning methods have shown remarkable success in the multisource data classification task,…

Image and Video Processing · Electrical Eng. & Systems 2023-02-08 Meng Wang , Feng Gao , Junyu Dong , Heng-Chao Li , Qian Du

Graph contrastive learning (GCL) aims to learn discriminative semantic invariance by contrasting different views of the same graph that share critical topological patterns. However, existing GCL approaches with structural augmentations…

Machine Learning · Computer Science 2025-12-03 Qirui Ji , Bin Qin , Yifan Jin , Yunze Zhao , Chuxiong Sun , Changwen Zheng , Jianwen Cao , Jiangmeng Li

Foundation models have achieved great success in natural language processing (NLP) and computer vision (CV). Their success largely stems from the ability to integrate multi-domain knowledge in pre-training and transfer it to target domains.…

Computation and Language · Computer Science 2025-07-01 Zihao Zhao , Xinlong Zhai , Jinyu Yang , Chuan Shi

Scene Graph Generation (SGG) as a critical task in image understanding, facing the challenge of head-biased prediction caused by the long-tail distribution of predicates. However, current unbiased SGG methods can easily prioritize improving…

Computer Vision and Pattern Recognition · Computer Science 2023-08-24 Lei Wang , Zejian Yuan , Yao Lu , Badong Chen

Preventable adverse drug reactions as a result of medical errors present a growing concern in modern medicine. As drug-drug interactions (DDIs) may cause adverse reactions, being able to extracting DDIs from drug labels into…

Computation and Language · Computer Science 2019-05-21 Tung Tran , Ramakanth Kavuluru , Halil Kilicoglu

Drug-target interaction is fundamental in understanding how drugs affect biological systems, and accurately predicting drug-target affinity (DTA) is vital for drug discovery. Recently, deep learning methods have emerged as a significant…

Machine Learning · Computer Science 2024-12-30 Minghui Li , Zikang Guo , Yang Wu , Peijin Guo , Yao Shi , Shengshan Hu , Wei Wan , Shengqing Hu

Rating is a typical user explicit feedback that visually reflects how much a user likes a related item. The (rating) matrix completion is essentially a rating prediction process, which is also a significant problem in recommender systems.…

Machine Learning · Computer Science 2025-07-09 Xiang Li , Changsheng Shui , Zhongying Zhao , Junyu Dong , Yanwei Yu
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