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Generative diffusion models can provide powerful prior probability models for inverse problems in imaging, but existing implementations suffer from two key limitations: $(i)$ the prior density is represented implicitly, and $(ii)$ they rely…

Machine Learning · Computer Science 2026-05-19 Nicolas Zilberstein , Santiago Segarra , Eero Simoncelli , Florentin Guth

Magnetic Resonance Imaging (MRI) is a vital component of medical imaging. When compared to other image modalities, it has advantages such as the absence of radiation, superior soft tissue contrast, and complementary multiple sequence…

Image and Video Processing · Electrical Eng. & Systems 2021-05-06 Guang Yang , Jun Lv , Yutong Chen , Jiahao Huang , Jin Zhu

Recovering high-dimensional statistical structure from limited measurements is a fundamental challenge in hyperspectral imaging, where capturing full-resolution data is often infeasible due to sensor, bandwidth, or acquisition constraints.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-01 Jonathan Monsalve , Kumar Vijay Mishra

A conditional latent-diffusion based framework for solving the electromagnetic inverse scattering problem associated with microwave imaging is introduced. This generative machine-learning model explicitly mirrors the non-uniqueness of the…

Image and Video Processing · Electrical Eng. & Systems 2025-10-30 Shirin Chehelgami , Joe LoVetri , Vahab Khoshdel

Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased…

Image and Video Processing · Electrical Eng. & Systems 2023-02-07 Tiange Xiang , Mahmut Yurt , Ali B Syed , Kawin Setsompop , Akshay Chaudhari

Diffusion models have become a popular approach for image generation and reconstruction due to their numerous advantages. However, most diffusion-based inverse problem-solving methods only deal with 2D images, and even recently published 3D…

Image and Video Processing · Electrical Eng. & Systems 2023-09-04 Suhyeon Lee , Hyungjin Chung , Minyoung Park , Jonghyuk Park , Wi-Sun Ryu , Jong Chul Ye

We introduce Diffusion Active Learning, a novel approach that combines generative diffusion modeling with data-driven sequential experimental design to adaptively acquire data for inverse problems. Although broadly applicable, we focus on…

Machine Learning · Computer Science 2025-04-07 Luis Barba , Johannes Kirschner , Tomas Aidukas , Manuel Guizar-Sicairos , Benjamín Béjar

There remains an important need for the development of image reconstruction methods that can produce diagnostically useful images from undersampled measurements. In magnetic resonance imaging (MRI), for example, such methods can facilitate…

Image and Video Processing · Electrical Eng. & Systems 2021-06-28 Varun A. Kelkar , Sayantan Bhadra , Mark A. Anastasio

Diffusion MRI is a non-invasive, in-vivo biomedical imaging method for mapping tissue microstructure. Applications include structural connectivity imaging of the human brain and detecting microstructural neural changes. However, acquiring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Amir Sadikov , Xinlei Pan , Hannah Choi , Lanya T. Cai , Pratik Mukherjee

Most existing learning-based methods for solving imaging inverse problems can be roughly divided into two classes: iterative algorithms, such as plug-and-play and diffusion methods leveraging pretrained denoisers, and unrolled architectures…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Matthieu Terris , Samuel Hurault , Maxime Song , Julian Tachella

Inverse design refers to the problem of optimizing the input of an objective function in order to enact a target outcome. For many real-world engineering problems, the objective function takes the form of a simulator that predicts how the…

The CSGM framework (Bora-Jalal-Price-Dimakis'17) has shown that deep generative priors can be powerful tools for solving inverse problems. However, to date this framework has been empirically successful only on certain datasets (for…

Machine Learning · Computer Science 2021-12-07 Ajil Jalal , Marius Arvinte , Giannis Daras , Eric Price , Alexandros G. Dimakis , Jonathan I. Tamir

Diffusion generative models have emerged as a powerful framework for addressing problems in structural biology and structure-based drug design. These models operate directly on 3D molecular structures. Due to the unfavorable scaling of…

Biomolecules · Quantitative Biology 2024-05-10 Ian Dunn , David Ryan Koes

We propose in this paper an analytically new construct of a diffusion model whose drift and diffusion parameters yield an exponentially time-decaying Signal to Noise Ratio in the forward process. In reverse, the construct cleverly carries…

Image and Video Processing · Electrical Eng. & Systems 2024-08-16 Tanmay Asthana , Yufang Bao , Hamid Krim

Many interesting tasks in image restoration can be cast as linear inverse problems. A recent family of approaches for solving these problems uses stochastic algorithms that sample from the posterior distribution of natural images given the…

Image and Video Processing · Electrical Eng. & Systems 2022-10-14 Bahjat Kawar , Michael Elad , Stefano Ermon , Jiaming Song

Blind inverse problems in imaging arise from uncertainties in the system used to collect (noisy) measurements of images. Recovering clean images from these measurements typically requires identifying the imaging system, either implicitly or…

Image and Video Processing · Electrical Eng. & Systems 2025-03-28 Brett Levac , Ajil Jalal , Kannan Ramchandran , Jonathan I. Tamir

Despite the remarkable generative capabilities of diffusion models, their integration into safety-critical or scientifically rigorous applications remains hindered by the need to ensure compliance with stringent physical, structural, and…

Machine Learning · Computer Science 2025-06-03 Jacob K. Christopher , Michael Cardei , Jinhao Liang , Ferdinando Fioretto

This paper focuses on the analysis of sequential image data, particularly brain imaging data such as MRI, fMRI, CT, with the motivation of understanding the brain aging process and neurodegenerative diseases. To achieve this goal, we…

Machine Learning · Statistics 2024-07-22 Zhenghao Li , Sanyou Wu , Long Feng

Magnetic Resonance Imaging can produce detailed images of the anatomy and physiology of the human body that can assist doctors in diagnosing and treating pathologies such as tumours. However, MRI suffers from very long acquisition times…

Image and Video Processing · Electrical Eng. & Systems 2022-03-30 George Yiasemis , Jan-Jakob Sonke , Clarisa Sánchez , Jonas Teuwen

Diffusion models have emerged as powerful generative priors for solving inverse imaging problems. However, their practical deployment is hindered by the substantial computational cost of slow, multi-step sampling. Although Consistency…

Image and Video Processing · Electrical Eng. & Systems 2025-12-04 Amirreza Tanevardi , Pooria Abbas Rad Moghadam , Seyed Mohammad Eshtehardian , Sajjad Amini , Babak Khalaj