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Accurate prediction of crop states (e.g., phenology stages and cold hardiness) is essential for timely farm management decisions such as irrigation, fertilization, and canopy management to optimize crop yield and quality. While traditional…

Artificial Intelligence · Computer Science 2026-05-20 William Solow , Paola Pesantez-Cabrera , Markus Keller , Lav Khot , Sandhya Saisubramanian , Alan Fern

This work demonstrates the execution of a novel process model for knowledge discovery and data mining for metabolomics (MeKDDaM). It aims to illustrate MeKDDaM process model applicability using four different real-world applications and to…

Quantitative Methods · Quantitative Biology 2019-07-31 Ahmed BaniMustafa , Nigel Hardy

Hyperbolic embeddings are a class of representation learning methods that offer competitive performances when data can be abstracted as a tree-like graph. However, in practice, learning hyperbolic embeddings of hierarchical data is…

Machine Learning · Computer Science 2024-07-24 Zhangyu Wang , Lantian Xu , Zhifeng Kong , Weilong Wang , Xuyu Peng , Enyang Zheng

Motivation: Cell-biological processes are regulated through a complex network of interactions between genes and their products. The processes, their activating conditions, and the associated transcriptional responses are often unknown.…

Molecular Networks · Quantitative Biology 2012-02-03 Leo Lahti , Juha E. A. Knuuttila , Samuel Kaski

Addressing the functionality of genomes is one of the most important and challenging tasks of today's biology. In particular the ability to link genotypes to corresponding phenotypes is of interest in the reconstruction and biotechnological…

Predicting drug side-effects before they occur is a key task in keeping the number of drug-related hospitalizations low and to improve drug discovery processes. Automatic predictors of side-effects generally are not able to process the…

Machine Learning · Statistics 2022-12-01 Pietro Bongini , Elisa Messori , Niccolò Pancino , Monica Bianchini

Metabolic pathways describe chains of enzymatic reactions. Their modelling is a key point to understand living systems. An enzymatic reaction is an interaction between one or several metabolites (substrates) and an enzyme (simple protein or…

Subcellular Processes · Quantitative Biology 2009-01-27 Charles Lales , N. Parisey , Jean-Pierre Mazat , Marie Beurton-Aimar

This work explores hypernetworks: an approach of using a one network, also known as a hypernetwork, to generate the weights for another network. Hypernetworks provide an abstraction that is similar to what is found in nature: the…

Machine Learning · Computer Science 2016-12-02 David Ha , Andrew Dai , Quoc V. Le

Many methods have been developed for finding the commonalities between different organisms to study their phylogeny. The structure of metabolic networks also reveal valuable insights into metabolic capacity of species as well as into the…

Molecular Networks · Quantitative Biology 2016-04-08 Krishanu Deyasi , Anirban Banerjee , Bony Deb

13C-Metabolic Flux Analysis (13C-MFA) and Flux Balance Analysis (FBA) are widely used to investigate the operation of biochemical networks in both biological and biotechnological research. Both of these methods use metabolic reaction…

Molecular Networks · Quantitative Biology 2023-03-23 Joshua A. M. Kaste , Yair Shachar-Hill

Background: Representing biological networks as graphs is a powerful approach to reveal underlying patterns, signatures, and critical components from high-throughput biomolecular data. However, graphs do not natively capture the multi-way…

During the last two decades, we easilly see that the World Wide Web's link structure is modeled as the directed graph. In this paper, we will model the World Wide Web's link structure as the directed hypergraph. Moreover, we will develop…

Social and Information Networks · Computer Science 2022-09-07 Loc Tran , Tho Quan , An Mai

Relational data are ubiquitous in real-world data applications, e.g., in social network analysis or biological modeling, but networks are nearly always incompletely observed. The state-of-the-art for predicting missing links in the hard…

Machine Learning · Computer Science 2025-08-13 Bisman Singh , Lucy Van Kleunen , Aaron Clauset

Constraint based methods, such as the Flux Balance Analysis, are widely used to model cellular growth processes without relying on extensive information on the regulatory features. The regulation is instead substituted by an optimization…

Optimization and Control · Mathematics 2017-06-14 Henning Lindhorst , Sergio Lucia , Rolf Findeisen , Steffen Waldherr

Recent empirical evidence has shown that in many real-world systems, successfully represented as networks, interactions are not limited to dyads, but often involve three or more agents at a time. These data are better described by…

Physics and Society · Physics 2021-04-01 Federico Musciotto , Federico Battiston , Rosario N. Mantegna

Travel demand prediction is crucial for optimizing transportation planning, resource allocation, and infrastructure development, ensuring efficient mobility and economic sustainability. This study introduces a Neurosymbolic Artificial…

Machine Learning · Computer Science 2025-08-12 Kamal Acharya , Mehul Lad , Liang Sun , Houbing Song

Gene function prediction from microarray data is a first step toward better understanding the machinery of the cell from relatively cheap and easy-to-produce data. In this paper we investigate whether the knowledge of many metabolic…

Biological Physics · Physics 2007-05-23 Jean-Philippe Vert , Minoru Kanehisa

As one of the most prevalent diseases worldwide, plaque formation in human arteries, known as atherosclerosis, is the focus of many research efforts. Previously, molecular communication (MC) models have been proposed to capture and analyze…

Biomedical knowledge graphs permit an integrative computational approach to reasoning about biological systems. The nature of biological data leads to a graph structure that differs from those typically encountered in benchmarking datasets.…

Machine Learning · Computer Science 2021-03-19 Yushan Liu , Marcel Hildebrandt , Mitchell Joblin , Martin Ringsquandl , Rime Raissouni , Volker Tresp

Existing multi-relational graph neural networks use one of two strategies for identifying informative relations: either they reduce this problem to low-level weight learning, or they rely on handcrafted chains of relational dependencies,…

Machine Learning · Computer Science 2023-11-21 Francesco Ferrini , Antonio Longa , Andrea Passerini , Manfred Jaeger