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Large Language Models (LLMs) have shown promising performance on diverse medical benchmarks, highlighting their potential in supporting real-world clinical tasks. Retrieval-Augmented Generation (RAG) has emerged as a key approach for…

Computation and Language · Computer Science 2025-09-30 Kaishuai Xu , Wenjun Hou , Yi Cheng , Wenjie Li

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

Retrieval-Augmented Generation (RAG) has been shown to enhance the factual accuracy of Large Language Models (LLMs), but existing methods often suffer from limited reasoning capabilities in effectively using the retrieved evidence,…

Computation and Language · Computer Science 2024-10-03 Shayekh Bin Islam , Md Asib Rahman , K S M Tozammel Hossain , Enamul Hoque , Shafiq Joty , Md Rizwan Parvez

Large Language Models (LLMs) showcase impressive capabilities but encounter challenges like hallucination, outdated knowledge, and non-transparent, untraceable reasoning processes. Retrieval-Augmented Generation (RAG) has emerged as a…

Computation and Language · Computer Science 2024-03-28 Yunfan Gao , Yun Xiong , Xinyu Gao , Kangxiang Jia , Jinliu Pan , Yuxi Bi , Yi Dai , Jiawei Sun , Meng Wang , Haofen Wang

Retrieval-augmented generation (RAG) has emerged as an approach to augment large language models (LLMs) by reducing their reliance on static knowledge and improving answer factuality. RAG retrieves relevant context snippets and generates an…

Computation and Language · Computer Science 2025-02-21 Juraj Vladika , Florian Matthes

Despite the potential of Large Language Models (LLMs) in medicine, they may generate responses lacking supporting evidence or based on hallucinated evidence. While Retrieval Augment Generation (RAG) is popular to address this issue, few…

Large Language Models (LLMs) exhibit remarkable capabilities but are prone to generating inaccurate or hallucinatory responses. This limitation stems from their reliance on vast pretraining datasets, making them susceptible to errors in…

Computation and Language · Computer Science 2024-04-02 Chi-Min Chan , Chunpu Xu , Ruibin Yuan , Hongyin Luo , Wei Xue , Yike Guo , Jie Fu

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Large Language Models (LLMs) have enabled a wide range of applications through their powerful capabilities in language understanding and generation. However, as LLMs are trained on static corpora, they face difficulties in addressing…

Computation and Language · Computer Science 2025-10-13 Yongjie Wang , Yue Yu , Kaisong Song , Jun Lin , Zhiqi Shen

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

This paper presents the development and evaluation of a Retrieval-Augmented Generation (RAG) system for querying the United Kingdom's National Institute for Health and Care Excellence (NICE) clinical guidelines using Large Language Models…

As one of the most advanced techniques in AI, Retrieval-Augmented Generation (RAG) can offer reliable and up-to-date external knowledge, providing huge convenience for numerous tasks. Particularly in the era of AI-Generated Content (AIGC),…

Computation and Language · Computer Science 2024-06-18 Wenqi Fan , Yujuan Ding , Liangbo Ning , Shijie Wang , Hengyun Li , Dawei Yin , Tat-Seng Chua , Qing Li

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Retrieval augmented generation (RAG) has been applied in many scenarios to augment large language models (LLMs) with external documents provided by retrievers. However, a semantic gap exists between LLMs and retrievers due to differences in…

Computation and Language · Computer Science 2024-10-31 Fuda Ye , Shuangyin Li , Yongqi Zhang , Lei Chen

Retrieval augmented generation (RAG) systems provide a method for factually grounding the responses of a Large Language Model (LLM) by providing retrieved evidence, or context, as support. Guided by this context, RAG systems can reduce…

Information Retrieval · Computer Science 2025-09-05 Shakiba Amirshahi , Amin Bigdeli , Charles L. A. Clarke , Amira Ghenai

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

Computation and Language · Computer Science 2024-07-09 Bojana Bašaragin , Adela Ljajić , Darija Medvecki , Lorenzo Cassano , Miloš Košprdić , Nikola Milošević

While large language models (LLMs) have achieved state-of-the-art performance on a wide range of medical question answering (QA) tasks, they still face challenges with hallucinations and outdated knowledge. Retrieval-augmented generation…

Computation and Language · Computer Science 2024-02-26 Guangzhi Xiong , Qiao Jin , Zhiyong Lu , Aidong Zhang

Large language models (LLMs) inevitably exhibit hallucinations since the accuracy of generated texts cannot be secured solely by the parametric knowledge they encapsulate. Although retrieval-augmented generation (RAG) is a practicable…

Computation and Language · Computer Science 2024-10-08 Shi-Qi Yan , Jia-Chen Gu , Yun Zhu , Zhen-Hua Ling
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