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The spatial location of cells within tissues and organs is crucial for the manifestation of their specific functions.Spatial transcriptomics technology enables comprehensive measurement of the gene expression patterns in tissues while…

Quantitative Methods · Quantitative Biology 2024-07-12 Shuailin Xue , Fangfang Zhu , Changmiao Wang , Wenwen Min

For the past few years, deep generative models have increasingly been used in biological research for a variety of tasks. Recently, they have proven to be valuable for uncovering subtle cell phenotypic differences that are not directly…

Image and Video Processing · Electrical Eng. & Systems 2026-01-28 Anis Bourou , Thomas Boyer , Kévin Daupin , Véronique Dubreuil , Aurélie De Thonel , Valérie Mezger , Auguste Genovesio

In this paper I present some of the most representative biological models applied to robotics. In particular, this work represents a survey of some models inspired, or making use of concepts, by gene regulatory networks (GRNs): these…

Other Computer Science · Computer Science 2017-12-07 Michele Braccini

Inferring genetic networks from gene expression data is one of the most challenging work in the post-genomic era, partly due to the vast space of possible networks and the relatively small amount of data available. In this field, Gaussian…

Methodology · Statistics 2011-05-18 Marine Jeanmougin , Mickael Guedj , Christophe Ambroise

Gene regulatory networks (GRNs) are essential for understanding cell fate decisions and disease mechanisms, yet cross-species GRN inference from single-cell RNA-seq data remains challenging due to noise, sparsity, and cross-species…

Genomics · Quantitative Biology 2026-01-19 Shuai Yan , Qingzhi Yu , Wengfeng Dai , Xiang Cheng

Transcriptomic data is a treasure-trove in modern molecular biology, as it offers a comprehensive viewpoint into the intricate nuances of gene expression dynamics underlying biological systems. This genetic information must be utilised to…

Molecular Networks · Quantitative Biology 2023-12-13 Vikram Singh , Vikram Singh

Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

The widespread use of GPS devices has driven advances in spatiotemporal data mining, enabling machine learning models to simulate human decision making and generate realistic trajectories, addressing both data collection costs and privacy…

Machine Learning · Computer Science 2025-10-09 Zhiyang Zhang , Ningcong Chen , Xin Zhang , Yanhua Li , Shen Su , Hui Lu , Jun Luo

Gene regulatory networks are powerful tools for modeling interactions among genes to regulate their expression for homeostasis and differentiation. Single-cell sequencing offers a unique opportunity to build these networks with…

Molecular Networks · Quantitative Biology 2026-01-06 Yasin Uzun

We propose a randomized neural network approach called RaNNDy for learning transfer operators and their spectral decompositions from data. The weights of the hidden layers of the neural network are randomly selected and only the output…

Machine Learning · Computer Science 2025-09-25 Mohammad Tabish , Benedict Leimkuhler , Stefan Klus

Motivation :Reconstructing the topology of a gene regulatory network is one of the key tasks in systems biology. Despite of the wide variety of proposed methods, very little work has been dedicated to the assessment of their stability…

Molecular Networks · Quantitative Biology 2012-08-20 Marco Grimaldi , Giuseppe Jurman , Roberto Visintainer

One of the focus areas of modern scientific research is to reveal mysteries related to genes and their interactions. The dynamic interactions between genes can be encoded into a gene regulatory network (GRN), which can be used to gain…

Optimization and Control · Mathematics 2020-07-16 Atte Aalto , Lauri Viitasaari , Pauliina Ilmonen , Laurent Mombaerts , Jorge Goncalves

Correct inference of genetic regulations inside a cell is one of the greatest challenges in post genomic era for the biologist and researchers. Several intelligent techniques and models were already proposed to identify the regulatory…

Artificial Intelligence · Computer Science 2017-08-03 Sudip Mandal , Goutam Saha , Rajat K. Pal

This paper introduces a deep learning enabled generative sensing framework which integrates low-end sensors with computational intelligence to attain a high recognition accuracy on par with that attained with high-end sensors. The proposed…

Computer Vision and Pattern Recognition · Computer Science 2018-01-10 Lina Karam , Tejas Borkar , Yu Cao , Junseok Chae

Genes are fundamental for analyzing biological systems and many recent works proposed to utilize gene expression for various biological tasks by deep learning models. Despite their promising performance, it is hard for deep neural networks…

Machine Learning · Computer Science 2023-04-12 Xinnan Dai , Caihua Shan , Jie Zheng , Xiaoxiao Li , Dongsheng Li

Understanding causal relationships within Gene Regulatory Networks (GRNs) is essential for unraveling the gene interactions in cellular processes. However, causal discovery in GRNs is a challenging problem for multiple reasons including the…

Artificial Intelligence · Computer Science 2023-10-06 Trang Nguyen , Alexander Tong , Kanika Madan , Yoshua Bengio , Dianbo Liu

Gene mining is an important topic in the field of life sciences, but traditional machine learning methods cannot consider the regulatory relationships between genes. Deep learning methods perform poorly in small sample sizes. This study…

Quantitative Methods · Quantitative Biology 2023-08-08 Kerui Huang , Jianhong Tian , Lei Sun , Li Zeng , Peng Xie , Aihua Deng , Ping Mo , Zhibo Zhou , Ming Jiang , Yun Wang , Xiaocheng Jiang

Graph Neural Networks (GNNs) have emerged as promising solutions for collaborative filtering (CF) through the modeling of user-item interaction graphs. The nucleus of existing GNN-based recommender systems involves recursive message passing…

Machine Learning · Computer Science 2024-05-21 Peiyan Zhang , Yuchen Yan , Xi Zhang , Chaozhuo Li , Senzhang Wang , Feiran Huang , Sunghun Kim

Predicting how genetic perturbations change cellular state is a core problem for building controllable models of gene regulation. Perturbations targeting the same gene can produce different transcriptional responses depending on their…

Genomics · Quantitative Biology 2026-02-12 Boyang Fu , George Dasoulas , Sameer Gabbita , Xiang Lin , Shanghua Gao , Xiaorui Su , Soumya Ghosh , Marinka Zitnik

Recent works show that the graph structure of sentences, generated from dependency parsers, has potential for improving event detection. However, they often only leverage the edges (dependencies) between words, and discard the dependency…

Computation and Language · Computer Science 2021-05-06 Sanghamitra Dutta , Liang Ma , Tanay Kumar Saha , Di Lu , Joel Tetreault , Alejandro Jaimes