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Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the…

Genomics · Quantitative Biology 2015-04-09 Andrew L. Beam , Alison Motsinger-Reif , Jon Doyle

Functional brain imaging through electroencephalography (EEG) relies upon the analysis and interpretation of high-dimensional, spatially organized time series. We propose to represent time-localized frequency domain characterizations of EEG…

There is a broad need in the neuroscience community to understand and visualize large-scale recordings of neural activity, big data acquired by tens or hundreds of electrodes simultaneously recording dynamic brain activity over minutes to…

Neurons and Cognition · Quantitative Biology 2015-11-24 Bingni W. Brunton , Lise A. Johnson , Jeffrey G. Ojemann , J. Nathan Kutz

In image enhancement tasks, such as low-light and underwater image enhancement, a degraded image can correspond to multiple plausible target images due to dynamic photography conditions. This naturally results in a one-to-many mapping…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Guoxi Huang , Qirui Yang , Ruirui Lin , Zipeng Qi , David Bull , Nantheera Anantrasirichai

Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…

Applications · Statistics 2018-03-02 Ixavier A. Higgins , Suprateek Kundu , Ying Guo

In many complex, real-world situations, problem solving and decision making require effective reasoning about causation and uncertainty. However, human reasoning in these cases is prone to confusion and error. Bayesian networks (BNs) are an…

Brain foundation models (BFMs) have emerged as a transformative paradigm in computational neuroscience, offering a revolutionary framework for processing diverse neural signals across different brain-related tasks. These models leverage…

Machine Learning · Computer Science 2025-07-22 Xinliang Zhou , Chenyu Liu , Zhisheng Chen , Kun Wang , Yi Ding , Ziyu Jia , Qingsong Wen

Bayesian networks (BNs) are a widely used graphical model in machine learning for representing knowledge with uncertainty. The mainstream BN structure learning methods require performing a large number of conditional independence (CI)…

Machine Learning · Computer Science 2022-12-09 Jiantong Jiang , Zeyi Wen , Ajmal Mian

This paper addresses the scalability problem of Bayesian deep neural networks. The performance of deep neural networks is undermined by the fact that these algorithms have poorly calibrated measures of uncertainty. This restricts their…

Machine Learning · Computer Science 2021-04-20 Sam Maksoud , Kun Zhao , Can Peng , Brian C. Lovell

Recent advances in reconstruction methods for inverse problems leverage powerful data-driven models, e.g., deep neural networks. These techniques have demonstrated state-of-the-art performances for several imaging tasks, but they often do…

Computer Vision and Pattern Recognition · Computer Science 2020-10-20 Riccardo Barbano , Chen Zhang , Simon Arridge , Bangti Jin

Analysis of brain imaging scans is critical to understanding the way the human brain functions, which can be leveraged to treat injuries and conditions that affect the quality of life for a significant portion of the human population. In…

Methodology · Statistics 2022-03-02 Daniel Spencer , David Bolin , Mary Beth Nebel , Amanda Mejia

Blind deconvolution (BD) has been demonstrated as an efficacious approach for extracting bearing fault-specific features from vibration signals under strong background noise. Despite BD's desirable feature in adaptability and mathematical…

Signal Processing · Electrical Eng. & Systems 2024-04-25 Jing-Xiao Liao , Chao He , Jipu Li , Jinwei Sun , Shiping Zhang , Xiaoge Zhang

This study presents band-ensemble Spectral Proper Orthogonal Decomposition (bSPOD). The approach is inspired by frequency smoothing, a method used to reduce estimator variance in power spectral density estimates, and is here extended to…

Hyperspectral image analysis often requires selecting the most informative bands instead of processing the whole data without losing the key information. Existing band reduction (BR) methods have the capability to reveal the nonlinear…

Computer Vision and Pattern Recognition · Computer Science 2018-12-03 Muhammad Ahmad , Asad Khan , Adil Mehmood Khan , Rasheed Hussain

Image decomposition aims to analyze an image into elementary components, which is essential for numerous downstream tasks and also by nature provides certain interpretability to the analysis. Deep learning can be powerful for such tasks,…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Sihan Wang , Shangqi Gao , Fuping Wu , Xiahai Zhuang

Bayesian experimental design (BED) provides a principled framework for optimizing data collection by choosing experiments that are maximally informative about unknown parameters. However, existing methods cannot deal with the joint…

Machine Learning · Statistics 2026-01-30 Sara Pérez-Vieites , Sahel Iqbal , Simo Särkkä , Dominik Baumann

We propose a model of brain atrophy as a function of high-dimensional genetic information and low dimensional covariates such as gender, age, APOE gene, and disease status. A nonparametric single-index Bayesian model of high dimension is…

Methodology · Statistics 2019-11-11 Arkaprava Roy , Subhashis Ghosal , Kingshuk Roy Choudhury

We introduce a framework for Bayesian experimental design (BED) with implicit models, where the data-generating distribution is intractable but sampling from it is still possible. In order to find optimal experimental designs for such…

Machine Learning · Statistics 2021-05-11 Steven Kleinegesse , Michael U. Gutmann

Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

Recent advances in deep learning have had a methodological and practical impact on brain-computer interface research. Among the various deep network architectures, convolutional neural networks have been well suited for…

Signal Processing · Electrical Eng. & Systems 2020-03-06 Wonjun Ko , Eunjin Jeon , Seungwoo Jeong , Heung-Il Suk