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Biomedical networks (or graphs) are universal descriptors for systems of interacting elements, from molecular interactions and disease co-morbidity to healthcare systems and scientific knowledge. Advances in artificial intelligence,…

Machine Learning · Computer Science 2025-02-07 Michelle M. Li , Kexin Huang , Marinka Zitnik

Climate change is reshaping species interactions and movement across fragmented landscapes. Despite this, most mathematical models assume random diffusion, overlooking the influence of directed movement. Here, we develop a graph based…

Dynamical Systems · Mathematics 2026-04-08 Pranali Roy Chowdhury , Soumyendu Raha

Cardiovascular networks span the body by branching across many generations of vessels. The resulting structure delivers blood over long distances to supply all cells with oxygen via the relatively short-range process of diffusion at the…

Medical Physics · Physics 2016-06-15 David Hunt , Van M. Savage

Branched Optimal Transport (BOT) is a generalization of optimal transport in which transportation costs along an edge are subadditive. This subadditivity models an increase in transport efficiency when shipping mass along the same route,…

Machine Learning · Computer Science 2022-10-17 Peter Lippmann , Enrique Fita Sanmartín , Fred A. Hamprecht

Unlike many physical nonequilibrium systems, in biological systems, the coupling to external energy sources is not a fixed parameter but adaptively controlled by the system itself. We do not have theoretical frameworks that allow for such…

Populations and Evolution · Quantitative Biology 2025-06-30 Ankit Dhanuka , Avi I. Flamholz , Arvind Murugan , Akshit Goyal

We study spatial networks that are designed to distribute or collect a commodity, such as gas pipelines or train tracks. We focus on the cost of a network, as represented by the total length of all its edges, and its efficiency in terms of…

Disordered Systems and Neural Networks · Physics 2007-05-23 Michael T. Gastner , M. E. J. Newman

Constraints placed upon the phenotypes of organisms result from their interactions with the environment. Over evolutionary timescales, these constraints feed back onto smaller molecular subnetworks comprising the organism. The evolution of…

Molecular Networks · Quantitative Biology 2015-06-10 Cameron Smith , Ximo Pechuan , Raymond S. Puzio , Daniel Biro , Aviv Bergman

The plant hormone auxin controls many aspects of the development of plants. One striking dynamical feature is the self-organisation of leaf venation patterns which is driven by high levels of auxin within vein cells. The auxin transport is…

Dynamical Systems · Mathematics 2019-12-20 Jan Haskovec , Henrik Jönsson , Lisa Maria Kreusser , Peter Markowich

Adaptive networks have been recently introduced in the context of disease propagation on complex networks. They account for the mutual interaction between the network topology and the states of the nodes. Until now, existing models have…

Statistical Mechanics · Physics 2010-09-28 Vincent Marceau , Pierre-André Noël , Laurent Hébert-Dufresne , Antoine Allard , Louis J. Dubé

Network embedding has recently emerged as a promising technique to embed nodes of a network into low-dimensional vectors. While fairly successful, most existing works focus on the embedding techniques for static networks. But in practice,…

Social and Information Networks · Computer Science 2020-10-28 Zenan Xu , Zijing Ou , Qinliang Su , Jianxing Yu , Xiaojun Quan , Zhenkun Lin

Optimal operation of distribution grid resources relies on accurate estimation of its state and topology. Practical estimation of such quantities is complicated by the limited presence of real-time meters. This paper discusses a theoretical…

Systems and Control · Computer Science 2020-01-06 Deepjyoti Deka , Michael Chertkov , Scott Backhaus

The relationship between network topology and system dynamics has significant implications for unifying our understanding of the interplay among metabolic, gene-regulatory, and ecosystem network architecures. Here we analyze the stability…

Populations and Evolution · Quantitative Biology 2015-06-17 Cameron Smith , Raymond S. Puzio , Aviv Bergman

A generic flow distribution network typically does not deliver its load at a uniform rate across a service area, instead oversupplying regions near the nutrient source while leaving downstream regions undersupplied. In this work we…

Biological Physics · Physics 2021-09-06 Tatyana Gavrilchenko , Eleni Katifori

The model by Hu and Cai [Phys. Rev. Lett., Vol. 111(13) (2013)] describes the self-organization of vascular networks for transport of fluids from source to sinks. Diameters, and thereby conductances, of vessel segments evolve so as to…

Adaptation and Self-Organizing Systems · Physics 2024-11-20 Konstantin Klemm , Erik Andreas Martens

Flux of rigid or soft particles (such as drops, vesicles, red blood cells, etc.) in a channel is a complex function of particle concentration, which depends on the details of induced dissipation and suspension structure due to hydrodynamic…

Accurately determining and classifying the structure of complex networks is the focus of much current research. One class of network of particular interest are metabolic pathways, which have previously been studied from a graph theoretical…

Mathematical Physics · Physics 2012-10-10 Henry Dorrian , Kieran Smallbone , Jon borresen

Air transport systems are highly dynamic at temporal scales from minutes to years. This dynamic behavior not only characterizes the evolution of the system but also affect the system's functioning. Understanding the evolutionary mechanisms…

Physics and Society · Physics 2016-05-17 Luis Enrique Correa Rocha

Low-dimensional vector representations of network nodes have proven successful to feed graph data to machine learning algorithms and to improve performance across diverse tasks. Most of the embedding techniques, however, have been developed…

Physics and Society · Physics 2021-05-04 Koya Sato , Mizuki Oka , Alain Barrat , Ciro Cattuto

Liquid water, besides being fundamental for life on Earth, has long fascinated scientists due to several anomalies. Different hypotheses have been put forward to explain these peculiarities. The most accredited one foresees the presence in…

Numerical Analysis · Mathematics 2022-10-26 Michele Benzi , Isabella Daidone , Chiara Faccio , Laura Zanetti-Polzi

Complex networks characterized by global transport processes rely on the presence of directed paths from input to output nodes and edges, which organize in characteristic linked components. The analysis of such network-spanning structures…

Disordered Systems and Neural Networks · Physics 2015-05-13 M. Angeles Serrano , Paolo De Los Rios