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A novel mechanism for cell differentiation is proposed, based on the dynamic clustering in a globally coupled chaotic system. A simple model with metabolic reaction, active transport of chemicals from media, and cell division is found to…

adap-org · Physics 2009-10-22 Kunihiko Kaneko , Tetsuya Yomo

Motivated by recent experiments with confined binary liquid mixtures near demixing, we study the universal critical properties of a system, which belongs to the Ising universality class, in the film geometry. We employ periodic boundary…

Statistical Mechanics · Physics 2010-11-29 Francesco Parisen Toldin , Siegfried Dietrich

Phase separation driven by nonequilibrium fluctuations is a hallmark of both living and synthetic active matter. Unlike equilibrium systems, where ordered states arise from the minimization of free energy, active systems are fueled by a…

The motion of a eukaryotic cell presents a variety of interesting and challenging problems from both a modeling and a computational perspective. The processes span many spatial scales (from molecular to tissue) as well as disparate time…

Cell Behavior · Quantitative Biology 2010-11-25 Ben Vanderlei , James J. Feng , Leah Edelstein-Keshet

Within the framework of a discrete Gaussian model, we present analytical results for the interaction induced by a lamellar phase between small embedded colloids. We consider the two limits of particles strongly adherent to the adjacent…

Biological cells use droplets to separate components and spatially control their interior. Experiments demonstrate that the complex, crowded cellular environment affects the droplet arrangement and their sizes. To understand this behavior,…

Soft Condensed Matter · Physics 2021-10-27 Estefania Vidal-Henriquez , David Zwicker

Motivated by recent experiments with confined binary liquid mixtures near their continous demixing phase transition we study the critical behavior of a system, which belongs to the Ising universality class, for the film geometry with one…

Soft Condensed Matter · Physics 2017-08-23 F. Parisen Toldin , S. Dietrich

The Casimir effect in quantum electrodynamics (QED) is perhaps the best-known example of fluctuation-induced long-ranged force acting on objects (conducting plates) immersed in a fluctuating medium (quantum electromagnetic field in vacuum).…

Statistical Mechanics · Physics 2009-07-13 Andrea Gambassi

Lipid membranes regulate the flow of materials and information between cells and their organelles. Further, lipid composition and morphology can play a key role in regulating a variety of biological processes. For example, viral uptake,…

Biomolecules · Quantitative Biology 2009-05-12 Tristan Ursell , Rob Phillips

On the examples of the quantum-electrodynamical Casimir force, as well as critical Casimir and Helmholtz forces, we present a review of some results available for the class of fluctuation induced forces. In addition, we also concisely…

Statistical Mechanics · Physics 2024-06-17 Daniel Dantchev

The static Casimir effect describes an attractive force between two conducting plates, due to quantum fluctuations of the electromagnetic (EM) field in the intervening space. {\it Thermal fluctuations} of correlated fluids (such as critical…

Condensed Matter · Physics 2008-11-26 Mehran Kardar , Ramin Golestanian

Membrane organization is essential for cellular functions such as signal transduction and membrane trafficking. A major challenge is to understand the lateral heterogeneous structures in membranes and membrane fluidity in the presence of…

Soft Condensed Matter · Physics 2007-11-09 Chun-Lai Ren , Yu-qiang Ma

Demixing of multicomponent biomolecular systems via liquid-liquid phase separation (LLPS) has emerged as a potentially unifying mechanism governing the formation of several membrane-less intracellular organelles ("condensates"), both in the…

Soft Condensed Matter · Physics 2022-10-04 Pierre Ronceray , Sheng Mao , Andrej Košmrlj , Mikko P. Haataja

Spatiotemporal patterns in multicellular systems are important to understanding tissue dynamics, for instance, during embryonic development and disease. Here, we use a multiphase field model to study numerically the behavior of a…

Soft Condensed Matter · Physics 2025-02-13 Michael Chiang , Austin Hopkins , Benjamin Loewe , M. Cristina Marchetti , Davide Marenduzzo

Many fundamental biological processes are dependent on cellular migration. Although the mechanical mechanisms of single-cell migration are relatively well understood, those underlying migration of multiple cells adhered to each other in a…

Biological Physics · Physics 2023-07-25 Katsuhiko Sato

Limited-valency colloidal particles can self-assemble into polymeric structures analogous to molecules. While their structural equilibrium properties have attracted wide attention, insight into their dynamics has proven challenging. Here,…

Soft Condensed Matter · Physics 2021-09-08 Simon Stuij , Joep Rouwhorst , Hannah Jonas , Nicola Ruffino , Zhe Gong , Stefanno Sacanna , Peter Bolhuis , Peter Schall

Cell membranes interact with a myriad of curvature-active proteins that control membrane morphology and are responsible for mechanosensation and mechanotransduction. Some of these proteins, such as those containing BAR domains, are curved…

Soft Condensed Matter · Physics 2020-09-21 Caterina Tozzi , Nikhil Walani , Anabel-Lise Le Roux , Pere Roca-Cusachs , Marino Arroyo

We demonstrate how concepts of statistical mechanics of interacting particles can have important implications in the choice of interaction potentials to model qualitative properties of cell aggregates in theoretical biology. We illustrate…

Cell Behavior · Quantitative Biology 2017-06-29 J. A. Carrillo , A. Colombi , M. Scianna

Endocytosis is an essential process by which cells internalize a piece of plasma membrane and material from the outside. In cells with turgor, pressure opposes membrane defor- mations, and increases the amount of force that has to be…

Biological Physics · Physics 2016-02-17 Serge Dmitrieff , François Nédélec

Water molecules confined between biological membranes exhibit a distinctive non-Gaussian displacement distribution, far different from bulk water. Here, we introduce a new transport equation for water molecules in the intermembrane space,…

Soft Condensed Matter · Physics 2024-04-19 Minho Lee , Euihyun Lee , Ji-Hyun Kim , Hyonseok Hwang , Minhaeng Cho , Jaeyoung Sung