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We present MeFEm, a vision model based on a modified Joint Embedding Predictive Architecture (JEPA) for biometric and medical analysis from facial images. Key modifications include an axial stripe masking strategy to focus learning on…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Yury Borets , Stepan Botman

Recent advancements in multimodal foundation models have yielded significant progress in vision-language understanding. Initial attempts have also explored the potential of multimodal large language models (MLLMs) for visual content…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Rongyao Fang , Chengqi Duan , Kun Wang , Hao Li , Hao Tian , Xingyu Zeng , Rui Zhao , Jifeng Dai , Hongsheng Li , Xihui Liu

Vision-language foundation models achieve promising performance in natural image classification, yet their direct application to medical imaging is limited by severe domain shifts, resolution mismatches, and the multi-label nature of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Yitong Li , Morteza Ghahremani , Christian Wachinger

Alzheimer's disease, a neurodegenerative disorder, is associated with neural, genetic, and proteomic factors while affecting multiple cognitive and behavioral faculties. Traditional AD prediction largely focuses on univariate disease…

Visualizing and interpreting convolutional neural networks (CNNs) is an important task to increase trust in automatic medical decision making systems. In this study, we train a 3D CNN to detect Alzheimer's disease based on structural MRI…

Computer Vision and Pattern Recognition · Computer Science 2018-12-07 Johannes Rieke , Fabian Eitel , Martin Weygandt , John-Dylan Haynes , Kerstin Ritter

Creating a meaningful representation by fusing single modalities (e.g., text, images, or audio) is the core concept of multimodal learning. Although several techniques for building multimodal representations have been proven successful,…

Machine Learning · Computer Science 2025-08-08 Maciej Pawłowski , Anna Wróblewska , Sylwia Sysko-Romańczuk

Recent studies show that deep learning models achieve good performance on medical imaging tasks such as diagnosis prediction. Among the models, multimodality has been an emerging trend, integrating different forms of data such as chest…

Machine Learning · Computer Science 2022-02-10 Haodi Zhang , Chenyu Xu , Peirou Liang , Ke Duan , Hao Ren , Weibin Cheng , Kaishun Wu

Designing a neural network architecture for molecular representation is crucial for AI-driven drug discovery and molecule design. In this work, we propose a new framework for molecular representation learning. Our contribution is threefold:…

Machine Learning · Computer Science 2022-10-18 Jiye Kim , Seungbeom Lee , Dongwoo Kim , Sungsoo Ahn , Jaesik Park

Inevitable domain and task discrepancies in real-world scenarios can impair the generalization performance of the pre-trained deep models for medical data. Therefore, we audaciously propose that we should build a general-purpose medical AI…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Huahui Yi , Ziyuan Qin , Qicheng Lao , Wei Xu , Zekun Jiang , Dequan Wang , Shaoting Zhang , Kang Li

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Understanding how chemical perturbations propagate through biological systems is essential for robust molecular property prediction. While most existing methods focus on chemical structures alone, recent advances highlight the crucial role…

Machine Learning · Computer Science 2025-11-27 Mengran Li , Zelin Zang , Wenbin Xing , Junzhou Chen , Ronghui Zhang , Jiebo Luo , Stan Z. Li

Due to its complexity, graph learning-based multi-modal integration and classification is one of the most challenging obstacles for disease prediction. To effectively offset the negative impact between modalities in the process of…

Machine Learning · Computer Science 2025-02-14 Jin Liu , Junbin Mao , Hanhe Lin , Hulin Kuang , Shirui Pan , Xusheng Wu , Shan Xie , Fei Liu , Yi Pan

The accurate screening of candidate drug ligands against target proteins through computational approaches is of prime interest to drug development efforts. Such virtual screening depends in part on methods to predict the binding affinity…

Machine Learning · Computer Science 2024-10-22 Ho-Joon Lee , Prashant S. Emani , Mark B. Gerstein

Multimodal fusion benefits disease diagnosis by providing a more comprehensive perspective. Developing algorithms is challenging due to data heterogeneity and the complex within- and between-modality associations. Deep-network-based…

Neurons and Cognition · Quantitative Biology 2020-06-18 Wenxing Hu , Xianghe Meng , Yuntong Bai , Aiying Zhang , Biao Cai , Gemeng Zhang , Tony W. Wilson , Julia M. Stephen , Vince D. Calhoun , Yu-Ping Wang

Multiple types or views of data (e.g. genetics, proteomics) measured on the same set of individuals are now popularly generated in many biomedical studies. A particular interest might be the detection of sample subgroups (e.g. subtypes of…

Methodology · Statistics 2025-05-09 Kaifeng Yang , Thierry Chekouo , Sandra E. Safo

Cardiac magnetic resonance imaging (CMR), considered the gold standard for noninvasive cardiac assessment, is a diverse and complex modality requiring a wide variety of image processing tasks for comprehensive assessment of cardiac…

Image and Video Processing · Electrical Eng. & Systems 2025-12-03 Athira J Jacob , Indraneel Borgohain , Teodora Chitiboi , Puneet Sharma , Dorin Comaniciu , Daniel Rueckert

Accurately predicting enzyme functionality remains one of the major challenges in computational biology, particularly for enzymes with limited structural annotations or sequence homology. We present a novel multimodal Quantum Machine…

Machine Learning · Computer Science 2025-08-21 Murat Isik , Mandeep Kaur Saggi , Humaira Gowher , Sabre Kais

Foundation models and vision-language pre-training have significantly advanced Vision-Language Models (VLMs), enabling multimodal processing of visual and linguistic data. However, their application in domain-specific agricultural tasks,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-23 Khang Nguyen Quoc , Phuong D. Dao , Luyl-Da Quach

Models that accurately predict properties based on chemical structure are valuable tools in drug discovery. However, for many properties, public and private training sets are typically small, and it is difficult for the models to generalize…

Quantitative Methods · Quantitative Biology 2022-11-08 Oscar Méndez-Lucio , Christos Nicolaou , Berton Earnshaw

MEG are non invasive neuroimaging techniques with excellent temporal and spatial resolution, crucial for studying brain function in dementia and Alzheimer Disease. They identify changes in brain activity at various Alzheimer stages,…

Machine Learning · Computer Science 2024-08-12 Alwani Liyana Ahmad , Jose Sanchez-Bornot , Roberto C. Sotero , Damien Coyle , Zamzuri Idris , Ibrahima Faye