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RNA inverse folding, designing sequences to form specific 3D structures, is critical for therapeutics, gene regulation, and synthetic biology. Current methods, focused on sequence recovery, struggle to address structural objectives like…

Machine Learning · Computer Science 2026-01-28 Qi Si , Xuyang Liu , Penglei Wang , Xin Guo , Yuan Qi , Yuan Cheng

Diffusion models have achieved state-of-the-art performance in generative modeling, yet their sampling procedures remain vulnerable to hallucinations-often stemming from inaccuracies in score approximation. In this work, we reinterpret…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Yiqi Tian , Pengfei Jin , Mingze Yuan , Na Li , Bo Zeng , Quanzheng Li

Sentiment classification (SC) often suffers from low-resource challenges such as domain-specific contexts, imbalanced label distributions, and few-shot scenarios. The potential of the diffusion language model (LM) for textual data…

Computation and Language · Computer Science 2024-09-24 Zhuowei Chen , Lianxi Wang , Yuben Wu , Xinfeng Liao , Yujia Tian , Junyang Zhong

Knowledge distillation (KD) is an effective model compression method that can transfer the internal capabilities of large language models (LLMs) to smaller ones. However, the multi-modal probability distribution predicted by teacher LLMs…

Computation and Language · Computer Science 2024-12-19 Tianyu Peng , Jiajun Zhang

To sample from a general target distribution $p_*\propto e^{-f_*}$ beyond the isoperimetric condition, Huang et al. (2023) proposed to perform sampling through reverse diffusion, giving rise to Diffusion-based Monte Carlo (DMC).…

Machine Learning · Statistics 2024-01-15 Xunpeng Huang , Difan Zou , Hanze Dong , Yian Ma , Tong Zhang

We present a supervised learning framework of training generative models for density estimation. Generative models, including generative adversarial networks, normalizing flows, variational auto-encoders, are usually considered as…

Machine Learning · Computer Science 2023-10-24 Yanfang Liu , Minglei Yang , Zezhong Zhang , Feng Bao , Yanzhao Cao , Guannan Zhang

Linear discriminant analysis is a widely used method for classification. However, the high dimensionality of predictors combined with small sample sizes often results in large classification errors. To address this challenge, it is crucial…

Machine Learning · Statistics 2025-01-09 Hongzhe Zhang , Arnab Auddy , Hongzhe Lee

Recent advances in diffusion models have demonstrated their strong capabilities in generating high-fidelity samples from complex distributions through an iterative refinement process. Despite the empirical success of diffusion models in…

Robotics · Computer Science 2024-07-03 Chaoyi Pan , Zeji Yi , Guanya Shi , Guannan Qu

In applications of diffusion models, controllable generation is of practical significance, but is also challenging. Current methods for controllable generation primarily focus on modifying the score function of diffusion models, while Mean…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Ao Li , Wei Fang , Hongbo Zhao , Le Lu , Ge Yang , Minfeng Xu

Long scan time significantly hinders the widespread applications of three-dimensional multi-contrast cardiac magnetic resonance (3D-MC-CMR) imaging. This study aims to accelerate 3D-MC-CMR acquisition by a novel method based on score-based…

Signal Processing · Electrical Eng. & Systems 2024-10-29 Yuanyuan Liu , Zhuo-Xu Cui , Shucong Qin , Congcong Liu , Hairong Zheng , Haifeng Wang , Yihang Zhou , Dong Liang , Yanjie Zhu

In this paper, we present an effective data augmentation framework leveraging the Large Language Model (LLM) and Diffusion Model (DM) to tackle the challenges inherent in data-scarce scenarios. Recently, DMs have opened up the possibility…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Kyuheon Jung , Yongdeuk Seo , Seongwoo Cho , Jaeyoung Kim , Hyun-seok Min , Sungchul Choi

Recent research has focused on designing neural samplers that amortize the process of sampling from unnormalized densities. However, despite significant advancements, they still fall short of the state-of-the-art MCMC approach, Parallel…

As Diffusion Models have shown promising performance, a lot of efforts have been made to improve the controllability of Diffusion Models. However, how to train Diffusion Models to have the disentangled latent spaces and how to naturally…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Wonwoong Cho , Hareesh Ravi , Midhun Harikumar , Vinh Khuc , Krishna Kumar Singh , Jingwan Lu , David I. Inouye , Ajinkya Kale

Understanding transition pathways between two meta-stable states of a molecular system is crucial to advance drug discovery and material design. However, unbiased molecular dynamics (MD) simulations are computationally infeasible because of…

Machine Learning · Computer Science 2025-01-28 Kiyoung Seong , Seonghyun Park , Seonghwan Kim , Woo Youn Kim , Sungsoo Ahn

We propose an unsupervised anomaly detection approach based on a physics-informed diffusion model for multivariate time series data. Over the past years, diffusion model has demonstrated its effectiveness in forecasting, imputation,…

Machine Learning · Computer Science 2025-08-18 Juhi Soni , Markus Lange-Hegermann , Stefan Windmann

Diffusion models have recently gained popularity for accelerated MRI reconstruction due to their high sample quality. They can effectively serve as rich data priors while incorporating the forward model flexibly at inference time, and they…

Image and Video Processing · Electrical Eng. & Systems 2023-10-20 Batu Ozturkler , Chao Liu , Benjamin Eckart , Morteza Mardani , Jiaming Song , Jan Kautz

Foundation models enable prompt-based classifiers for zero-shot and few-shot learning. Nonetheless, the conventional method of employing fixed prompts suffers from distributional shifts that negatively impact generalizability to unseen…

Machine Learning · Computer Science 2024-10-29 Yingjun Du , Gaowen Liu , Yuzhang Shang , Yuguang Yao , Ramana Kompella , Cees G. M. Snoek

Diffusion models are powerful tools for sampling from high-dimensional distributions by progressively transforming pure noise into structured data through a denoising process. When equipped with a guidance mechanism, these models can also…

Machine Learning · Computer Science 2026-05-04 Saeed Mohseni-Sehdeh , Walid Saad , Kei Sakaguchi , Tao Yu

Domain Generalization techniques aim to enhance model robustness by simulating novel data distributions during training, typically through various augmentation or stylization strategies. However, these methods frequently suffer from limited…

Computer Vision and Pattern Recognition · Computer Science 2024-12-20 Mehrdad Noori , Milad Cheraghalikhani , Ali Bahri , Gustavo Adolfo Vargas Hakim , David Osowiechi , Moslem Yazdanpanah , Ismail Ben Ayed , Christian Desrosiers

Diffusion-based image super-resolution (SR) methods have shown promise in reconstructing high-resolution images with fine details from low-resolution counterparts. However, these approaches typically require tens or even hundreds of…

Computer Vision and Pattern Recognition · Computer Science 2024-08-15 Xiao He , Huaao Tang , Zhijun Tu , Junchao Zhang , Kun Cheng , Hanting Chen , Yong Guo , Mingrui Zhu , Nannan Wang , Xinbo Gao , Jie Hu
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