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Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at sub-micron…

Optics · Physics 2021-04-08 Yi Zhang , Haonan Zong , Cheng Zong , Yuying Tan , Meng Zhang , Yuewei Zhan , Ji-Xin Cheng

Mid-infrared photothermal microscopy is a highly promising imaging technique that enables spatially resolved vibrational fingerprinting. The combination of infrared induced heating with optical readout at visible wavelengths provides…

Optics · Physics 2025-08-05 Dennis van de Lockand , Daan Wolters , Matz Liebel

Optical photothermal microscopy is a powerful, emerging method that overcomes the diffraction limit in infrared hyperspectral imaging by utilizing a visible probe laser beam to detect local temperature-induced modulation at the visible…

Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an…

Spectral imaging and detection of mid-infrared (mid-IR) wavelengths are emerging as an enabling technology of great technical and scientific interest; primarily because important chemical compounds display unique and strong mid-IR spectral…

Atomic Force Microscopy - Infrared (AFM-IR) has emerged as a useful technique for measuring absorption spectra with spatial resolution better than the optical diffraction limit. The technique relies on the movement of a probe for atomic…

Applied Physics · Physics 2024-01-17 Luca Quaroni

Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in a specimen. The performance, however, is limited in terms of spatial resolution and imaging speed. Here, instead of measuring the loss of the IR beam,…

Optics · Physics 2018-11-20 Yeran Bai , Delong Zhang , Lu Lan , Yimin Huang , Kerry Maize , Ali Shakouri , Ji-Xin Cheng

We present a system for molecular spectroscopy using a broadband mid-infrared laser with near infrared detection. Difference frequency generation of a Yb:fiber femtosecond laser produced a mid-infrared (MIR) source tunable from 2100-3700…

Optics · Physics 2015-05-30 Todd A. Johnson , Scott A. Diddams

Three-dimensional molecular imaging of living cells is essential for unraveling cellular metabolism and response to therapies. However, existing volumetric methods, including fluorescence microscopy and quantitative phase imaging, either…

Mid-infrared (MIR) spectroscopy is widely recognized as a powerful, non-distractive method for chemical analysis. However, its utility is constrained by a micrometer-scale spatial resolution imposed by the long-wavelength MIR diffraction…

Spectral imaging in the mid-infrared (MIR) range provides simultaneous morphological and chemical information of a wide variety of samples. However, current MIR technologies struggle to produce high-definition images over a broad spectral…

Sensitive mid-infrared (MIR) spectroscopy plays an indispensable role in various photon-starved conditions. However, the detection sensitivity of conventional MIR spectrometers is severely limited by excessive noises of the involved…

The progress of semiconductor electronics toward ever-smaller length scales and associated higher power densities brings a need for new high-resolution thermal microscopy techniques. Traditional thermal microscopy is performed by detecting…

Materials Science · Physics 2015-05-13 Todd Brintlinger , Yi Qi , Kamal H. Baloch , David Goldhaber-Gordon , John Cumings

Ovarian cancer detection has traditionally relied on a multi-step process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from several…

Multispectral mid-infrared (2-5 ${{\mu}m}$) imaging is a critical capability across science and technology, offering a window into the vibrational and thermal landscape of matter that is inaccessible to visible sensors. It bridges the…

Optics · Physics 2026-01-29 Daniel Beitner , Ziv Abelson , Eyal Hollander , Omri Meron , Haim Suchowski

Photothermal microscopy has recently complemented single molecule fluorescence microscopy by the detection of individual nano-objects in absorption. Photothermal techniques gain their superior sensitivity by exploiting a heat induced…

Optics · Physics 2015-05-28 Markus Selmke , Marco Braun , Frank Cichos

The capture of transient optical waveforms is critical to reveal dynamical phenomena in various fields. However, fast and sensitive mid-infrared (MIR) measurements are typically limited by processing bandwidth and detection sensitivity of…

Optics · Physics 2026-05-26 Wen Zhang , Kun Huang , Xu Wang , Ben Sun , Jianan Fang , Yijing Li , Heping Zeng

Mid-infrared (mid-IR) spectroscopy is a crucial workhorse for a plethora of analytical applications and is suitable for diverse materials, including gases, polymers or biological tissue. However, this technologically significant wavelength…

Optics · Physics 2022-02-23 Paul Kaufmann , Helen M. Chrzanowski , Aron Vanselow , Sven Ramelow

High-speed mid-infrared (MIR) videography constitutes an enabling tool to monitor and analyze various dynamics in scientific research and industrial applications, such as combustion diagnostics, explosion reactions, photosynthetic tracking,…

Optics · Physics 2026-05-28 Ruiyang Qin , Kun Huang , Min Peng , Jianan Fang , Ben Sun , Zhengru Guo , Heping Zeng

Room temperature detection of molecular vibrations in the mid-infrared (MIR, $\lambda$ =3-30$\mu$m) has numerous applications including real-time gas sensing, chemical reactivity, medical imaging, astronomical surveys, and quantum…

Applied Physics · Physics 2022-05-17 Rohit Chikkaraddy , Rakesh Arul , Lukas A. Jakob , Jeremy J. Baumberg
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