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Designing protein sequences with specific biological functions and structural stability is crucial in biology and chemistry. Generative models already demonstrated their capabilities for reliable protein design. However, previous models are…

Machine Learning · Computer Science 2024-02-28 Lin Zongying , Li Hao , Lv Liuzhenghao , Lin Bin , Zhang Junwu , Chen Calvin Yu-Chian , Yuan Li , Tian Yonghong

Diffusion models have demonstrated remarkable performance in generating unimodal data across various tasks, including image, video, and text generation. On the contrary, the joint generation of multimodal data through diffusion models is…

Machine Learning · Computer Science 2025-06-16 Kevin Rojas , Yuchen Zhu , Sichen Zhu , Felix X. -F. Ye , Molei Tao

Anomaly detection aims to identify samples that deviate from the nominal data distribution and is central to many safety-critical applications. However, developing effective anomaly detection methods for categorical, mixed-type, and…

Machine Learning · Computer Science 2026-05-29 Lixing Zhang , Yuchen Liang , Liyan Xie

Data-driven deep learning models have enabled tremendous progress in change detection (CD) with the support of pixel-level annotations. However, collecting diverse data and manually annotating them is costly, laborious, and…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Qi Zang , Jiayi Yang , Shuang Wang , Dong Zhao , Wenjun Yi , Zhun Zhong

Tabular data generation considers a large table with multiple columns -- each column comprised of numerical, categorical, or sometimes ordinal values. The goal is to produce new rows for the table that replicate the distribution of rows…

Machine Learning · Computer Science 2026-05-19 Meysam Alishahi , Yan Zheng , Junpeng Wang , Chin-Chia Michael Yeh , Jeff M. Phillips

Diffusion models achieve great success in generating diverse and high-fidelity images, yet their widespread application, especially in real-time scenarios, is hampered by their inherently slow generation speed. The slow generation stems…

Computer Vision and Pattern Recognition · Computer Science 2024-08-19 Shengkun Tang , Yaqing Wang , Caiwen Ding , Yi Liang , Yao Li , Dongkuan Xu

Diffusion models have recently shown promise in time series forecasting, particularly for probabilistic predictions. However, they often fail to achieve state-of-the-art point estimation performance compared to regression-based methods.…

Artificial Intelligence · Computer Science 2025-11-25 Hang Ding , Xue Wang , Tian Zhou , Tao Yao

Diffusion-based tabular data synthesis models have yielded promising results. However, when the data dimensionality increases, existing models tend to degenerate and may perform even worse than simpler, non-diffusion-based models. This is…

Machine Learning · Computer Science 2025-11-12 Zuqing Li , Junhao Gan , Jianzhong Qi

In recent years, generative diffusion models have achieved a rapid paradigm shift in deep generative models by showing groundbreaking performance across various applications. Meanwhile, structured data, encompassing tabular and time series…

Machine Learning · Computer Science 2023-07-11 Heejoon Koo , To Eun Kim

Building Virtual Cells that can accurately simulate cellular responses to perturbations is a long-standing goal in systems biology. A fundamental challenge is that high-throughput single-cell sequencing is destructive: the same cell cannot…

Machine Learning · Computer Science 2026-02-24 Xinyu Yuan , Xixian Liu , Ya Shi Zhang , Zuobai Zhang , Hongyu Guo , Jian Tang

Generative models for tabular data have evolved rapidly beyond Generative Adversarial Networks (GANs). While GANs pioneered synthetic tabular data generation, recent advances in diffusion models and large language models (LLMs) have opened…

Machine Learning · Computer Science 2026-04-10 Insaf Ashrapov

Graph diffusion models have gained significant attention in graph generation tasks, but they often inherit and amplify topology biases from sensitive attributes (e.g. gender, age, region), leading to unfair synthetic graphs. Existing fair…

Machine Learning · Computer Science 2026-03-03 Wendi Wang , Jiaxi Yang , Yongkang Du , Lu Lin

Diffusion models have emerged as a promising approach for text generation, with recent works falling into two main categories: discrete and continuous diffusion models. Discrete diffusion models apply token corruption independently using…

Computation and Language · Computer Science 2025-05-29 Bocheng Li , Zhujin Gao , Linli Xu

Diffusion-based generative models have shown promise in synthesizing histopathology images to address data scarcity caused by privacy constraints. Diagnostic text reports provide high-level semantic descriptions, and masks offer…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Mahesh Bhosale , Abdul Wasi , Yuanhao Zhai , Yunjie Tian , Samuel Border , Nan Xi , Pinaki Sarder , Junsong Yuan , David Doermann , Xuan Gong

The paradigm shift toward structure-driven molecule generation has been propelled by advances in deep generative models, such as variational auto-encoders and diffusion models. However, these generative models for molecular design remain…

Machine Learning · Computer Science 2026-04-17 Peidong Liu , Wenbo Zhang , Wei Ju , Jiancheng Lv , Xianggen Liu

Tables are an abundant form of data with use cases across all scientific fields. Real-world datasets often contain anomalous samples that can negatively affect downstream analysis. In this work, we only assume access to contaminated data…

Machine Learning · Computer Science 2023-07-25 Guy Zamberg , Moshe Salhov , Ofir Lindenbaum , Amir Averbuch

Graph generation is a critical yet challenging task, as empirical analyses require a deep understanding of complex, non-Euclidean structures. Diffusion models have recently made significant advances in graph generation, but these models are…

Machine Learning · Computer Science 2026-03-13 Yiming Huang , Tolga Birdal

Transformers have shown impressive results in tabular data generation. However, they lack domain-specific inductive biases which are critical for preserving the intrinsic characteristics of tabular data. They also suffer from poor…

Machine Learning · Computer Science 2025-05-19 Jiayu Li , Bingyin Zhao , Zilong Zhao , Uzair Javaid , Kevin Yee , Biplab Sikdar

We present TimeAutoDiff, a unified latent-diffusion framework for four fundamental time-series tasks: unconditional generation, missing-data imputation, forecasting, and time-varying-metadata conditional generation. The model natively…

Machine Learning · Computer Science 2025-12-09 Namjoon Suh , Yuning Yang , Din-Yin Hsieh , Qitong Luan , Shirong Xu , Shixiang Zhu , Guang Cheng

Synthetic data generation is an important tool for privacy-preserving data sharing. Although diffusion models have set recent benchmarks, flow matching (FM) offers a promising alternative. This paper presents different ways to implement FM…

Machine Learning · Computer Science 2026-03-18 Bahrul Ilmi Nasution , Floor Eijkelboom , Mark Elliot , Richard Allmendinger , Christian A. Naesseth